The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Surface Functionalization of Single Superparamagnetic Iron Oxide Nanoparticles for Targeted Magnetic Resonance Imaging
Open accessAbstract
Magnetic resonance imaging (MRI), a non‐invasive, non‐radiative technique, is thought to lead to cellular or even molecular resolution if optimized targeted MR contrast agents are introduced. This would allow diagnosing progressive diseases in early stages. Here, it is shown that the high binding affinity of poly(ethylene glycol)‐gallol (PEG‐gallol) allows freeze drying and re‐dispersion of 9 ± 2‐nm iron oxide cores individually stabilized with ≈9‐nm‐thick stealth coatings, yielding particle stability for at least 20 months. Particle size, stability, and magnetic properties of PEGylated particles are compared to Feridex, a commercially available untargeted negative MR contrast agent. Biotin‐PEG(3400)‐gallol/methoxy‐PEG(550)‐gallol stabilized nanoparticles are further functionalized with biotinylated human anti‐VCAM‐1 antibodies using the biotin–neutravidin linkage. Binding kinetics and excellent specificity of these nanoparticles are demonstrated using quartz crystal microbalance with dissipation monitoring (QCM‐D). These MR contrast agents can be functionalized with any biotinylated ligand at controlled ligand surface density, rendering them a versatile research tool.
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Cites
Adsorption of Gases in Multimolecular Layers
Brunauer, S., Emmett, P. H., & Teller, E. (1938) · Journal of the American Chemical Society · doi:10.1021/ja01269a023 · Cited by 28,156
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
Wang, Y.-X. J., Hussain, S. M., & Krestin, G. P. (2001) · European Radiology · doi:10.1007/s003300100908 · Cited by 1,381
Cited by
Biological applications of magnetic nanoparticles
Colombo, M., Carregal-Romero, S., Casula, M. F., Gutiérrez, L., Morales, M. P., Böhm, I. B., Heverhagen, J. T., Prosperi, D., & Parak, W. J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15337h · Cited by 1,315
Bioinspired catecholic chemistry for surface modification
Ye, Q., Zhou, F., & Liu, W. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15026j · Cited by 1,177
Biomimetic nanoparticles for inflammation targeting
Jin, K., Luo, Z., Zhang, B., & Pang, Z. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2017.12.002 · Cited by 359
Biodegradation of Iron Oxide Nanocubes: High-Resolution In Situ Monitoring
Lartigue, L., Alloyeau, D., Kolosnjaj-Tabi, J., Javed, Y., Guardia, P., Riedinger, A., Péchoux, C., Pellegrino, T., Wilhelm, C., & Gazeau, F. (2013) · ACS Nano · doi:10.1021/nn305719y · Cited by 274
Yang, H. Y., Li, Y., & Lee, D. S. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800011 · Cited by 107
Metadata
- Authors
- Amstad, E., Zurcher, S., Mashaghi, A., Wong, J. Y., Textor, M., & Reimhult, E.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2009-06-02
- Volume
- 5
- Issue
- 11
- Pages
- 1334-1342
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2095993498
- Cited by
- 224
- References
- 3
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- green
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