The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The effect of age on osteogenic, adipogenic and proliferative potential of female adipose-derived stem cells
Abstract
Human adipose tissue is an ideal source of autologous cells that is both plentiful and easily obtainable in large quantities through the simple surgical procedure of liposuction. The stromal vascular fraction of adipose tissue contains a stem cell population, adipose-derived stem cells (ASCs), capable of adipogenic, osteogenic, myogenic and chondrogenic differentiation. These cells have already been recognized to possess great therapeutic potential in tissue engineering and regeneration. In this study, we sought to determine the effect of donor age on the growth kinetics and differentiation potential of ASCs. For this, ASCs were isolated from liposuctioned adipose tissue obtained from female patients in the age range 20-58 years. Population doubling time was calculated over 2 weeks and differentiation potential was determined by assaying for adipogenesis and osteogenesis. ASCs obtained from older donors appeared to have a slower rate of proliferation, but this relationship was not significant. While adipogenic potential was unrelated to donor age, a distinct relationship between donor age and osteogenic potential was observed. The aetiology of this age-dependent change in osteogenic potential was not due to any changes in the number of precursors with osteogenic capacity in the adipose sample. These findings have important implications for emerging cell-based therapeutic strategies, such as tissue engineering, in addition to treatment of various metabolic bone disorders including osteoporosis.
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Cites
Adipogenesis and aging: does aging make fat go MAD
Kirkland, J. L., Tchkonia, T., Pirtskhalava, T., Han, J., & Karagiannides, I. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00014-1 · Cited by 339
Aging in adipocytes: Potential impact of inherent, depot-specific mechanisms
CARTWRIGHT, M., TCHKONIA, T., & KIRKLAND, J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.003 · Cited by 318 · cited 1×
“DOI: 10.1002/term colleagues, who measured peaks in adipogenic capacity in donors aged up to 70 years (for review, see Cartwright et al., 2007).”
InfluentialAge, anatomic site, and the replication and differentiation of adipocyte precursors
Kirkland, J. L., Hollenberg, C. H., & Gillon, W. S. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.2.c206 · Cited by 180
Kirkland, J. L., & Dobson, D. E. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb02967.x · Cited by 105
Cited by
Choudhery, M. S., Badowski, M., Muise, A., Pierce, J., & Harris, D. T. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-8 · Cited by 529
The Potential of Adipose Stem Cells in Regenerative Medicine
Lindroos, B., Suuronen, R., & Miettinen, S. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9193-7 · Cited by 441
Beane, O. S., Fonseca, V. C., Cooper, L. L., Koren, G., & Darling, E. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115963 · Cited by 323
Adipose tissue aging: mechanisms and therapeutic implications
Ou, M.-Y., Zhang, H., Tan, P.-C., Zhou, S.-B., & Li, Q.-F. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-04752-6 · Cited by 300
Yarahmadi, A., Dorri Giv, M., Hosseininejad, R., Rezaie, A., Mohammadi, N., Afkhami, H., & Farokhi, A. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1472679 · Cited by 21
Metadata
- Authors
- Zhu, M., Kohan, E., Bradley, J., Hedrick, M., Benhaim, P., & Zuk, P.
- Venue
- Journal of Tissue Engineering and Regenerative Medicine
- Publisher
- Hindawi Limited
- Published
- 2009-06
- Volume
- 3
- Issue
- 4
- Pages
- 290-301
- ISSN
- 1932-6254 (ISSN-L)
- 1932-7005
- OpenAlex
- W1995281971
- Cited by
- 184
- References
- 4
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhu, M., Kohan, E., Bradley, J., Hedrick, M., Benhaim, P., & Zuk, P. (2009). The effect of age on osteogenic, adipogenic and proliferative potential of female adipose-derived stem cells. Journal of Tissue Engineering and Regenerative Medicine. https://doi.org/10.1002/term.165
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