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Acute toxicity, mutagenicity, and estrogenicity of bisphenol‐A and other bisphenols

Chen, Min‐Yu, Ike, Michihiko, Fujita, Masanori·2002·Environmental Toxicology

Abstract

Although abundant data are available on the toxicity of bisphenol‐A (2,2‐bis (4‐hydroxydiphenyl)propane; BPA), little is known about the toxicities of the structurally similar compounds, namely bisphenols (BPs). A variety of BPs were examined for their acute toxicity against Daphnia magna, mutagenicity, and estrogenic activity using the Daphtoxkit (Creasel Ltd.), the umu test system, and the yeast two‐hybrid system, respectively, in comparison with BPA. BPA was moderately toxic to D. magna (48‐h EC 50 was 10 mg/l) according to the current U.S. EPA acute toxicity evaluation standard, and it was weakly estrogenic with 5 orders of magnitude lower activity than that of the natural estrogen 17β‐estradiol in the yeast screen, while no mutagenicity was observed. All seven BPs tested here showed moderate to slight acute toxicity, no mutagenicity, and weak estrogenic activity as well as BPA. Some of the BPs showed considerably higher estrogenic activity than BPA, and others exhibited much lower activity. Among the tested BPs, two compounds, i.e., bisphenol‐S (bis(4‐hydroxydiphenyl)sulfone) and bis(4‐hydroxyphenyl)sulfide, have never been reported for their estrogenic activity previously. © 2002 by Wiley Periodicals, Inc. Environ Toxicol 17: 80–86, 2002

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Metadata

Authors
Chen, M., Ike, M., & Fujita, M.
Venue
Environmental Toxicology
Publisher
Wiley
Published
2002-01
Volume
17
Issue
1
Pages
80-86
ISSN
  • 1520-4081 (ISSN-L)
  • 1522-7278
OpenAlex
W2041609470
Cited by
508
References
20
FWCI
1.72
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Acute toxicity, mutagenicity, and estrogenicity of bisphenol‐A and other bisphenols. https://app.cochat.ai/papers/10.1002/tox.10035
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Chen, M., Ike, M., & Fujita, M. (2002). Acute toxicity, mutagenicity, and estrogenicity of bisphenol‐A and other bisphenols. Environmental Toxicology. https://doi.org/10.1002/tox.10035

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