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Cited by 924

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Overview of random forest methodology and practical guidance with emphasis on computational biology and bioinformatics

Open access
Boulesteix, Anne‐Laure, Janitza, Silke, Kruppa, Jochen, König, Inke R.·2012·WIREs Data Mining and Knowledge Discovery

Abstract

The random forest (RF) algorithm by Leo Breiman has become a standard data analysis tool in bioinformatics. It has shown excellent performance in settings where the number of variables is much larger than the number of observations, can cope with complex interaction structures as well as highly correlated variables and return measures of variable importance. This paper synthesizes 10 years of RF development with emphasis on applications to bioinformatics and computational biology. Special attention is paid to practical aspects such as the selection of parameters, available RF implementations, and important pitfalls and biases of RF and its variable importance measures (VIMs). The paper surveys recent developments of the methodology relevant to bioinformatics as well as some representative examples of RF applications in this context and possible directions for future research. © 2012 Wiley Periodicals, Inc. This article is categorized under: Algorithmic Development > Hierarchies and Trees Algorithmic Development > Statistics Application Areas > Health Care

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Metadata

Authors
Boulesteix, A., Janitza, S., Kruppa, J., & König, I. R.
Venue
WIREs Data Mining and Knowledge Discovery
Publisher
Wiley
Published
2012-10-18
Volume
2
Issue
6
Pages
493-507
ISSN
  • 1942-4787 (ISSN-L)
  • 1942-4795
OpenAlex
W1985372952
Cited by
924
References
5
FWCI
18.58
Type
journal article
Language
en
Open access
green

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