The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Valproic acid
Abstract
Valproic acid use during pregnancy results in an absolute risk for spina bifida of 1–2%. This increased risk is comparable to the recurrence risk for neural tube defects and warrants informed counselling and access to prenatal diagnosis. There is no substantial evidence that valproic acid use increases the risk for other specific major malformations above the increased risk due to maternal epilepsy. Valproic acid may cause a characteristic pattern of minor facial malformations. Further definition and confirmation are required, and the magnitude of the risk needs to be determined. There are inadequate data to assess the magnitude, if any, of the risks for postnatal growth abnormalities and developmental disabilities associated with the use of valproic acid during pregnancy. Birth‐defect monitoring programs and international collaboration among the staffs of monitoring programs played a major role in determining that valproic acid is a human teratogen.
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Citations
Cites
MATERNAL VALPROIC ACID AND CONGENITAL NEURAL TUBE DEFECTS
Robert, E., & Guibaud, P. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90908-4 · Cited by 539
DiLiberti, J. H., Farndon, P. A., Dennis, N. R., & Curry, C. J. R. (1984) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320190308 · Cited by 399
Sodium Valproate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Epilepsy
Pinder, R. M., Brogden, R. N., Speight, T. M., & Avery, G. S. (1977) · Drugs · doi:10.2165/00003495-197713020-00001 · Cited by 315
Nakane, Y., Okuma, T., Takahashi, R., Sato, Y., Wada, T., Sato, T., Fukushima, Y., Kumashiro, H., Ono, T., Takahashi, T., et al. (1980) · Epilepsia · doi:10.1111/j.1528-1157.1980.tb04320.x · Cited by 301
VALPROIC ACID AND SPINA BIFIDA
Bjerkedal, T., Czeizel, A., Goujard, J., Kallen, B., Mastroiacova, P., Nevin, N., Oakley, G., & Robert, E. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90018-6 · Cited by 265
Self-citationFETAL HEAD GROWTH RETARDATION ASSOCIATED WITH MATERNAL ANTIEPILEPTIC DRUGS
Hiilesmaa, V. K., Teramo, K., Granström, M.-L., & Bardy, A. H. (1981) · The Lancet · doi:10.1016/s0140-6736(81)90354-8 · Cited by 167
Koch-Weser, J., & Browne, T. R. (1980) · New England Journal of Medicine · doi:10.1056/nejm198003203021204 · Cited by 167
Nau, H., Zierer, R., Spielmann, H., Neubert, D., & Gansau, C. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90541-5 · Cited by 166
Epilepsy, pregnancy and the child
Hughes, J. R. (1982) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(82)90053-0 · Cited by 165
Teratogenicity of valproic acid: In vivo and in vitro investigations
Kao, J., Brown, N. A., Schmid, B., Goulding, E. H., & Fabro, S. (1981) · Teratogenesis, Carcinogenesis, and Mutagenesis · doi:10.1002/tcm.1770010405 · Cited by 161
Cited by
Drugs in Pregnancy and Lactation
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-11-902_3 · Cited by 1,075
Wilson, R. D., Wilson, R. D., Désilets, V., Wyatt, P., Langlois, S., Gagnon, A., Allen, V., Blight, C., Johnson, J.-A., Audibert, F., et al. (2007) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32685-8 · Cited by 288
Neural tube defects—disorders of neurulation and related embryonic processes
Copp, A. J., & Greene, N. D. E. (2013) · WIREs Developmental Biology · doi:10.1002/wdev.71 · Cited by 268
Treatment of Mood Disorders During Pregnancy and Postpartum
Cohen, L. S., Wang, B., Nonacs, R., Viguera, A. C., Lemon, E. L., & Freeman, M. P. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.02.001 · Cited by 118
When a Uniquely Effective Drug is Teratogenic
Stern, R. S. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904133201510 · Cited by 86
Metadata
- Authors
- Lammer, E. J., Sever, L. E., & Oakley, G. P.
- Venue
- Teratology
- Publisher
- Wiley
- Published
- 1987-06
- Volume
- 35
- Issue
- 3
- Pages
- 465-473
- ISSN
- 0040-3709 (ISSN-L)
- 1096-9926
- OpenAlex
- W125743501
- Cited by
- 291
- References
- 29
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Valproic acid. https://app.cochat.ai/papers/10.1002/tera.1420350319
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- Lammer, E. J., Sever, L. E., & Oakley, G. P. (1987). Valproic acid. Teratology. https://doi.org/10.1002/tera.1420350319
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
