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Cited by 73

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Electrostatic Charge‐Mediated Apoptotic Vesicle Biodistribution Attenuates Sepsis by Switching Neutrophil NETosis to Apoptosis

Ou, Qianmin, Tan, Lingping, Shao, Yiting, Lei, Fangcao, Huang, Weiying, Yang, Ning, Qu, Yan, Cao, Zeyuan, Niu, Luhan, Liu, Yao, Kou, Xiaoxing, Shi, Songtao·2022·Small
DOI 10.1002/smll.202200306
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Abstract

Mesenchymal stem cell (MSC) therapy can attenuate organ damage and reduce mortality in sepsis; however, the detailed mechanism is not fully elucidated. In this study, it is shown that MSC‐derived apoptotic vesicles (apoVs) can ameliorate multiple organ dysfunction and improve survival in septic mice. Mechanistically, it is found that tail vein‐infused apoVs mainly accumulate in the bone marrow of septic mice via electrostatic charge interactions with positively charged neutrophil extracellular traps (NETs). Moreover, apoVs switch neutrophils NETosis to apoptosis via the apoV‐Fas ligand (FasL)‐activated Fas pathway. In summary, these findings uncover a previously unknown role of apoVs in sepsis treatment and an electrostatic charge‐directed target therapeutic mechanism, suggesting that cell death is associated with disease development and therapy.

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Metadata

Authors
Ou, Q., Tan, L., Shao, Y., Lei, F., Huang, W., Yang, N., Qu, Y., Cao, Z., Niu, L., Liu, Y., Kou, X., & Shi, S.
Venue
Small
Publisher
Wiley
Published
2022-04-15
Volume
18
Issue
20
ISSN
  • 1613-6810
  • 1613-6829
DOI
10.1002/smll.202200306
Cited by
73
References
1
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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