Stress and placental resistance measured by doppler ultrasound in early and mid-pregnancy
Abstract
Objectives: To examine the association between self reports and biomarkers of stress and placental resistance (measured by Doppler ultrasound of the uterine and umbilical arteries), to determine if restriction of blood flow to the placenta is a mechanism by which stress might affect health during pregnancy. Methods: Eight hundred and seventy‐two women had ultrasound examinations of the uterine artery at 15–19 weeks' gestation and the uterine and umbilical arteries at 24–29 weeks, and resistance and pulsatility indices were calculated. Psychosocial stress was measured by telephone interview and self‐administered questionnaire using several validated tools twice during the pregnancy. Cortisol and corticotropin‐releasing hormone (CRH) were measured twice during the pregnancy. Linear and hierarchical models were used to examine the relationships among reported stress, stress hormones and placental Doppler indices. Results: The umbilical artery resistance index was higher in younger women, those with less education, those who were single and those who smoked. The uterine artery pulsatility index was higher in women with pre‐eclampsia, those living alone, those with high body mass index, and those who gained the least weight during pregnancy. A higher CRH level was associated with small increases in uterine artery pulsatility and umbilical artery resistance indices. Psychosocial measures of stress were not consistently associated with higher placental resistance. Conclusions: Increased CRH levels may be associated with increased placental resistance. Otherwise, these findings do not support the hypothesis that restriction of blood flow to the fetus is a major mechanism by which stress affects infant health. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.
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HPA hyperactivity may also contribute to overall preterm birth risk, as some studies link it to placental pathology such as preeclampsia, which raises risk for medically indicated preterm birth.
“HPA hyperactivity may also underlie overall risk for PTB, as some studies have identified a potential role in placental pathology (e.g., in preeclampsia; Harville et al., 2008; Petsas et al., 2012), which increases risk for medically-indicated PTB.”
From Childhood stress and birth timing among African American women: cortisol as biological mediator (2017) · cites this paper as Harville et al., 2008
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- Authors
- Harville, E. W., Savitz, D. A., Dole, N., Herring, A. H., Thorp, J. M., & Light, K. C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Harville, E. W.
- Venue
- Ultrasound in Obstetrics & Gynecology
- Publisher
- Wiley
- Published
- 2008-06-11
- Volume
- 32
- Issue
- 1
- Pages
- 23-30
- ISSN
- 0960-7692 (ISSN-L)
- 1469-0705
- OpenAlex
- W2061141128
- Cited by
- 41
- References
- 27
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ultrasound in Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Center for Research Resources (RR00046, M01RR000046)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD037584, HD39373, R01HD039373, HD 37584)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- psychosocial stress, placental resistance, uterine artery Doppler, umbilical artery Doppler, pulsatility index, resistance index, corticotropin-releasing factor, cortisol, preeclampsia, early pregnancy, second trimester, maternal smoking, body mass index, gestational weight gain, infant health
- MeSH terms
- Adult, Corticotropin-Releasing Hormone, Female, Humans, Hydrocortisone, North Carolina, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Saliva, Self Disclosure, Stress, Psychological, Umbilical Arteries, Uterus, Vascular Resistance, Ultrasonography, Prenatal, Ultrasonography, Doppler, Color, Ultrasonography, Doppler, Pulsed, Placental Circulation, Young Adult
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