Cited by 358Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressFree Radicals and Antioxidants

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Kinetics and Mechanisms of Hypochlorous Acid Reactions

Folkes, Lisa K., Candeias, Luis P., Wardman, Peter·1995·Archives of Biochemistry and Biophysics

DOI 10.1006/abbi.1995.0017

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Abstract

Hypochlorous acid (HOCl) is a strong oxidant formed in neutrophils by the myeloperoxidase-catalyzed oxidation of chloride. Using stopped-flow with spectrophotometric detection, HOCl was found to react very rapidly with glutathione and ascorbate and less rapidly with taurine. No evidence could be found for the formation of reactive free-radical intermediates in these reactions, in support of an electrophilic mechanism. In contrast, the reaction with iron(II) aquo or citrate complexes (k approximately 10(4) dm3 mol-1 s-1 in acidic solution) yielded reactive intermediates distinguishable from hydroxyl radicals. The reaction between HOCl and ferrous ions, which is analogous to but faster than the Fenton reaction, is a potential source of free radicals in activated neutrophils.

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Authors: Folkes, L. K., Candeias, L. P., & Wardman, P.
Affiliations: Mount Vernon Hospital (GB)
ORCID: Wardman, Peter
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 1995-10
Volume: 323
Issue: 1
Pages: 120-126
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1006/abbi.1995.0017
OpenAlex: W1972880155
Cited by: 358
References: 0
Citations by year: 2026: 5 · 2025: 21 · 2024: 12 · 2023: 7 · 2022: 21 · 2021: 16 · 2020: 12 · 2019: 16 · 2018: 8 · 2017: 11 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 16 · 2012: 20
FWCI: 3.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords: hypochlorous acid, reaction kinetics, reaction mechanism, glutathione, vitamin C, taurine, iron(II) complexes, ferrous iron oxidation, Fenton reaction, hydroxyl radicals, radical intermediates, myeloperoxidase
MeSH terms: Ascorbic Acid, Free Radicals, Glutathione, Hypochlorous Acid, Kinetics, Taurine

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Kinetics and Mechanisms of Hypochlorous Acid Reactions

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