Alzheimer’s disease drug development pipeline: 2024

Cummings, Jeffrey, Zhou, Yadi, Lee, Garam, Zhong, Kate, Fonseca, Jorge, Cheng, Feixiong·2024·Alzheimer's & Dementia: Translational Research & Clinical Interventions

Cited by (334)

Items 101–200 of 334

  1. Anti-amyloid treatments in Alzheimer’s disease: elegance, evidence and ethics
    Timothy P Daly, Andi Olluri, Markku Tapio Kurkinen · 2024 · Advances in Clinical and Experimental Medicine
  2. Discovery of structurally intriguing diterpenoids as anti-neuroinflammatory agents from mangrove plant Excoecaria agallocha L. via inhibiting macrophage polarization and inflammasome
    Junyi Li, Mingbin Chen, Tingting Fu, Fei‐Fei Liu, Jin Liu, Congjun Xu, Jing Zhou, Yong Rao, Zhongping Jiang, Ling Huang · 2025 · Phytochemistry
  3. Long‐term value of lecanemab to individuals and families
    Bryan Tysinger, Yifan Wei, Hanke Heun‐Johnson, Julie Zissimopoulos · 2025 · Alzheimer s & Dementia Translational Research & Clinical Interventions
  4. Basic approach on the protective effects of hesperidin and naringin in Alzheimer’s disease
    Müjgan Kuşi, Eda Becer, Seda Vatansever · 2024 · Nutritional Neuroscience
  5. Commonly prescribed multi‐medication therapies exert sex‐specific effects on Alzheimer's disease pathology and metabolomic profiles in App NL‐G‐F mice: Implications for personalized therapeutics in aging
    Francesca Eroli, Kristina Johnell, Zeynep Acararicin, Christina Tsagkogianni, Stefania Zerial, Saverio Lancia, María Latorre‐Leal, Vilma Alanko, Sarah Nicole Hilmer, Anna Matton et al. · 2025 · Alzheimer s & Dementia
  6. Identifying RAGE inhibitors as potential therapeutics for Alzheimer’s disease via integrated in-silico approaches
    Inderjeet Bhogal, Vaishali Pankaj, Sudeep Roy · 2025 · Scientific Reports
  7. From suspicion of cognitive decline to dementia diagnosis: a systematic review of healthcare professionals’ considerations and attitudes
    Fleur C W Visser, Marleen Kloppenburg-Lagendijk, Liesbeth Hempenius, Nicolaas A. Verwey, Marieke Perry, Marlise E. A. van Eersel, Barbara C. Van Munster · 2025 · Age and Ageing
  8. Early Alzheimer's diagnosis: U.S. primary care physicians and use of blood biomarkers
    Jeffrey Murray Burns, Susan Alford, Justine Coppinger, Martí Jiménez‐Mausbach, Sutapa Ray, Hemant Pandey, Rosemary D. Laird · 2026 · Alzheimer s & Dementia
  9. Potential therapeutic targets for trauma management
    Zizheng Li, Ou Qiao, Yuru Wang, Ning Li, Yanhua Gong · 2023 · Trends in Pharmacological Sciences
  10. Etiology of Late-Onset Alzheimer’s Disease, Biomarker Efficacy, and the Role of Machine Learning in Stage Diagnosis
    Manash Sarma, Subarna Chatterjee · 2024 · Diagnostics
  11. Advances of therapeutic strategies for Alzheimer’s disease
    Xing Guo, Rui-zhu Yue, Zhen Cui, Shuying Wang, Tian Jia, Wenqiang Li, Wei Zhang, Linlin Shan, Chaokun Li · 2025 · Journal of Neurology
  12. Developing theragnostics for Alzheimer's disease: Insights from cancer treatment
    Hyunju Lee, Hee-Jeong Choi, Yoo Joo Jeong, Y. Na, Jin Tae Hong, Ji Min Han, Hyang‐Sook Hoe, Key‐Hwan Lim · 2024 · International Journal of Biological Macromolecules
  13. Zooming in on brain inflammation in Alzheimer’s disease
    Wiesje M. van der Flier, Michael Thomas Heneka · 2025 · Brain
  14. Oxidative Stress and the Role of Immune Cells in Alzheimer’s Disease: Therapeutic Implications and Future Perspectives
    Nidhi Puranik, Minseok Song · 2025 · CNS & Neurological Disorders - Drug Targets
  15. Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations
