The DOI matches its Crossref record.
Valproic Acid
Abstract
Valproic acid (VPA) is an antiepileptic drug approved in 1978 by the United States Food and Drug Administration (FDA) for the treatment of absence seizures. VPA is a simple eight-carbon branched-chain fatty acid, which is structurally unrelated to any other marketed drug (Fig. 1). In the United States, tablets are marketed as VPA, and syrup is marketed as the sodium salt of VPA (sodium valproate). Tablets of the sodium and magnesium salts of VPA and an amide form of VPA are marketed in some foreign countries.Mechanism of ActionVPA suppresses seizure activity in many animal models of epilepsy and . . .
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Citations
Cited by
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
Fromenty, B., & Pessayre, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00012-6 · Cited by 665
Valproate–Induced Hepatic Injury: Analyses of 23 Fatal Cases
Zimmerman, H. J., & Ishak, K. G. (1982) · Hepatology · doi:10.1002/hep.1840020513 · Cited by 393
Mechanism of anticonvulsant action of valproate
Chapman, A., Keane, P. E., Meldrum, B. S., Simiand, J., & Vernieres, J. C. (1982) · Progress in Neurobiology · doi:10.1016/0301-0082(82)90010-7 · Cited by 337
Lammer, E. J., Sever, L. E., & Oakley, G. P. (1987) · Teratology · doi:10.1002/tera.1420350319 · Cited by 291
Metadata
- Authors
- Koch-Weser, J., & Browne, T. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-03-20
- Volume
- 302
- Issue
- 12
- Pages
- 661-666
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2439131907
- Cited by
- 167
- References
- 0
- FWCI
- 18.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Valproic Acid. https://app.cochat.ai/papers/10.1056/nejm198003203021204
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- Koch-Weser, J., & Browne, T. R. (1980). Valproic Acid. New England Journal of Medicine. https://doi.org/10.1056/nejm198003203021204
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
