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Cited by 17

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Creatine monohydrate pilot in Alzheimer’s: feasibility, brain creatine, and cognition

Smith, Aaron N., Choi, In‐Young, Lee, Phil, Sullivan, Debra K., Burns, Jeffrey M., Swerdlow, Russell H., Kelly, Emma, Taylor, Matthew K.·2025·Alzheimer's & Dementia: Translational Research & Clinical Interventions
DOI 10.1002/trc2.70101
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Abstract

BACKGROUND: Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. However, there is currently no clinical evidence demonstrating the effects of CrM in patients with AD. METHODS: In this single‐arm pilot trial, we investigated the feasibility of 20 g/day CrM for 8 weeks in 20 patients with AD. We measured compliance throughout; serum creatine at baseline, 4 weeks, and 8 weeks; and brain total creatine (tCr) and cognition (National Institutes of Health [NIH] Toolbox, Mini‐Mental State Examination [MMSE]) at baseline and 8 weeks. RESULTS: Nineteen participants achieved the target of ≥80% compliance with the CrM intervention. Serum Cr was elevated at 4 and 8 weeks ( p < .001) and brain tCr increased by 11% ( p < .001). Cognition improved on global ( p = .02) and fluid ( p = .004) composites, List Sorting ( p = .001), Oral Reading ( p < .001), and Flanker ( p = .05) tests. DISCUSSION: Our data suggest that CrM supplementation is feasible in AD and provides preliminary evidence for future efficacy and mechanism studies. Trial Registration: ClinicalTrials.gov, NCT05383833, registered on May 20, 2022. Highlights: Creatine monohydrate supplementation was feasible in patients with Alzheimer's disease. Creatine monohydrate was associated with increased brain total creatine. Creatine monohydrate was associated with improvements in cognition. Efficacy of creatine monohydrate in Alzheimer's disease should be studied further.

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Metadata

Authors
Smith, A. N., Choi, I., Lee, P., Sullivan, D. K., Burns, J. M., Swerdlow, R. H., Kelly, E., & Taylor, M. K.
Affiliations
  • Department of Dietetics &amp; Nutrition University of Kansas Medical Center, 3901 Rainbow Blvd. Kansas City Kansas USA
  • Department of Neurology University of Kansas Medical Center, 3901 Rainbow Blvd. Kansas City Kansas USA
Venue
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Publisher
Wiley
Published
2025-04
Volume
11
Issue
2
ISSN
2352-8737
DOI
10.1002/trc2.70101
Cited by
17
References
8
Language
en
Licence
creativecommons.org/licenses/by-nc/4.0/ (vor, 48 d)
Funders
  • Alzheimer's Association (AARG‐22‐924314)
  • National Institutes of Health (K01 AG065487, P30 AG072973)

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