    Zijiao Liu, Jun Zhang, Fei Jiang, Cong Liu, Yaping Shao, Weidong Le · 2025 · CNS Neuroscience & Therapeutics
  16. CD2AP at the junction of nephropathy and Alzheimer’s disease
    Milène Vandal, Mohsen Janmaleki, Isabel M. Rea, Colin Gunn, Sotaro Hirai, Jeff A. Biernaskie, Justin Chun, Grant Robert Gordon, Andréy S. Shaw, Amir Sanati‐Nezhad et al. · 2025 · Molecular Neurodegeneration
  17. Societal Costs and Efficiency of Subcutaneous versus Intravenous Lecanemab in Early Alzheimer’s Disease: A U.S. Cost Comparison Model
    Amir Abbas Tahami Monfared, S. Barrows, Lindsey Fox, Brittney Herbel, William L. Herring, Alisha Krumbach, Quanwu Zhang · 2025 · Neurology and Therapy
  18. A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers
    Rodríguez, Andrés, Calero, Olga, Veiga, Sergio, Menacho-Román, Miriam, Arribas, Ignacio, Cano, Lluís, García-Ribas, Guillermo, Calero, Miguel · 2025 · Alzheimer's Research & Therapy
  19. Structure–activity relationship of GSK-3β inhibitors: insight into drug design for Alzheimer's disease
    G. Rajamani, S.N.H. Naqvi, Abha Sharma · 2025 · RSC Medicinal Chemistry
  20. P2Y1 receptor in Alzheimer’s disease
    Shan Luo, Yifei Wang, Tatsuhiro Hisatsune · 2024 · Neural Regeneration Research
  21. Exploring the diversity of cannabis cannabinoid and non-cannabinoid compounds and their roles in Alzheimer's disease: A review
    Hanane Doumar, Hicham El Mostafi, Aboubaker Elhessni, Mohamed Ebn Touhami, Abdelhalem Mesfioui · 2024 · IBRO Neuroscience Reports
  22. Electrophysiological insights into Alzheimer's disease: A review of human and animal studies
    Kirsten Calvin, Adam M. McNeela, Amanda M. Leisgang Osse, Guncha Bhasin, Matthew Ridenour, Jefferson W. Kinney, J.M. Hyman · 2024 · Neuroscience & Biobehavioral Reviews
  23. Harnessing artificial intelligence to transform Alzheimer’s disease research
    Sandrine Andrieu, Randall John Bateman, Erika Bereczki, Niranjan Bose, Anthony J. Brookes, Pudugramam Murali Doraiswamy, Miia Kivipelto, Susan L. Kohlhaas, Lampros C. Kourtis, Lefkos T. Middleton et al. · 2025 · Nature Medicine
  24. Clinically meaningful benefit and real‐world evidence in Alzheimer's disease research and care
    Robert Perneczky, Lutz Froelich · 2025 · Alzheimer s & Dementia Translational Research & Clinical Interventions
  25. microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients
    Penning, Amber, Snoeck, Sarah, Ormaechea, Olmo Ruiz, Ayyildiz, Dilara, Polzer, Oliver, Buitrago-Arango, Martin, Capobianco, Raffaella, de Winter, Fred, Balusu, Sriram, Verhaagen, Joost et al. · 2026 · Acta Neuropathologica Communications
  26. Understanding recent advances in non‐amyloid/non‐tau (NANT) biomarkers and therapeutic targets in Alzheimer's disease
    Linda J. Van Eldik, Eric Siemers, Emily C. Collins, Michael Gold, David B. Henley, Peter Johannsen, Hans Jörg Möbius, Melanie B. Shulman, Jin Zhou, Marı́a C. Carrillo et al. · 2024 · Alzheimer s & Dementia Translational Research & Clinical Interventions
  27. Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation
    Marta Matuszewska, Anna Wilkaniec, Magdalena Gąssowska-Dobrowolska, Magdalena Cieślik, Gabriela Olech-Kochańczyk, Ewelina Pałasz, Elżbieta Gawinek, Marcin Strawski, Grzegorz Arkadiusz Czapski · 2025 · Frontiers in Molecular Neuroscience
  28. Alzheimer’s disease and memantine effects on NMDA-receptor blockade: non-invasive in vivo insights from magnetoencephalography
    Juliette H. Lanskey, Amirhossein Jafarian, Laura E. Hughes, Melek Karadag, Ece Kocagöncü, Matthew A Rouse, Natalie Adams, Michelle Naessens, Vanessa Raymont, Mark W. Woolrich et al. · 2025 · Molecular Psychiatry
