The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Understanding the Antibacterial Mechanism of CuO Nanoparticles: Revealing the Route of Induced Oxidative Stress
Abstract
To date, there is still a lack of definite knowledge regarding the interaction of CuO nanoparticles with bacteria and the possible permeation of the nanoparticles into bacterial cells. This study was aimed at shedding light on the size‐dependent (from the microscale down to the small nanoscale) antibacterial activity of CuO. The potent antibacterial activity of CuO nanoparticles was found to be due to ROS‐generation by the nanoparticles attached to the bacterial cells, which in turn provoked an enhancement of the intracellular oxidative stress. This paradigm was confirmed by several assays such as lipid peroxidation and reporter strains of oxidative stress. Furthermore, electron microscopy indicated that the small nanoparticles of CuO penetrated the cells. Collectively, the results reported herein may reconcile conflicting concepts in the literature concerning the antibacterial mechanism of CuO nanoparticles, as well as highlight the potential for developing sustainable CuO nanoparticles‐based devices for inhibiting bacterial infections.
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Cites
Chemistry and Properties of Nanocrystals of Different Shapes
Burda, C., Chen, X., Narayanan, R., & El-Sayed, M. A. (2005) · Chemical Reviews · doi:10.1021/cr030063a · Cited by 7,230
Oops they did it again! Carbon nanotubes hoax scientists in viability assays
Wörle-Knirsch, J. M., Pulskamp, K., & Krug, H. F. (2006) · Nano Letters · doi:10.1021/nl060177c · Cited by 994
Liu, G. Y., Essex, A., Buchanan, J. T., Datta, V., Hoffman, H. M., Bastian, J. F., Fierer, J., & Nizet, V. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050846 · Cited by 752
Cited by
Antimicrobial activity of metals: mechanisms, molecular targets and applications
Lemire, J. A., Harrison, J. J., & Turner, R. J. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3028 · Cited by 2,746
Pure and multi metal oxide nanoparticles: synthesis, antibacterial and cytotoxic properties
Stankic, S., Suman, S., Haque, F., & Vidic, J. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0225-6 · Cited by 678
Cai, L., Chen, J., Liu, Z., Wang, H., Yang, H., & Ding, W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00790 · Cited by 365
Ivask, A., Juganson, K., Bondarenko, O., Mortimer, M., Aruoja, V., Kasemets, K., Blinova, I., Heinlaan, M., Slaveykova, V., & Kahru, A. (2014) · Nanotoxicology · doi:10.3109/17435390.2013.855831 · Cited by 332
Asadishad, B., Chahal, S., Akbari, A., Cianciarelli, V., Azodi, M., Ghoshal, S., & Tufenkji, N. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.7b05389 · Cited by 319
Metadata
- Authors
- Applerot, G., Lellouche, J., Lipovsky, A., Nitzan, Y., Lubart, R., Gedanken, A., & Banin, E.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2012-08-13
- Volume
- 8
- Issue
- 21
- Pages
- 3326-3337
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2041986564
- Cited by
- 598
- References
- 3
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Applerot, G., Lellouche, J., Lipovsky, A., Nitzan, Y., Lubart, R., Gedanken, A., & Banin, E. (2012). Understanding the Antibacterial Mechanism of CuO Nanoparticles: Revealing the Route of Induced Oxidative Stress. Small. https://doi.org/10.1002/smll.201200772
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