Clinical implications of co‐occurring prolonged grief disorder in patients with treatment‐resistant major depressive disorder
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Prolonged grief disorder worsens the severity of co-occurring conditions after bereavement, including PTSD and depression.
“Evidence is also emerging that prolonged grief disorder worsens the severity of co-occurring conditions after bereavement, including PTSD 86 and depression 87 .”
From Emerging experience with selected new categories in the <scp>ICD</scp>‐11: complex <scp>PTSD</scp>, prolonged grief disorder, gaming disorder, and compulsive sexual behaviour disorder (2022) · cites this paper as [87]
The results (pp. 303–304) show that bereaved patients with treatment-resistant depression and co-occurring PGD had more severe depression at baseline and were less likely to achieve remission. This supports the depression portion attributed to citation 87, but the observational comparison does not establish that PGD worsens depression, and the findings are limited to patients with treatment-resistant depression. PTSD is attached to a different citation in the citing sentence. (LLM, conf=0.84)
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Cites
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Grief and bereavement: what psychiatrists need to know
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Self-citationColumbia-Suicide Severity Rating Scale (C-SSRS)
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Optimizing Treatment of Complicated Grief: A Randomized Clinical Trial
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Reed, G. M., First, M. B., Billieux, J., Cloitre, M., Briken, P., Achab, S., Brewin, C. R., King, D. L., Kraus, S. W., & Bryant, R. A. (2022) · World Psychiatry · doi:10.1002/wps.20960 · Cited by 182 · see citing works
New research on validity and clinical utility of ICD‐11 vs. ICD‐10 and DSM‐5 diagnostic categories
Vincenzo, M. D. (2023) · World Psychiatry · doi:10.1002/wps.21053 · Cited by 9 · see citing works
Sampogna, G., Caraci, F., Carmassi, C., Dell’Osso, B. M., Ferrari, S., Martinotti, G., Sani, G., Serafini, G., Signorelli, M. S., & Fiorillo, A. (2023) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2023.2237410 · Cited by 6 · see citing works
Zisook, S., Johnson, G. R., Planeta, B. M., & Mohamed, S. (2025) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000002051 · Cited by 3 · see citing works
Self-citationEffect of next-step antidepressant treatment on suicidal ideation: findings from the VAST-D trial
Zisook, S., Moutier, C. Y., Rush, A. J., Johnson, G. R., Tal, I., Chen, P., Davis, L. L., Hicks, P. B., WILCOX, J. A., Planeta, B. M., et al. (2023) · Psychological Medicine · doi:10.1017/s0033291723003008 · Cited by 3 · see citing works
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Gibson, L. (2024) · OMEGA - Journal of Death and Dying · doi:10.1177/00302228241241098 · Cited by 2 · see citing works
Eco-anxiété, changement climatique et santé mentale
Heeren, A. (2024) · Carrefour des psychothérapies · doi:10.3917/dbu.heere.2024.01.0201
Keser, E., Soysal, G. C., & Prigerson, H. G. (2026) · Death Studies · doi:10.1080/07481187.2026.2676992
- Authors
- Zisook, S., Mohamad, S., Johnson, G., Tal, I., Villarreal, G., Wilcox, J. A., & Shear, K. M.
- Affiliations
- University of California San Diego (US)
- Yale University (US)
- VA Connecticut Healthcare System (US)
- VA San Diego Healthcare System (US)
- University of New Mexico (US)
- Southern Arizona VA Health Care System (US)
- Columbia University (US)
- Venue
- World Psychiatry
- Publisher
- Wiley
- Published
- 2021-05-18
- Volume
- 20
- Issue
- 2
- Pages
- 303-304
- ISSN
- 1723-8617 (ISSN-L)
- 2051-5545
- PMC
- PMC8129840
- OpenAlex
- W3162806011
- Cited by
- 9
- References
- 8
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- World Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Grief, Bereavement, and Mental Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- prolonged grief disorder, major depressive disorder, treatment-resistant depression, comorbidities, clinical implications
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