  29. Calcium and Non-Penetrating Traumatic Brain Injury: A Proposal for the Implementation of an Early Therapeutic Treatment for Initial Head Insults
    Danton H. O’Day · 2024 · Biomolecules
  30. Olfactory Ecto-Mesenchymal Stem Cells in Modeling and Treating Alzheimer’s Disease
    Hongmin Wang, Abena Dwamena · 2024 · International Journal of Molecular Sciences
  31. Emerging Novel Therapeutic Approaches for the Treatment of Alzheimer’s Disease
    A. Panwar, Mohd Imran Khan, Rajesh Kumar, Rakesh Kumar, Santosh Kumar Rai, Anil Kumar · 2024 · Advances in Alzheimer's Disease
  32. Towards a new Value-based scenario for the management of dementia in Italy: a SINdem delphi consensus study
    Camillo Marra, Flavia Beccia, Paolo Caffarra, Federica L’Abbate, Federica Agosta, Alberto Benussi, Laura Bonanni, Amalia Cecilia Bruni, Giuseppe Bruno, Stefano Francesco Cappa et al. · 2025 · Neurological Sciences
  33. TCnet: A Novel Strategy to Predict Target Combination of Alzheimer’s Disease via Network-Based Methods
    Chengyuan Yue, Baiyu Chen, Fei Pan, Ze Wang, Hongbo Yu, Guixia Liu, Weihua Li, Rui Wang, Yun Tang · 2025 · Journal of Chemical Information and Modeling
  34. Comparing and combining TSPO-PET tracers in tauopathies
    Harry Crook, Nicolai Franzmeier, Nesrine Rahmouni, Johannes S. Gnörich, Tim D. Fryer, Young T. Hong, Sebastian Niclas Roemer, Carla Palleis, Alexandra Strauss, Peter Simon Jones et al. · 2025 · European Journal of Nuclear Medicine and Molecular Imaging
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    So Yeon Jeon, Min Soo Byun, Hye Ji Choi, Yoon Hee Kim, Chung Hee Gwag, Yoonseok Oh, Jee Eun Park, Dahyun Yi, Gijung Jung, Hyejin Ahn et al. · 2025 · Alzheimer s & Dementia
  36. Papaverine-Derived Dual-Active Modulator Ameliorates Alzheimer’s Disease Pathology in Aged APP/PSEN1 Transgenic Mice
    Ashish Kumar, Madhu Ramesh, Jikesh Bhoi, Thimmaiah Govindaraju · 2025 · Journal of Medicinal Chemistry
  37. Development and Fabrication of Mesoporous Silica Nanoparticle Loaded in Situ Nasal Gel of Scutellarin for Alzheimer’s Disease
    Someshwar Dattatraya Mankar, Prashika Shinde, Suhas Shivaji Siddheshwar · 2026 · BioNanoScience
  38. Plasma eMTBR-tau243 and %p-tau217 for Biological Staging of Alzheimer Disease
    Gemma Salvadó, Kanta Horie, Nicolas R. Barthélemy, Suzanne E. Schindler, Shorena Janelidze, Anna Orduña Dolado, Divya Bali, Richard J. Perrin, John C. Morris, Tammie L.S. Benzinger et al. · 2026 · JAMA Neurology
  39. PLAN—Dementia literacy education and navigation for Korean elders with probable dementia and their caregivers: Rationale, methods, and design of a community-based, randomized, controlled, multi-site clinical trial
    Hae-Ra Han, Nancy Perrin, Simona C. Kwon, Jin Hui Joo, Ji-Young Yun, Deborah Min, Hochang Benjamin Lee · 2024 · Contemporary Clinical Trials
  40. Factors associated with adherence to tablet‐based cognitive training: J‐MINT study
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  41. Amyloid immunotherapy for Alzheimer's disease: the case for cautious adoption
    Jonathan M. Schott, Charles R. Marshall · 2025 · Arquivos de Neuro-Psiquiatria
  42. Alzheimer’s Dementia Targeting by Plant-Derived 2,6-Dimethoxybenzoic Acid: In vitro, DFT and Molecular Docking Study
    E. Eunice, Johanan Christian Prasana · 2025 · Asian Journal of Chemistry
  43. Integrative snRNA‐seq, molecular docking and dynamics simulations identifies Lasmiditan as drug candidate for Alzheimer's disease
