The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs
Abstract
A simple synthetic route for the preparation of functional nanoscale graphene oxide (NGO), a novel nanocarrier for the loading and targeted delivery of anticancer drugs, is reported. The NGO is functionalized with sulfonic acid groups, which render it stable in physiological solution, followed by covalent binding of folic acid (FA) molecules to the NGO, thus allowing it to specifically target MCF‐7 cells, human breast cancer cells with FA receptors. Furthermore, controlled loading of two anticancer drugs, doxorubicin (DOX) and camptothecin (CPT), onto the FA‐conjugated NGO (FA–NGO) via π–π stacking and hydrophobic interactions is investigated. It is demonstrated that FA–NGO loaded with the two anticancer drugs shows specific targeting to MCF‐7 cells, and remarkably high cytotoxicity compared to NGO loaded with either DOX or CPT only. Considering that the combined use of two or more drugs, a widely adopted clinical practice, often displays much better therapeutic efficacy than that of a single drug, the controlled loading and targeted delivery of mixed anticancer drugs using these graphene‐based nanocarriers may find widespread application in biomedicine.
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Cites
Geim, A. K., & Novoselov, K. S. (2007) · Nature Materials · doi:10.1038/nmat1849 · Cited by 39,979
The electronic properties of graphene
Castro Neto, A. H., Guinea, F., Peres, N. M. R., Novoselov, K. S., & Geim, A. K. (2009) · Reviews of Modern Physics · doi:10.1103/revmodphys.81.109 · Cited by 24,803
Graphene-based composite materials
Stankovich, S., Dikin, D. A., Dommett, G. H. B., Kohlhaas, K. M., Zimney, E. J., Stach, E. A., Piner, R. D., Nguyen, S. T., & Ruoff, R. S. (2006) · Nature · doi:10.1038/nature04969 · Cited by 12,922
Yokoyama, M. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00115-6 · Cited by 308
Cited by
Georgakilas, V., Perman, J. A., Tucek, J., & Zboril, R. (2015) · Chemical Reviews · doi:10.1021/cr500304f · Cited by 2,147
A Review on Nanofluids: Preparation, Stability Mechanisms, and Applications
Yu, W., & Xie, H. (2012) · Journal of Nanomaterials · doi:10.1155/2012/435873 · Cited by 1,770
Graphene-based nanomaterials for drug delivery and tissue engineering
Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
Nanotoxicity of Graphene and Graphene Oxide
Seabra, A. B., Paula, A. J., de Lima, R., Alves, O. L., & Durán, N. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400385x · Cited by 893
New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide
Feng, L., Wu, L., & Qu, X. (2013) · Advanced Materials · doi:10.1002/adma.201203229 · Cited by 632
Metadata
- Authors
- Zhang, L., Xia, J., Zhao, Q., Liu, L., & Zhang, Z.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2010-02-22
- Volume
- 6
- Issue
- 4
- Pages
- 537-544
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W1976787731
- Cited by
- 1,677
- References
- 4
- FWCI
- 32.61
- Type
- journal article
- Language
- en
- Open access
- closed
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