The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Surface Characteristics, Copper Release, and Toxicity of Nano‐ and Micrometer‐Sized Copper and Copper(II) Oxide Particles: A Cross‐Disciplinary Study
Abstract
An interdisciplinary and multianalytical research effort is undertaken to assess the toxic aspects of thoroughly characterized nano‐ and micrometer‐sized particles of oxidized metallic copper and copper(II) oxide in contact with cultivated lung cells, as well as copper release in relevant media. All particles, except micrometer‐sized Cu, release more copper in serum‐containing cell medium (supplemented Dulbecco's minimal essential medium) compared to identical exposures in phosphate‐buffered saline. Sonication of particles for dispersion prior to exposure has a large effect on the initial copper release from Cu nanoparticles. A clear size‐dependent effect is observed from both a copper release and a toxicity perspective. In agreement with greater released amounts of copper per quantity of particles from the nanometer‐sized particles compared to the micrometer‐sized particles, the nanometer particles cause a higher degree of DNA damage (single‐strand breaks) and cause a significantly higher percentage of cell death compared to cytotoxicity induced by micrometer‐sized particles. Cytotoxic effects related to the released copper fraction are found to be significantly lower than the effects related to particles. No DNA damage is induced by the released copper fraction.
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Cites
Limbach, L. K., Li, Y., Grass, R. N., Brunner, T. J., Hintermann, M. A., Muller, M., Gunther, D., & Stark, W. J. (2005) · Environmental Science & Technology · doi:10.1021/es051043o · Cited by 779
Cited by
The Toxic Effects and Mechanisms of CuO and ZnO Nanoparticles
Chang, Y.-N., Zhang, M., Xia, L., Zhang, J., & Xing, G. (2012) · Materials · doi:10.3390/ma5122850 · Cited by 772
Lee, J., Mahendra, S., & Alvarez, P. J. J. (2010) · ACS Nano · doi:10.1021/nn100866w · Cited by 750
Toxicity assessment of nanomaterials: methods and challenges
Dhawan, A., & Sharma, V. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3996-x · Cited by 466
Antimicrobial applications of copper
Vincent, M., Hartemann, P., & Engels-Deutsch, M. (2016) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2016.06.003 · Cited by 384
Semisch, A., Ohle, J., Witt, B., & Hartwig, A. (2014) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-11-10 · Cited by 203
Metadata
- Authors
- Midander, K., Cronholm, P., Karlsson, H. L., Elihn, K., Möller, L., Leygraf, C., & Wallinder, I. O.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2009-01-29
- Volume
- 5
- Issue
- 3
- Pages
- 389-399
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2046011229
- Cited by
- 431
- References
- 1
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Midander, K., Cronholm, P., Karlsson, H. L., Elihn, K., Möller, L., Leygraf, C., & Wallinder, I. O. (2009). Surface Characteristics, Copper Release, and Toxicity of Nano‐ and Micrometer‐Sized Copper and Copper(II) Oxide Particles: A Cross‐Disciplinary Study. Small. https://doi.org/10.1002/smll.200801220
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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