The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The Crystal Structure of [Fe]-Hydrogenase Reveals the Geometry of the Active Site
Abstract
Biological formation and consumption of molecular hydrogen (H 2 ) are catalyzed by hydrogenases, of which three phylogenetically unrelated types are known: [NiFe]-hydrogenases, [FeFe]-hydrogenases, and [Fe]-hydrogenase. We present a crystal structure of [Fe]-hydrogenase at 1.75 angstrom resolution, showing a mononuclear iron coordinated by the sulfur of cysteine 176, two carbon monoxide (CO) molecules, and the sp 2 -hybridized nitrogen of a 2-pyridinol compound with back-bonding properties similar to those of cyanide. The three-dimensional arrangement of the ligands is similar to that of thiolate, CO, and cyanide ligated to the low-spin iron in binuclear [NiFe]- and [FeFe]-hydrogenases, although the enzymes have evolved independently and the CO and cyanide ligands are not found in any other metalloenzyme. The related iron ligation pattern of hydrogenases exemplifies convergent evolution and presumably plays an essential role in H 2 activation. This finding may stimulate the ongoing synthesis of catalysts that could substitute for platinum in applications such as fuel cells.
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Cites
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Cited by
Molybdenum phosphide as an efficient electrocatalyst for the hydrogen evolution reaction
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First-row transition metal dichalcogenide catalysts for hydrogen evolution reaction
Kong, D., Cha, J. J., Wang, H., Lee, H. R., & Cui, Y. (2013) · Energy & Environmental Science · doi:10.1039/c3ee42413h · Cited by 1,031
Tang, T., Jiang, W.-J., Niu, S., Liu, N., Luo, H., Chen, Y.-Y., Jin, S.-F., Gao, F., Wan, L.-J., & Hu, J.-S. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b03507 · Cited by 880
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Efficient Dehydrogenation of Formic Acid Using an Iron Catalyst
Boddien, A., Mellmann, D., Gärtner, F., Jackstell, R., Junge, H., Dyson, P. J., Laurenczy, G., Ludwig, R., & Beller, M. (2011) · Science · doi:10.1126/science.1206613 · Cited by 832
Metadata
- Authors
- Shima, S., Pilak, O., Vogt, S., Schick, M., Stagni, M. S., Meyer-Klaucke, W., Warkentin, E., Thauer, R. K., & Ermler, U.
- Venue
- Science
- Published
- 2008-07-25
- Volume
- 321
- Issue
- 5888
- Pages
- 572-575
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039892768
- Cited by
- 608
- References
- 22
- FWCI
- 27.35
- Type
- journal article
- Language
- en
- Open access
- closed
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