The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Blood‐Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging
Open accessAbstract
The blood‐brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to malignant gliomas. Here, a transactivator of transcription (TAT) peptide‐modified gold nanoparticle platform (TAT‐Au NP) with a 5 nm core size is demonstrated to be capable of crossing the BBB efficiently and delivering cargoes such as the anticancer drug doxorubicin (Dox) and Gd 3+ contrast agents to brain tumor tissues. Treatment of mice bearing intracranial glioma xenografts with pH‐sensitive Dox‐conjugated TAT‐Au NPs via a single intravenous administration leads to significant survival benefit when compared to the free Dox. Furthermore, it is demonstrated that TAT‐Au NPs are capable of delivering Gd 3+ chelates for enhanced brain tumor imaging with a prolonged retention time of Gd 3+ when compared to the free Gd 3+ chelates. Collectively, these results show promising applications of the TAT‐Au NPs for enhanced malignant brain tumor therapy and non‐invasive imaging.
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Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807
Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma
Jensen, S. A., Day, E. S., Ko, C. H., Hurley, L. A., Luciano, J. P., Kouri, F. M., Merkel, T. J., Luthi, A. J., Patel, P. C., Cutler, J. I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006839 · Cited by 592
Cited by
Crossing the blood-brain barrier with nanoparticles
Zhou, Y., Peng, Z., Seven, E. S., & Leblanc, R. M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.015 · Cited by 837
Nanoparticles in Daily Life: Applications, Toxicity and Regulations
Gupta, R., & Xie, H. (2018) · Journal of Environmental Pathology, Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.2018026009 · Cited by 553
Hersh, A. M., Alomari, S., & Tyler, B. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084153 · Cited by 478
Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier
S. Hersh, D., S. Wadajkar, A., B. Roberts, N., G. Perez, J., P. Connolly, N., Frenkel, V., A. Winkles, J., F. Woodworth, G., & J. Kim, A. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151221150733 · Cited by 387
Nanocarrier-based drug combination therapy for glioblastoma
Zhao, M., van Straten, D., Broekman, M. L. D., Préat, V., & Schiffelers, R. M. (2020) · Theranostics · doi:10.7150/thno.38147 · Cited by 373
Metadata
- Authors
- Cheng, Y., Dai, Q., Morshed, R. A., Fan, X., Wegscheid, M. L., Wainwright, D. A., Han, Y., Zhang, L., Auffinger, B., Tobias, A. L., Rincón, E., Thaci, B., Ahmed, A. U., Warnke, P. C., He, C., & Lesniak, M. S.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2014-08-08
- Volume
- 10
- Issue
- 24
- Pages
- 5137-5150
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2108294913
- Cited by
- 271
- References
- 2
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Cheng, Y., Dai, Q., Morshed, R. A., Fan, X., Wegscheid, M. L., Wainwright, D. A., Han, Y., Zhang, L., Auffinger, B., Tobias, A. L., Rincón, E., Thaci, B., Ahmed, A. U., Warnke, P. C., He, C., & Lesniak, M. S. (2014). Blood‐Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging. Small. https://doi.org/10.1002/smll.201400654
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
