The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Nitric Oxide Donors for Cardiovascular Implant Applications
Abstract
In an era of increased cardiovascular disease burden in the ageing population, there is great demand for devices that come in to contact with the blood such as heart valves, stents, and bypass grafts that offer life saving treatments. Nitric oxide (NO) elution from healthy endothelial tissue that lines the vessels maintains haemostasis throughout the vasculature. Surgical devices that release NO are desirable treatment options and N ‐diazeniumdiolates and S ‐nitrosothiols are recognized as preferred donor molecules. There is a keen interest to investigate newer methods by which NO donors can be retained within biomaterials so that their release and kinetic profiles can be optimized. A range of polymeric scaffolds incorporating microparticles and nanomaterials are presenting solutions to current challenges, and have been investigated in a range of clinical applications. This review outlines the application of NO donors for cardiovascular therapy using biomaterials that release NO locally to prevent thrombosis and intimal hyperplasia (IH) and enhance endothelialization in the fabrication of next generation cardiovascular device technology.
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“The incorporation of these blood-contacting materials is usually complicated by foreign body responses that is initiated by the coagulation cascade1”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [1]
In the citing paper
“Reduced NO levels are associated with many health complications and/or diseases, such as high blood pressure, deep vein thrombosis, intimal hypertension, restenosis, endothelial dysfunction, and prolonged wound healing times in diabetic patients, etc.1,131,132”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [1]
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Self-citationRetractedGold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity
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Monolayer-Protected Cluster Molecules
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Mechanisms of Thrombus Formation
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Nanosilver as a new generation of nanoproduct in biomedical applications
Chaloupka, K., Malam, Y., & Seifalian, A. M. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.07.006 · Cited by 1,452
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Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer
Malam, Y., Loizidou, M., & Seifalian, A. M. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.08.004 · Cited by 1,317
Self-citationKim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912273 · Cited by 1,153
Introduction to metallic nanoparticles
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Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications
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Stimuli‐Responsive NO Release for On‐Demand Gas‐Sensitized Synergistic Cancer Therapy
Fan, W., Yung, B. C., & Chen, X. S. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201800594 · Cited by 368
The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials
Ploetz, E., Engelke, H., Lächelt, U., & Wuttke, S. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909062 · Cited by 355
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Yang, T., Zelikin, A. N., & Chandrawati, R. (2018) · Advanced Science · doi:10.1002/advs.201701043 · Cited by 311
Blood compatible materials: state of the art
Liu, X., Yuan, L., Li, D., Tang, Z., Wang, Y., Chen, G., Chen, H., & Brash, J. L. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb00881b · Cited by 292
Metadata
- Authors
- Naghavi, N., de Mel, A., Alavijeh, O. S., Cousins, B. G., & Seifalian, A. M.
- Affiliations
- University College London (GB)
- Royal Free London NHS Foundation Trust (GB)
- Corresponding author
- Seifalian, Alexander M.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2012-11-08
- Volume
- 9
- Issue
- 1
- Pages
- 22-35
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2025725319
- Cited by
- 188
- References
- 120
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 12 · 2023: 14 · 2022: 18 · 2021: 14 · 2020: 19 · 2019: 16 · 2018: 20 · 2017: 11 · 2016: 11 · 2015: 13 · 2014: 10 · 2013: 7
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- nitric oxide donors, cardiovascular implants, N-diazeniumdiolates, S-nitrosothiols, biomaterials, polymer scaffolds, microparticles, nanomaterials, thromboprophylaxis, intimal hyperplasia, endothelialization, drug-eluting devices, heart valves, stents, bypass grafts, NO release kinetics
- MeSH terms
- Biocompatible Materials, Cardiology, Cardiovascular Diseases, Endothelium, Vascular, Gold, Humans, Kinetics, Nitric Oxide, Platinum, Polymers, Silicon Dioxide, Silver, Stents, Prostheses and Implants, Nitric Oxide Donors, Hydrogels, S-Nitrosothiols, Nanotechnology, Nanostructures, Metal Nanoparticles
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