On-demand removable self-healing and pH-responsive europium-releasing adhesive dressing enables inflammatory microenvironment modulation and angiogenesis for diabetic wound healing
Abstract
Current diabetic wound treatments remain unsatisfactory due to the lack of a comprehensive strategy that can integrate strong applicability (tissue adhesiveness, shape adaptability, fast self-healability, and facile dressing change) with the initiation and smooth connection of the cascade wound healing processes. Herein, benefiting from the multifaceted bonding ability of tannic acid to metal ions and various polymers, a family of tannin-europium coordination complex crosslinked citrate-based mussel-inspired bioadhesives (TE-CMBAs) are specially developed for diabetic wound healing. TE-CMBAs can gel instantly (< 60 s), possess favorable shape-adaptability, considerable mechanical strengths, high elasticity, considerable wet tissue adhesiveness (≈40 kPa), favorable photothermal antimicrobial activity, excellent anti-oxidant activity, biocompatibility, and angiogenetic property. The reversible hydrogen bond crosslinking and sensitive metal-phenolic coordination also confers TE-CMBAs with self-healability, pH-responsive europium ion and TA releasing properties and on-demand removability upon mixing with borax solution, enabling convenient painless dressing change and the smooth connection of inflammatory microenvironment modulation, angiogenesis promotion, and effective extracellular matrix production leveraging the acidic pH condition of diabetic wounds. This adhesive dressing provides a comprehensive regenerative strategy for diabetic wound management and can be extended to ot…
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Fu and coworkers developed a series of tannin-europium coordination complexes (TECs) crosslinked with citrate-based mussel-inspired bioadhesives (TE-CMBAs); the incorporation of TEC improved the antioxidant and anti-inflammatory capabilities of the hydrogel adhesives; in vivo results show that TE-CMBA hydrogels were able to modulate the inflammatory microenvironment, promote angiogenesis, enhance
“Fu and coworkers developed a series of tannin–europium coordination complexes (TECs) crosslinked with citrate-based mussel-inspired bioadhesives (TE-CMBAs). The incorporation of TEC improved the antioxidant and anti-inflammatory capabilities of the hydrogel adhesives. In vivo results show that the TE-CMBA hydrogels were able to modulate the inflammatory microenvironment, promote angiogenesis,”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [111]
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Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
“In vivo results show that the TE-CMBA hydrogels were able to modulate the inflammatory microenvironment, promote angiogenesis, enhance the production of the extracellular matrix (ECM), and improve re-epithelialization, showing effectiveness in the treatment of diabetic wounds [111].”
Background
- Authors
- Fu, M., Zhao, Y., Wang, Y., Li, Y., Wu, M., Liu, Q., Hou, Z., Lu, Z., Wu, K., & Guo, J.
- Affiliations
- Third Affiliated Hospital of Southern Medical University (CN)
- Regenerative Medicine and Tissue Repair Material Research Center Huangpu Institute of Materials Guangzhou 510530 P. R. China
- Corresponding author
- Wu, Keke
- Guo, Jinshan
- Venue
- Small
- Publisher
- Wiley
- Published
- 2022-11
- Volume
- 19
- Issue
- 3
- Pages
- e2205489-e2205489
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W4307970939
- Cited by
- 107
- References
- 0
- Citations by year
- 2026: 12 · 2025: 41 · 2024: 32 · 2023: 22
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82272453, U21A2099, 82102545, 32201077)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- diabetic wound healing, wound dressings, self-healing adhesives, pH-responsive drug release, tannic acid, hydrogen bond crosslinking, antioxidant activity, angiogenesis, extracellular matrix synthesis
- MeSH terms
- Adhesives, Anti-Bacterial Agents, Bandages, Diabetes Mellitus, Europium, Humans, Hydrogen-Ion Concentration, Wound Healing, Hydrogels
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