    Martin C. Nwadiugwu, Md. Selim Reza, Boluwatife Afolabi, Demetrius M. Maraganore, Hui Shen, Hong‐Wen Deng · 2025 · Clinical and Translational Medicine
  44. Significance of NMDA receptor-targeting compounds in neuropsychological disorders: An in-depth review
    Fatemeh Forouzanfar, Amir Mahmoud Ahmadzadeh, Ali Mohammad Pourbagher‐Shahri, Ali Gorji · 2025 · European Journal of Pharmacology
  45. The Efficacy of Anti-amyloid Monoclonal Antibodies in Early Alzheimer’s Dementia: A Systematic Review
    Alyaa Mostafa, Stephanie Tiu, Farooq Ahmed Khan, Nusrath A Baig · 2025 · Annals of Indian Academy of Neurology
  46. Alzheimer’s disease and the mathematical mind
    Travis Thompson, Bradley Z. Vigil, Robert S. K. Young · 2024 · Brain Multiphysics
  47. An Overview of Glutaminyl Cyclase as a Promising Drug Target for Alzheimer’s Disease
    Rasajna Madhusudhana, Emily Boyle, Yana Cen · 2025 · Biomedicines
  48. Synthetic control methods for n‐of‐1 and parallel‐group trials in Alzheimer's disease: A proof‐of‐concept study using the I‐CONECT
    Chao‐Yi Wu, Liu Chen, John R. Dickson, Bo Zhang, Steven Edward Arnold, Hiroko Hayama Dodge · 2025 · Alzheimer s & Dementia
  49. Preclinical evidence and potential mechanisms of tanshinone ⅡA on cognitive function in animal models of Alzheimer’s disease: a systematic review and meta-analysis
    Yuanhang Rong, Qinqing Li, Yuzhong Du, Wenting Wang, Wenna Su, Junlong Zhang, Wenbin He · 2025 · Frontiers in Pharmacology
  50. Rivastigmine Templates with Antioxidant Motifs—A Medicinal Chemist’s Toolbox Towards New Multipotent AD Drugs
    Inês Dias, Marlène Emmanuel, Paul Vogt, Catarina Guerreiro-Oliveira, Inês Melo-Marques, Sandra M. Cardoso, Rita Cardoso Guedes, Sı́lvia Chaves, Maria Amélia Santos · 2025 · Antioxidants
  51. Design, Synthesis and Biological Evaluation of Chromeno[3,4- b ]xanthones as Multifunctional Agents for Alzheimer’s Disease
    Daniela Malafaia, Natércia F. Brás, Anna Sampietro, Inês Quintelas, Pedro Ferreira, Lúcia Melo, Joana Saavedra, Loreto Martínez‐González, Marisa Pereira, Jéssica Sarabando et al. · 2025 · ACS Chemical Neuroscience
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    Laura Pineiro‐Alonso, Inés Rubio-Prego, Ana M. López-Estévez, Pablo Garrido‐Gil, Rita Valenzuela, José Luis Labandeira-García, Pablo Aguiar, Ana Isabel Rodriguez-Perez, Marı́a José Alonso · 2025 · Drug Delivery and Translational Research
  53. The involvement of HIF-1α–dependent paracrine factors in Alzheimer’s disease
    Victoria I. Zhdankina, Elizaveta S Perepelitsa, Anna V. Blagova, Yulia K. Komleva, Tatiana I. Baranich, Alla B. Salmina · 2025 · Reviews in the Neurosciences
  54. Targeting Oligodendrocyte Dysfunction in Alzheimer’s Disease: a New Frontier for Drug Repurposing with Antihistamines and Serotonin Receptor Agonists
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  55. Interplay between CD33 and TREM2 in Alzheimer’s Disease: Potential Mechanistic Insights into Microglial Function in Amyloid Pathology
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  56. Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model
    Julia Neuharth, K. Hernandez, J. Bernholtz, Hadley Edwards, Adele Stewart · 2025 · Biology of Sex Differences
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  58. Advances in the drug treatment of Alzheimer’s disease: pathophysiology and mechanisms of action
    Joseph Nowell, Harry Crook, Mony J. de Leon, Paul Edison · 2026 · BMJ
  59. A new era in neuropharmacology: assessing the efficacy and safety of novel anti-amyloid and non-amyloid drug targets for Alzheimer's disease
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