The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8)
Abstract
Recent work in biomolecule‐metal–organic framework (MOF) composites has proven to be an effective strategy for the protection of proteins. However, for other biomacromolecules such as nucleic acids, the encapsulation into nano MOFs and the related characterizations are in their infancy. Herein, encapsulation of a complete gene‐set in zeolitic imidazolate framework‐8 (ZIF‐8) MOFs and cellular expression of the gene delivered by the nano MOF composites are reported. Using a green fluorescent protein (GFP) plasmid (plGFP) as a proof‐of‐concept genetic macromolecule, successful transfection of mammalian cancer cells with plGFP for up to 4 days is shown. Cell transfection assays and soft X‐ray cryo‐tomography (cryo‐SXT) demonstrate the feasibility of DNA@MOF biocomposites as intracellular gene delivery vehicles. Expression occurs over relatively prolonged time points where the cargo nucleic acid is released gradually in order to maintain sustained expression.
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Cites
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Cited by
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
mRNA-based therapeutics: powerful and versatile tools to combat diseases
Qin, S., Tang, X., Chen, Y., Chen, K., Fan, N., Xiao, W., Zheng, Q., Li, G., Teng, Y., Wu, M., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01007-w · Cited by 771
Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy
He, X., Jiang, Z., Akakuru, O. U., Li, J., & Wu, A. (2021) · Chemical Communications · doi:10.1039/d1cc04846e · Cited by 303
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy
Guo, L., Zhong, S., Liu, P., Guo, M., Ding, J., & Zhou, W. (2022) · Small · doi:10.1002/smll.202202604 · Cited by 103
Metadata
- Authors
- Poddar, A., Conesa, J. J., Liang, K., Dhakal, S., Reineck, P., Bryant, G., Pereiro, E., Ricco, R., Amenitsch, H., Doonan, C., Mulet, X., Doherty, C. M., Falcaro, P., & Shukla, R.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2019-07
- Volume
- 15
- Issue
- 36
- Pages
- e1902268-e1902268
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2954470761
- Cited by
- 158
- References
- 4
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Poddar, A., Conesa, J. J., Liang, K., Dhakal, S., Reineck, P., Bryant, G., Pereiro, E., Ricco, R., Amenitsch, H., Doonan, C., Mulet, X., Doherty, C. M., Falcaro, P., & Shukla, R. (2019). Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8). Small. https://doi.org/10.1002/smll.201902268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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