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Cited by 87Wound Healing and TreatmentsHydrogels: synthesis, properties, applicationsHemostasis and retained surgical items

An all-in-one “4a hydrogel”: Through first-aid hemostatic, antibacterial, antioxidant, and angiogenic to promoting infected wound healing

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Hu, Shanshan, Yang, Zixin, Zhai, Qiming, Li, Dize, Zhu, Xingyu, He, Qingqing, Li, Lingjie, Cannon, Richard D. +4 more·2023·Small
DOI 10.1002/smll.202207437
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Abstract

Currently used wound dressings are ineffective. Hence, there is a need to develop introduce a high‐performance medicament with multiple functions including rapid hemostasis and excellent antibacterial activity to meet the growing worldwide demand for wound healing products. Here, inspired by the strong adhesion of mussels and the enzyme‐mimicking activity of nanometallic biomaterials, the authors developed an injectable hydrogel to overcome multiple limitations of current wound dressings. The hydrogel is synthesized via esterification reaction between poly(vinyl alcohol) (PVA) and 3,4‐dihydroxyphenylalanine (DOPA), followed by catechol‐metal coordination between Cu 2+ and the catechol groups of DOPA to form a PVA‐DOPA‐Cu (PDPC) hydrogel. The PDPC hydrogel possesses excellent tissue adhesive, antioxidative, photothermal, antibacterial, and hemostatic properties. The hydrogel rapidly and efficiently stopped bleeding under different traumatic conditions, including otherwise‐lethal liver injury, high‐pressure carotid artery rupture, and even fatal cardiac penetration injuries in animal models. Furthermore, it is demonstrated that the PDPC hydrogel affected high‐performance wound repair and tissue regeneration by accelerating re‐epithelialization, promoting collagen deposition, regulating inflammation, and contributing to vascularization. The results show that PDPC hydrogel is a promising candidate for rapid hemorrhage control and efficient wound healing in multiple clinical applications.

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  • After injection at bleeding sites, PDPC hydrogels rapidly absorb blood and adhere tightly to the wound, forming an effective hemostatic barrier.

    “After injection at bleeding sites, the PDPC hydrogels can rapidly absorb blood and adhere tightly to the wound, forming an effective hemostatic barrier.”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [122]

    Section 2.5 (page not provided) says the PDPC hydrogel can absorb blood and that applying it to a bleeding site forms a tight barrier that rapidly seals the wound; animal tests also show rapid adhesion and hemostasis. Section 2.1 establishes that the hydrogel is injectable, but the hemostasis experiments describe applying it to wounds, not injecting it at the bleeding sites. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • PDPC hydrogels are effective in treating severe hemorrhages from liver injury, carotid artery rupture, and cardiac penetration injury.

    “They are effective in treating severe hemorrhages from liver injury, carotid artery rupture, and cardiac penetration injury.”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [122]

  • PDPC hydrogels exhibit antimicrobial and anti-inflammatory properties due to the DOPA/Cu2+ complex, showing potential in promoting diabetic wound healing.

    “In addition, owing to the existence of the DOPA/Cu2+ complex, PDPC hydrogels also exhibit antimicrobial and anti-inflammatory properties, showing great potential in promoting diabetic wound healing [122].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [122]

  • PDPC hydrogels exhibited high tissue adhesive performance and photothermal and antibacterial properties.

    “The PDPC hydrogels exhibited multiple functions, including high tissue adhesive performance and photothermal and antibacterial properties.”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [122]

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Cited by

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Authors
Hu, S., Yang, Z., Zhai, Q., Li, D., Zhu, X., He, Q., Li, L., Cannon, R. D., Wang, H., Tang, H., Ji, P., & Chen, T.
Affiliations
  • Stomatological Hospital of Chongqing Medical University (CN)
  • University of Otago (NZ)
  • Dalian University of Technology (CN)
Corresponding author
  • Tang, Han
  • Ji, Ping
  • Chen, Tao
ORCID
Venue
Small
Publisher
Wiley
Published
2023-03-28
Volume
19
Issue
27
Pages
e2207437-e2207437
ISSN
  • 1613-6810 (ISSN-L)
  • 1613-6829
DOI
10.1002/smll.202207437
OpenAlex
W4361285961
Cited by
87
References
0
Citations by year
2026: 13 · 2025: 29 · 2024: 38 · 2023: 7
FWCI
9.58
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Small (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (82101066, 81701031, 32071362)
  • China Postdoctoral Science Foundation (2020M683265, 2020M683266)
  • Natural Science Foundation of Chongqing (cstc2021jcyj‐bshX0140)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
Keywords
injectable hydrogel, wound healing, hemostasis, antibacterial activity, antioxidant activity, angiogenesis, polyvinyl alcohol, DOPA, mussel-inspired adhesion, photothermal therapy, wound dressings, re-epithelialization, collagen deposition, inflammation regulation, tissue regeneration, hemorrhage control
MeSH terms
Animals, Anti-Bacterial Agents, Antioxidants, Catechols, Hemostasis, Hemostatics, Wound Healing, Hydrogels

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