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Towards Designer Microparticles: Simultaneous Control of Anisotropy, Shape, and Size
Open accessAbstract
Biodegradable, compositionally anisotropic microparticles with two distinct compartments that exhibit controlled shapes and sizes are fabricated. These multifunctional particles are prepared by electrohydrodynamic co‐jetting of poly(lactide‐co‐glycolide) polymer solutions. By varying different solution and process parameters, namely, concentration and flow rate, a variety of non‐equilibrium bicompartmental shapes, such as discoid and rod‐shaped microparticles are produced in high yields. Optimization of jetting parameters, combined with filtration, results in near‐perfect, bicompartmental spherical particles in the size range of 3–5 µm. Simultaneous control over anisotropy, size, shape, and surface structure provides an opportunity to create truly multifunctional microparticles for a variety of biological applications, such as drug delivery, diagnostic assays, and theranostics.
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Berkland, C., Pack, D. W., & Kim, K. (. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.01.018 · Cited by 114
Cited by
Janus Particles: Synthesis, Self-Assembly, Physical Properties, and Applications
Walther, A., & Müller, A. H. E. (2013) · Chemical Reviews · doi:10.1021/cr300089t · Cited by 1,769
Brown, T. D., Habibi, N., Wu, D., Lahann, J., & Mitragotri, S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00743 · Cited by 182
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Metadata
- Authors
- Bhaskar, S., Pollock, K. M., Yoshida, M., & Lahann, J.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2010-01-27
- Volume
- 6
- Issue
- 3
- Pages
- 404-411
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2169365855
- Cited by
- 162
- References
- 1
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Bhaskar, S., Pollock, K. M., Yoshida, M., & Lahann, J. (2010). Towards Designer Microparticles: Simultaneous Control of Anisotropy, Shape, and Size. Small. https://doi.org/10.1002/smll.200901306
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