Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

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Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

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Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

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Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

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Increased bone formation in osteocalcin-deficient mice

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RANK is essential for osteoclast and lymph node development.

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Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction

Kobayashi, K., Takahashi, N., Jimi, E., Udagawa, N., Takami, M., Kotake, S., Nakagawa, N., Kinosaki, M., Yamaguchi, K., Shima, N., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.2.275 · Cited by 1,304 · see citing works

Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesis<i>in Vitro</i>¹

Yasuda, H., Shima, N., Nakagawa, N., Mochizuki, S.-I., Yano, K., Fujise, N., Sato, Y., Goto, M., Yamaguchi, K., Kuriyama, M., et al. (1998) · Endocrinology · doi:10.1210/endo.139.3.5837 · Cited by 1,201 · see citing works

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199 · see citing works

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · see citing works

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

Winkler, D. G., Sutherland, M. K., Geoghegan, J. C., Yu, C., Hayes, T., Skonier, J. E., Shpektor, D., Jonas, M., Kovacevich, B. R., Staehling‐Hampton, K., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg599 · Cited by 1,114 · see citing works

Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone

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Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

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Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

van Bezooijen, R. L., Roelen, B. A. J., Visser, A., van der Wee-Pals, L. J. A., de Wilt, E., Karperien, M., Hamersma, H. A., Papapoulos, S. E., ten Dijke, P., & Löwik, C. W. G. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031454 · Cited by 893 · see citing works

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

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Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

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Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.

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Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777 · see citing works

Identification of a 52 kb deletion downstream of the <i>SOST</i> gene in patients with van Buchem disease

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Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) receptors.

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Osteoclast-derived activity in the coupling of bone formation to resorption

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Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis

Bellido, T., Ali, A., Gubrij, I. B., Plotkin, L. I., Fu, Q., O’Brien, C. A., Manolagas, S. C., & Jilka, R. L. (2005) · Endocrinology · doi:10.1210/en.2005-0239 · Cited by 640 · see citing works

SOST is a target gene for PTH in bone

Keller, H., & Kneissel, M. (2005) · Bone · doi:10.1016/j.bone.2005.03.018 · Cited by 618 · see citing works

Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells

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TRANCE, a TNF Family Member, Activates Akt/PKB through a Signaling Complex Involving TRAF6 and c-Src

Wong, B. R., Besser, D., Kim, N., Arron, J. R., Vologodskaia, M., Hanafusa, H., & Choi, Y. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80232-4 · Cited by 593 · see citing works

Increased intracortical remodeling following fatigue damage

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v-ATPase V0 subunit d2–deficient mice exhibit impaired osteoclast fusion and increased bone formation

Lee, S.-H., Rho, J., Jeong, D., Sul, J., Kim, T. S., Kim, N., Kang, J.-S., Miyamoto, T. K., Suda, T., Lee, S., et al. (2006) · Nature Medicine · doi:10.1038/nm1514 · Cited by 547 · see citing works

Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases

Guise, T. A., Mohammad, K. S., Clines, G. A., Stebbins, E. G., Wong, D. H., Higgins, L. S., Vessella, R. L., Corey, E., Padalecki, S. S., Suva, L. J., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1007 · Cited by 539 · see citing works

Bone Growth Factors

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Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

Suda, T. (1999) · Endocrine Reviews · doi:10.1210/er.20.3.345 · Cited by 485 · see citing works

IL-6, Leukemia Inhibitory Factor, and Oncostatin M Stimulate Bone Resorption and Regulate the Expression of Receptor Activator of NF-κB Ligand, Osteoprotegerin, and Receptor Activator of NF-κB in Mouse Calvariae

Palmqvist, P., Persson, E., Conaway, H. H., & Lerner, U. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3353 · Cited by 484 · see citing works

Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression.

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Osteotropic Agents Regulate the Expression of Osteoclast Differentiation Factor and Osteoprotegerin in Osteoblastic Stromal Cells

Horwood, N. J., Elliott, J., Martin, T. J., & Gillespie, M. T. (1998) · Endocrinology · doi:10.1210/endo.139.11.6433 · Cited by 456 · see citing works

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

Loots, G. G., Kneissel, M., Keller, H., Baptist, M., Chang, J., Collette, N. M., Ovcharenko, D., Plajzer-Frick, I., & Rubin, E. M. (2005) · Genome Research · doi:10.1101/gr.3437105 · Cited by 442 · see citing works

