Cited by 0Muscle metabolism and nutritionNutrition and Health in AgingBiochemical effects in animals

Effects of creatine supplementation with and without exercise and diet intervention on body composition, cognitive function, and markers of health in middle-aged and older adults

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Chun, Jisun, Liu, Yuhang, Kibler, Giuliet L., Lee, Hudson, Babakhani, Khatereh, Rhoades, Nathaniel, Bivins, Ian, Ko, Joungbo +5 more·2026·Journal of the International Society of Sports Nutrition

Abstract

BACKGROUND: Theoretically, CrM supplementation during a weight loss and exercise intervention may help older individuals promote more optimal changes in body composition, training adaptations, and cognition. To determine whether CrM affects body composition, cognitive function, and/or markers of health in untrained and trained middle-aged and older adults. METHODS: Seventy-three healthy sedentary adults selected whether to participate in a non-exercise or exercise and diet intervention and were then randomized, in a double-blind and counterbalanced manner, to 2 × 5 g/d of maltodextrin placebo (PLA) or CrM. Sixty-four adults aged 45-65 years (54.5 ± 6.2 years, 84.5 ± 21.3 kg; 40 females and 24 males) completed the 12-week intervention and were analyzed. At 0, 6, and 12 weeks, participants had DXA body composition determined, donated fasting blood samples, and completed a battery of cognitive tests and questionnaires. general linear models (GLMs), multivariate and univariate, with repeated measures and mean changes from baseline with 95% confidence intervals, and Chi-squared analyzes were used. RESULTS: CrM supplementation without exercise training and diet intervention increased lean tissue mass, strength, and muscular endurance while promoting favorable changes in selected blood lipids, HbA1c, and selected markers of cognitive function and memory. Creatine supplementation during an exercise and weight-loss diet intervention increased lean tissue mass, promoted a greater reduction in body fat percentage, and improved muscular strength, endurance, and selected markers of cognitive function and memory. Supplementation was well-tolerated. CONCLUSION: ISRCTN83081058.

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Authors
Chun, J., Liu, Y., Kibler, G. L., Lee, H., Babakhani, K., Rhoades, N., Bivins, I., Ko, J., Dickerson, B., Gonzalez, D. E., Sowinski, R. J., Rasmussen, C. J., & Kreider, R. B.
Affiliations
Texas A&M University (US)
Corresponding author
Kreider, Richard B.
Venue
Journal of the International Society of Sports Nutrition
Published
2026-08-11
Volume
23
Issue
sup1
Pages
2716273-2716273
ISSN
1550-2783 (ISSN-L)
OpenAlex
W7202183709
Cited by
0
References
155
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
  • Journal of the International Society of Sports Nutrition (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Woodnext Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Physiology › Biochemical effects in animals
Keywords
creatine supplementation, creatine monohydrate, body composition, lean body mass, fat-free mass, muscle strength, muscular endurance, cognitive function, memory, weight loss diet, exercise training, middle-aged and older adults, sedentary adults, serum lipids, HbA1c
MeSH terms
Cognitive Enhancement, Aged, Body Composition, Cognition, Creatine, Double-Blind Method, Female, Humans, Male, Middle Aged, Biomarkers, Exercise, Dietary Supplements, Muscle Strength

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