The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Adipose tissue aging: mechanisms and therapeutic implications
Open accessAbstract
Adipose tissue, which is the crucial energy reservoir and endocrine organ for the maintenance of systemic glucose, lipid, and energy homeostasis, undergoes significant changes during aging. These changes cause physiological declines and age-related disease in the elderly population. Here, we review the age-related changes in adipose tissue at multiple levels and highlight the underlying mechanisms regulating the aging process. We also discuss the pathogenic pathways of age-related fat dysfunctions and their systemic negative consequences, such as dyslipidemia, chronic general inflammation, insulin resistance, and type 2 diabetes (T2D). Age-related changes in adipose tissue involve redistribution of deposits and composition, in parallel with the functional decline of adipocyte progenitors and accumulation of senescent cells. Multiple pathogenic pathways induce defective adipogenesis, inflammation, aberrant adipocytokine production, and insulin resistance, leading to adipose tissue dysfunction. Changes in gene expression and extracellular signaling molecules regulate the aging process of adipose tissue through various pathways. In addition, adipose tissue aging impacts other organs that are infiltrated by lipids, which leads to systemic inflammation, metabolic system disruption, and aging process acceleration. Moreover, studies have indicated that adipose aging is an early onset event in aging and a potential target to extend lifespan. Together, we suggest that adipose tissue plays a key role in the aging process and is a therapeutic target for the treatment of age-related disease, which deserves further study to advance relevant knowledge.
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Cites
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Self-citationClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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Cited by
Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity
Horwitz, A., & Birk, R. (2023) · Nutrients · doi:10.3390/nu15153445 · Cited by 143
Adipose tissue aging is regulated by an altered immune system
Zhang, Y.-X., Ou, M.-Y., Yang, Z.-H., Sun, Y., Li, Q.-F., & Zhou, S.-B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125395 · Cited by 62
Self-citationFang, Y., Medina, D., Stockwell, R., McFadden, S., Quinn, K., Peck, M. R., Bartke, A., Hascup, K. N., & Hascup, E. R. (2021) · doi:10.1101/2021.11.08.467509 · Cited by 53
(2023) · doi:10.1007/s11357-023-00843-0 · Cited by 53
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46
Metadata
- Authors
- Ou, M.-Y., Zhang, H., Tan, P.-C., Zhou, S.-B., & Li, Q.-F.
- Venue
- Cell Death & Disease
- Published
- 2022-04-04
- Volume
- 13
- Issue
- 4
- Pages
- 300-300
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W4223485052
- Cited by
- 300
- References
- 155
- FWCI
- 28.23
- Type
- journal article
- Language
- en
- Open access
- gold
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