The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
A third type of hydrogenase catalyzing H2 activation
Abstract
The activation of molecular hydrogen is of interest both from a chemical and biological viewpoint. The covalent bond of H 2 is strong (436 kJ mol−1). Its cleavage is catalyzed by metals or metal complexes in chemical hydrogenation reactions and by metalloenzymes named hydrogenases in microorganisms. Until recently only two types of hydrogenases are known, the [FeFe[‐hydrogenases and [NiFe[‐hydrogenases. Both types, which are phylogenetically unrelated, harbor in their active site a dinuclear metal center with intrinsic CO and cyanide ligands and contain iron–sulfur clusters for electron transport as revealed by their crystal structures. Fifteen years ago a third type of phylogenetically unrelated hydrogenase was discovered, which has a mononuclear iron active site and is devoid of iron–sulfur clusters. It was initially referred to as “metal free” hydrogenase, but was later renamed iron–sulfur cluster‐free hydrogenase or [Fe[‐hydrogenase. In this review, we introduce first the [FeFe[‐hydrogenases and [NiFe[‐hydrogenases, and then focus on the structure and function of the iron–sulfur cluster‐free hydrogenase (Hmd) and show that this enzyme contains an iron‐containing cofactor. The low‐spin iron is complexed by two intrinsic CO‐, one sulfur‐ and one or two N/O ligands and has one open coordination site, which is proposed to be the location of H 2 binding. © 2007 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 7: 37–46; 2007: Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/tcr.20111
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Cited by
Lubitz, W., Ogata, H., Rüdiger, O., & Reijerse, E. (2014) · Chemical Reviews · doi:10.1021/cr4005814 · Cited by 2,060
Hydrogen Evolution Catalyzed by Cobaloximes
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Radical S-Adenosylmethionine Enzymes
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The Crystal Structure of [Fe]-Hydrogenase Reveals the Geometry of the Active Site
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Self-citationOceanic nickel depletion and a methanogen famine before the Great Oxidation Event
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Metadata
- Authors
- Shima, S., & Thauer, R. K.
- Venue
- The Chemical Record
- Publisher
- Wiley
- Published
- 2007-01
- Volume
- 7
- Issue
- 1
- Pages
- 37-46
- ISSN
- 1527-8999 (ISSN-L)
- 1528-0691
- OpenAlex
- W1996624679
- Cited by
- 281
- References
- 45
- FWCI
- 20.50
- Type
- journal article
- Language
- en
- Open access
- closed
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