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Cited by 114Electrohydrodynamics and Fluid DynamicsElectrospun Nanofibers in Biomedical ApplicationsAerosol Filtration and Electrostatic Precipitation

Controlling surface nano-structure using flow-limited field-injection electrostatic spraying (FFESS) of poly(d,l-lactide-co-glycolide)

Berkland, Cory, Pack, Daniel W., Kim, Kyekyoon (Kevin)·2004·Biomaterials
DOI 10.1016/j.biomaterials.2004.01.018
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Abstract

Improved control of surface micro- and nano-structure may lead to enhanced performance of degradable biomedical devices such as surgical dressings, vascular grafts, tissue engineering scaffolds, sutures, and structures for guided tissue regeneration. An electrohydrodynamic method called flow-limited field-injection electrostatic spraying (FFESS) has been developed as an improved technique for the controlled deposition of polymeric material. Injecting charge using a nano-sharpened tungsten needle in a process called field ionization can efficiently induce an ionic state in a solution of poly(D,L-lactide-co-glycolide) increasing its capacity to carry charge. As a result, sprays have been produced that are finer and more precisely controlled than sprays produced by conventional electrospraying techniques, which employ hypodermic needles as the spray nozzle. Here, the effect of FFESS variables including applied voltage, polymer solution flow rate, and solvent properties (surface tension, viscosity, vapor pressure) on spray performance have been qualitatively evaluated. Under certain conditions, increasing the applied voltage produced an increasingly rough surface morphology. Similarly, by reducing solvent surface tension and increasing solvent vapor pressure, more distinct surface structures could be formed including uniform nanoparticles. Working ranges of the important parameters for the production of specific structure types such as smooth or porous surfaces, non-woven or melded fibers, and distinct or melded nanoparticles have been defined. FFESS technology provides a simple yet powerful technique for fabricating biomedical devices with a precisely defined nano-structure potentially capable of utilizing a broad range of biocompatible polymeric materials.

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  • Several new methods for manufacturing PLGA or PLA particles have been reported, including ultrasonic atomization, electrospray, microfluidic, pore-closing/thermoreversible-gel, and microfabrication.

    “Recently, several new methods to manufacture PLGA or PLA particles have been reported, such as the ultrasonic atomization method [14,15], the electrospray method [16], the microfluidic method [17,18], the pore-closing and thermoreversible-gel method [19,20], and the microfabrication method [21].”

    From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [16]

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Authors
Berkland, C., Pack, D. W., & Kim, K. (.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Kim, Kyekyoon (Kevin)
ORCID
Venue
Biomaterials
Publisher
Elsevier BV
Published
2004-11
Volume
25
Issue
25
Pages
5649-5658
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2004.01.018
OpenAlex
W2034161470
Cited by
114
References
44
Citations by year
2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 3
FWCI
10.08
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrohydrodynamics and Fluid Dynamics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Aerosol Filtration and Electrostatic Precipitation
Keywords
poly(lactic-co-glycolic acid), electrospraying, field ionization, surface morphology control, biodegradable polymers, biomedical devices, nanoparticles, solvent vapor pressure, applied voltage
MeSH terms
Polylactic Acid-Polyglycolic Acid Copolymer, Biocompatible Materials, Electricity, Microscopy, Electron, Scanning, Polyglycolic Acid, Polymers, Rheology, Solvents, Surface Properties, Surface Tension, Viscosity, Lactic Acid, Nanotechnology, Nanostructures

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