The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months
Open accessAbstract
Among autologous somatic stem cells, bone marrow-derived mesenchymal stem cells (BMSCs) are the most widely used worldwide to repair not only mesenchymal tissues (bone, cartilage) but also many other kinds of tissues, including heart, skin, and liver. Autologous BMSCs are thought to be safe because of the absence of immunological reaction and disease transmission. However, it is possible that they will form tumours during long-term follow-up. In 1988, we transplanted autologous BMSCs to repair articular cartilage, which was the first such trial ever reported. Subsequently we performed this procedure in about 40 patients. Demonstration that neither partial infections nor tumours appeared in these patients provided strong evidence for the safety of autologous BMSC transplantation. Thus, in this study we checked these patients for tumour development and infections. Between January 1998 and November 2008, 41 patients received 45 transplantations. We checked their records until their last visit. We telephoned or mailed the patients who had not visited the clinics recently to establish whether there were any abnormalities in the operated joints. Neither tumours nor infections were observed between 5 and 137 (mean 75) months of follow-up. Autologous BMSC transplantation is a safe procedure and will be widely used around the world.
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Cited by
J. Centeno, C., R. Schultz, J., Cheever, M., Freeman, M., Faulkner, S., Robinson, B., & Hanson, R. (2011) · Current Stem Cell Research & Therapy · doi:10.2174/157488811797904371 · Cited by 234
Awad, M. E., Hussein, K. A., Helwa, I., Abdelsamid, M. F., Aguilar-Perez, A., Mohsen, I., Hunter, M., Hamrick, M. W., Isales, C. M., Elsalanty, M., et al. (2019) · Stem Cells International · doi:10.1155/2019/3826054 · Cited by 39
Eder, C., Schmidt-Bleek, K., Geissler, S., Sass, F. A., Maleitzke, T., Pumberger, M., Perka, C., Duda, G. N., & Winkler, T. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05428-0 · Cited by 33
Metadata
- Authors
- Wakitani, S., Okabe, T., Horibe, S., Mitsuoka, T., Saito, M., Koyama, T., Nawata, M., Tensho, K., Kato, H., Uematsu, K., Kuroda, R., Kurosaka, M., Yoshiya, S., Hattori, K., & Ohgushi, H.
- Venue
- Journal of Tissue Engineering and Regenerative Medicine
- Publisher
- Hindawi Limited
- Published
- 2011-01-26
- Volume
- 5
- Issue
- 2
- Pages
- 146-150
- ISSN
- 1932-6254 (ISSN-L)
- OpenAlex
- W2085163273
- Cited by
- 323
- References
- 1
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Wakitani, S., Okabe, T., Horibe, S., Mitsuoka, T., Saito, M., Koyama, T., Nawata, M., Tensho, K., Kato, H., Uematsu, K., Kuroda, R., Kurosaka, M., Yoshiya, S., Hattori, K., & Ohgushi, H. (2011). Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. Journal of Tissue Engineering and Regenerative Medicine. https://doi.org/10.1002/term.299
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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