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Localization of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) during Human Embryonic Development: High Affinity Binding to Basement Membranes
Open accessAbstract
Osteogenic protein-1 (OP-1) is a member of the bone morphogenetic protein subfamily of the transforming growth factor-beta (TGF-beta) superfamily. Since members of the TGF-beta superfamily have a role in tissue development the distribution of OP-1 in developing human embryos (gestational age 5-14 weeks) was examined by immunohistochemical methods. Positive staining for OP-1 was observed in: sclerotome, hypertrophied chondrocytes, osteoblasts, periosteum, epithelial cells of the adrenal "provisional cortex" and the convoluted tubules of developing kidneys. In the developing lungs, pancreas and skin, OP-1 was localized in basement membranes underlying the epithelium. In vitro binding studies of 125I-OP-1 to various extracellular matrix components revealed high affinity of OP-1 for type IV collagen and less for heparin, collagen types I and VI. Present findings suggest that, in addition to bone formation, OP-1 could have other important regulatory roles in human embryogenesis with high binding affinity to a basement membrane component.
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Cited by
Luo, G., Hofmann, C., Bronckers, A. L., Sohocki, M., Bradley, A., & Karsenty, G. (1995) · Genes & Development · doi:10.1101/gad.9.22.2808 · Cited by 1,021
Yamaguchi, A., Komori, T., & Suda, T. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.4.0403 · Cited by 696
Sims, N. A., & Gooi, J. H. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.07.016 · Cited by 513
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Zeisberg, M., & Kalluri, R. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0517-9 · Cited by 507
Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme
Dudley, A. T., Godin, R. E., & Robertson, E. J. (1999) · Genes & Development · doi:10.1101/gad.13.12.1601 · Cited by 320
Metadata
- Authors
- Vukicevic, S., Latin, V., Chen, P., Batorsky, R., Reddi, A. H., & Sampath, T. K.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1994-01
- Volume
- 198
- Issue
- 2
- Pages
- 693-700
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2093135693
- Cited by
- 199
- References
- 0
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Localization of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) during Human Embryonic Development: High Affinity Binding to Basement Membranes. https://app.cochat.ai/papers/10.1006/bbrc.1994.1100
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- Vukicevic, S., Latin, V., Chen, P., Batorsky, R., Reddi, A. H., & Sampath, T. K. (1994). Localization of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) during Human Embryonic Development: High Affinity Binding to Basement Membranes. Biochemical and Biophysical Research Communications. https://doi.org/10.1006/bbrc.1994.1100
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
