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Cited by 39Osteoarthritis Treatment and MechanismsMesenchymal stem cell researchPeriodontal Regeneration and Treatments

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Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment

Open access
Awad, Mohamed E., Hussein, Khaled A., Helwa, Inas, Abdelsamid, Mohamed F., Aguilar-Perez, Alexandra, Mohsen, Ibrahim, Hunter, Monte, Hamrick, Mark W., Isales, Carlos M., Elsalanty, Mohammed, Hill, William D., Fulzele, Sadanand·2019·Stem Cells International
DOI 10.1155/2019/3826054PMC PMC6476108
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Abstract

The aim of this study is to review all the published clinical trials on autologous bone marrow mesenchymal stem cells (BM-MSCs) in the repair of cartilage lesions of the knee. We performed a comprehensive search in three electronic databases: PubMed, Medline via Ovid, and Web of Science. A systematic review was conducted according to the guidelines of PRISMA protocol and the Cochrane Handbook for Systematic Reviews of Interventions. The modified Coleman methodology score was used to assess the quality of the included studies. Meta-analysis was conducted to estimate the effect size for Pain and function change after receiving BM-MSCs. Thirty-three studies—including 724 patients of mean age 44.2 years—were eligible. 50.7% of the included patients received cultured BM-MSCs for knee cartilage repair. There was improvement in the MINORS quality score over time with a positive correlation with the publication year. Meta-analysis indicated better improvement and statistical significance in the Visual Analog Scale for Pain, IKDC Function, Tegner Activity Scale, and Lysholm Knee Score after administration of noncultured BM-MSCs when compared to evaluation before the treatment. Meanwhile, there was a clear methodological defect in most studies with an average modified Coleman methodology score (MCMS) of 55. BM-MSCs revealed a clinically relevant improvement in pain, function, and histological regeneration.

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  • Leukocyte-poor PRP may be superior for tendinopathy, whereas leukocyte-rich PRP may be more effective in ligament and cartilage repair.

    “Some evidence suggests leukocyte-poor PRP may be superior for tendinopathy, whereas leukocyte-rich PRP may be more effective in ligament and cartilage repair [97].”

    From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [97]

    The Discussion describes platelet-rich fibrin glue used with stem cells for cartilage defects, and §5.4 mentions PRP as a possible additional agent. Neither passage compares leukocyte-poor with leukocyte-rich PRP or addresses tendinopathy and ligament repair; searches for those terms found no supporting passage. Page numbers were not available in our copy. (LLM, conf=0.76)

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Metadata

Authors
Awad, M. E., Hussein, K. A., Helwa, I., Abdelsamid, M. F., Aguilar-Perez, A., Mohsen, I., Hunter, M., Hamrick, M. W., Isales, C. M., Elsalanty, M., Hill, W. D., & Fulzele, S.
Affiliations
  • Augusta University (US)
  • National Research Centre (EG)
  • Misr International University (EG)
  • Mayo Clinic (US)
  • Anatomy and Cell Biology Department-Indiana University School of Medicine, Indianapolis, IN, USA
  • Fayoum University (EG)
  • Medical University of South Carolina (US)
Corresponding author
  • Hill, William D.
  • Fulzele, Sadanand
ORCID
Venue
Stem Cells International
Publisher
Wiley
Published
2019-04-07
Volume
2019
Pages
1-15
ISSN
  • 1687-966X (ISSN-L)
  • 1687-9678
DOI
10.1155/2019/3826054
PMC
PMC6476108
OpenAlex
W2934303176
Cited by
39
References
2
Citations by year
2026: 1 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 2
FWCI
1.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Stem Cells International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords
autologous bone marrow mesenchymal stem cells, knee cartilage repair, cartilage damage, pain outcomes, knee function, cartilage regeneration, study quality assessment, IKDC score, Lysholm score, Tegner score

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