A Chlorin E6 Derivative-mediated Photodynamic Therapy for Patients with Cervical and Vaginal Low-grade Squamous Intraepithelial Lesions: A Retrospective Analysis
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Abstract Cervical and vaginal low‐grade squamous intraepithelial lesions (LSIL) are associated with persistent human papillomavirus infections, and require an efficacious non‐invasive treatment such as photodynamic therapy due to anatomical characteristics. In this study, we evaluated the clinical efficacy and safety of a chlorin e6 derivative named STBF‐mediated photodynamic therapy (STBF‐PDT) for patients with cervical and vaginal LSIL. A total of 18 patients received STBF‐PDT for 3 to 6 times and followed up for 6 to 12 months; among them, 6 had cervical and vaginal LSIL and 1 had vaginal stump LSIL after hysterectomy for cervical cancer. Results showed the complete remission (CR) rates were 72.22% (13/18), and the HPV remission rates and HPV clearance rates were 88.89% (16/18) and 83.33% (15/18), respectively at 1‐month follow‐up. The CR reached 88.89% and HPV remission rates got 94.44% at the 6‐month follow‐up. There were no recurrence cases so far, and no pain, heaving sensation, scar, deformity, and any other obvious adverse reactions occurred during treatment and follow‐up. In conclusion, STBF‐PDT is an effective, safe, and well‐tolerated method for the treatment of cervical and vaginal LSIL. It may have promising potential for applications in the future.
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A Ce6-derivative from Spirulina sp. used as a PS for cervical and vaginal low-grade squamous intraepithelial lesions associated with persistent HPV infection resulted in complete remission rates of 88.89% and HPV remission rates of 94.44% at 6-month follow-up.
“The results showed that the complete remission rates were 88.89% and the HPV remission rates was 94.44% at a 6-month follow-up.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [148]
No recurrence cases, pain, heaviness, scar, deformity, or other obvious adverse reactions occurred during treatment and follow-up for the Ce6-derivative PDT of LSIL.
“There were no recurrence cases, no pain, heaving sensation, scar, or deformity, and no other obvious adverse reactions occurred during the treatment and follow-up.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [148]
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Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp.
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Flexible Cervical Photodynamic Therapy Device
Jin, T., Li, Y., Li, Q., Hu, X., Zhang, J., & Luo, L. (2024) · Translational Biophotonics · doi:10.1002/tbio.70001
- Authors
- Yao, H., Yan, J., Zhou, Z., Shen, S., Wu, Y., Liu, P., Zhang, H., & Wang, X.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Zhang, Haiyan
- Wang, Xiuli
- Venue
- Translational Biophotonics
- Publisher
- Wiley
- Published
- 2022-07-19
- Volume
- 5
- Issue
- 1
- ISSN
- 2627-1850 (ISSN-L)
- OpenAlex
- W4283209801
- Cited by
- 6
- References
- 26
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Translational Biophotonics (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science and Technology Commission of Shanghai Municipality
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- photodynamic therapy, chlorin e6 derivatives, low-grade squamous intraepithelial lesion, cervical intraepithelial neoplasia, vaginal intraepithelial neoplasia, human papillomavirus, HPV clearance, treatment efficacy and safety, non-invasive treatment
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