Cited by 107Nanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesNanoplatforms for cancer theranostics

Multifunctional and Stimuli‐Responsive Magnetic Nanoparticle‐Based Delivery Systems for Biomedical Applications

Yang, Hong Yu, Li, Yi, Lee, Doo Sung·2018·Advanced Therapeutics

Abstract

The design and development of a multifunctional and stimuli‐responsive magnetic nanoparticle (MNP)‐based drug delivery system has attracted great interest for the diagnosis and therapy of cancer. However, the effective incorporation of magnetic iron oxide nanoparticles into biomedical systems requires in vitro and in vivo stability, good biocompatibility, high loading efficacy, and controlled drug release. Surface‐functionalized magnetic iron oxide nanoparticles created using engineered surface ligands have presented new strategies for the applications of MNP‐based drug delivery systems in cancer imaging and therapy to overcome these obstacles. Moreover, the development and design of stimuli‐responsive ligands has been combined with the engineering of multiple physicochemical features into MNPs to enhance the performance of the MNP‐based delivery system. This review briefly overviews the latest developments in the design of multifunctional and stimuli‐responsive MNP‐based drug delivery systems and summarizes their applications in the diagnostic imaging and treatment of cancer.

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Crossref · 10.1002/adtp.201800011

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  • The target location can be easily reached by magnetic nanoparticles (MNPs), which are tiny and have a large specific surface area.

    “The target location can be easily reached by magnetic nanoparticles (MNPs), which are tiny and have a large specific surface area.185”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [185]

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Authors
Yang, H. Y., Li, Y., & Lee, D. S.
Affiliations
  • Jilin University of Chemical Technology (CN)
  • Sungkyunkwan University (KR)
Corresponding author
Lee, Doo Sung
Venue
Advanced Therapeutics
Publisher
Wiley
Published
2018-05-16
Volume
1
Issue
2
ISSN
2366-3987 (ISSN-L)
OpenAlex
W2804892728
Cited by
107
References
185
Citations by year
2026: 4 · 2025: 14 · 2024: 9 · 2023: 10 · 2022: 17 · 2021: 15 · 2020: 19 · 2019: 13 · 2018: 6
FWCI
4.29
Type
journal article
Language
en
Open access
closed
Locations
Advanced Therapeutics (publishedVersion)
Funders
  • National Research Foundation of Korea (NRF‐2017R1A5A1070259, NRF‐2017R1D1A1B03033988)
  • Ministry of Education, Science and Technology
  • Ministry of Science, ICT and Future Planning
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
magnetic nanoparticles, iron oxide nanoparticles, stimuli-responsive drug delivery, multifunctional drug delivery systems, cancer theranostics, tumor imaging, surface functionalization, controlled drug release, biocompatibility, magnetic hyperthermia

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