Polymers incorporating nitric oxide releasing/generating substances for improved biocompatibility of blood-contacting medical devices
Abstract
The current state-of-the-art with respect to the preparation, characterization and biomedical applications of novel nitric oxide (NO) releasing or generating polymeric materials is reviewed. Such materials show exceptional promise as coatings to prepare a new generation of medical devices with superior biocompatiblity. Nitric oxide is a well-known inhibitor of platelet adhesion and activation, as well as a potent inhibitor of smooth muscle cell proliferation. Hence, polymers that release or generate NO locally at their surface exhibit greatly enhanced thromboresistivity and have the potential to reduce neointimal hyperplasia caused by device damage to blood vessel walls. In this review, the use of diazeniumdiolates and nitrosothiols as NO donors within a variety polymeric matrixes are summarized. Such species can either be doped as discrete NO donors within polymeric films, or covalently linked to polymer backbones and/or inorganic polymeric filler particles that are often employed to enhance the strength of biomedical polymers (e.g., fumed silica or titanium dioxide). In addition, very recent efforts to create catalytic polymers possessing immobilized Cu(II) sites capable of generating NO from endogenous oxidized forms of NO already present in blood and other physiological fluids (nitrite and nitrosothiols) are discussed. Preliminary literature data illustrating the efficacy of the various NO release/generating polymers as coatings for intravascular sensors, extracorporeal blood loop circuits, and arteriovenous grafts/shunts are reviewed.
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Three main strategies for increasing NO bioavailability are exercise/diet, drugs that alter enzymatic NO production, and modified polymeric materials that deliver NO exogenously.
“There are three main strategies for increasing NO bioavailability: 1) by participating in physical exercise and controlling certain dietary components (e.g., nitrate-rich diet);132,133 2) by administrating drugs that alter the enzymatic production of NO through nitric oxide synthases (NOSs) and increase the biosynthesis of NO endogenously;117 and 3) by using modified polymeric materials that can”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [109]
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Self-citation
- Authors
- Frost, M. C., Reynolds, M. M., & Meyerhoff, M. E.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Meyerhoff, Mark E.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 26
- Issue
- 14
- Pages
- 1685-1693
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2037640551
- Cited by
- 343
- References
- 69
- Citations by year
- 2026: 11 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 20 · 2019: 22 · 2018: 20 · 2017: 16 · 2016: 25 · 2015: 18 · 2014: 24 · 2013: 24 · 2012: 21
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- nitric oxide donors, blood-contacting devices, biocompatibility, thromboresistance, intimal hyperplasia, diazeniumdiolates, S-nitrosothiols, polymer coatings, covalent polymerization, fumed silica, titanium dioxide, nitrite, extracorporeal circuit, arteriovenous graft
- MeSH terms
- Animals, Biocompatible Materials, Blood, Delayed-Action Preparations, Equipment and Supplies, Humans, Nitric Oxide, Platelet Adhesiveness, Polymers, Thrombosis
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