Cited by 31Congenital Anomalies and Fetal SurgeryPrenatal Screening and DiagnosticsFetal and Pediatric Neurological Disorders

Outcome of first-trimester fetal abdominal cysts: Cohort study and review of the literature

Khalil, A., Cooke, P. C., Mantovani, E., Bhide, A., Papageorghiou, A. T., Thilaganathan, B.·2014·Ultrasound in Obstetrics & Gynecology

Abstract

OBJECTIVES: The aims of this study were to ascertain the outcome of fetuses with an abdominal cyst detected at 11-14 weeks' gestation in our unit and to undertake a review of cases reported in the literature. METHODS: This was a retrospective study that included all fetuses found to have an abdominal cyst on ultrasound examination at 11-14 weeks, identified over a 14-year period. Pregnancy management and outcome were ascertained from maternal and neonatal records. We also performed a review of the literature using a systematic search strategy, to identify the outcome of similar cases and propose a management algorithm. RESULTS: Fourteen cases were identified during the study period, of which four had associated abnormalities. Of the 10 isolated cases, the cyst had resolved at follow-up scan in eight (80.0%), one fetus died in utero at 15 weeks' gestation and the other case underwent surgery for a choledochal cyst 9 weeks after birth. An additional 19 cases were reported in the literature. In eight fetuses there were associated structural abnormalities, of which four had a diagnosis of anorectal malformation after birth. In two of these four, the cyst resolved in the second trimester. Of those cases with an isolated cyst (n = 11), the cyst resolved in seven (63.6%). The remainder were variably diagnosed as hepatic cyst, ileal duplication or choledochal cyst. CONCLUSION: Fetal abdominal cysts at 11-14 weeks' gestation are rare. They constitute an isolated finding in the majority of cases and are usually associated with a good perinatal outcome. In view of the reported association with anorectal and other gastrointestinal malformations, perinatal assessment is recommended, even if the cyst resolves during pregnancy.

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Crossref · 10.1002/uog.12552

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  • While the majority of abdominal cysts resolved antenatally with no remaining consequences for the neonate, four cases with lower abdomen cysts were diagnosed with anorectal malformations postnatally.

    “Data from a cohort study showed that while the majority of cysts resolved antenatally, with no remaining consequences for the neonate, four cases with lower abdomen cysts were diagnosed with anorectal malformations postnatally [49].”

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Authors
Khalil, A., Cooke, P. C., Mantovani, E., Bhide, A., Papageorghiou, A. T., & Thilaganathan, B.
Affiliations
St George's, University of London (GB)
Corresponding author
Khalil, A.
Venue
Ultrasound in Obstetrics & Gynecology
Publisher
Wiley
Published
2014-04
Volume
43
Issue
4
Pages
413-419
ISSN
  • 0960-7692 (ISSN-L)
  • 1469-0705
OpenAlex
W1534023096
Cited by
30
References
40
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3
FWCI
0.29
Type
journal article
Language
en
Open access
closed
Locations
  • Ultrasound in Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Congenital Anomalies and Fetal Surgery
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
first-trimester ultrasound, anorectal malformation, choledochal cyst, liver cysts, ileal duplication, perinatal outcomes, pregnancy management, prenatal diagnosis
MeSH terms
Abdomen, Adult, Cysts, Female, Fetal Diseases, Humans, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Retrospective Studies, Cohort Studies, Ultrasonography, Prenatal, Treatment Outcome

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