The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

Mócsai, A., Humphrey, M., Ziffle, J. V. V., Hu, Y., Burghardt, A., Spusta, S. C., Majumdar, S., Lanier, L., Lowell, C., & Nakamura, M. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401602101 · Cited by 436 · see citing works

Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment

Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E., & Orkin, S. H. (2007) · Cell · doi:10.1016/j.cell.2007.03.055 · Cited by 424 · see citing works

Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age

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The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation

Everts, V., Delaissé, J. M., Korper, W., Jansen, D. C., Tigchelaar-Gutter, W., Saftig, P., & Beertsen, W. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.77 · Cited by 411 · see citing works

Cancellous Bone Remodeling Occurs in Specialized Compartments Lined by Cells Expressing Osteoblastic Markers

Hauge, E. M., Qvesel, D., Eriksen, E. F., Mosekilde, L., & Melsen, F. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1575 · Cited by 397 · see citing works

Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone

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Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading

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RANKL-induced DC-STAMP Is Essential for Osteoclastogenesis

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Osteoprogenitor response to defined topographies with nanoscale depths

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αvβ3and macrophage colony‐stimulating factor: partners in osteoclast biology

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Introduction to bone biology

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Model structure and control of bone remodeling: A theoretical study

Pivonka, P., Zimak, J., Smith, D. W., Gardiner, B. S., Dunstan, C. R., Sims, N. A., Martin, T. J., & Mundy, G. R. (2008) · Bone · doi:10.1016/j.bone.2008.03.025 · Cited by 299 · see citing works

A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy

Kamioka, H., Honjo, T., & Takano‐Yamamoto, T. (2001) · Bone · doi:10.1016/s8756-3282(00)00421-x · Cited by 287 · see citing works

Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation

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Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34

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Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis

Malaval, L., Wade‐Gueye, N. M., Boudiffa, M., Fei, J., Zirngibl, R. A., Chen, F., Laroche, N., Roux, J.-P., Burt‐Pichat, B., Duboeuf, F., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071294 · Cited by 275 · see citing works

Recruitment of osteoclast precursors by purified bone matrix constituents.

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Haploinsufficiency of Parathyroid Hormone-Related Peptide (PTHrP) Results in Abnormal Postnatal Bone Development

Amizuka, N., Karaplis, A. C., Henderson, J. E., Warshawsky, H., Lipman, M. L., Matsuki, Y., Ejiri, S., Tanaka, M. W., Izumi, N., Ozawa, H., et al. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0104 · Cited by 253 · see citing works

Cell–cell communication in the osteoblast/osteocyte lineage

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Osteopontin Deficiency Produces Osteoclast Dysfunction Due to Reduced CD44 Surface Expression

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Stromal Cell-Derived Factor-1 (SDF-1) Recruits Osteoclast Precursors by Inducing Chemotaxis, Matrix Metalloproteinase-9 (MMP-9) Activity, and Collagen Transmigration

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Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation

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Bone cells predispose bone surfaces to resorption by exposure of mineral to osteoclastic contact

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Regulation of bone remodeling by the central and peripheral nervous system

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Dissociation between bone resorption and bone formation in osteopenic transgenic mice

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Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice

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Apoptotic Bodies Convey Activity Capable of Initiating Osteoclastogenesis and Localized Bone Destruction

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CCR1 Chemokines Promote the Chemotactic Recruitment, RANKL Development, and Motility of Osteoclasts and Are Induced by Inflammatory Cytokines in Osteoblasts

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Transforming growth factor-beta and remodeling of bone.

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Mammalian collagenase predisposes bone surfaces to osteoclastic resorption

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EphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts

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Localization of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) during Human Embryonic Development: High Affinity Binding to Basement Membranes

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Spatial Distribution of Bax and Bcl-2 in Osteocytes After Bone Fatigue: Complementary Roles in Bone Remodeling Regulation?

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Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

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Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: implications for diagnosis and treatment

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Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia

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Interleukin‐11 Receptor Signaling Is Required for Normal Bone Remodeling

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The Bone Remodeling Compartment: A Circulatory Function for Bone Lining Cells

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Linkage of M-CSF Signaling to Mitf, TFE3, and the Osteoclast Defect in Mitfmi/mi Mice

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Remodeling and Vascular Spaces in Bone

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Is All Bone the Same? Distinctive Distributions and Properties of Non-Collagenous Matrix Proteins in Lamellar Vs. Woven Bone Imply the Existence of Different Underlying Osteogenic Mechanisms

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The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function

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Expression of bone morphogenetic protein messenger RNAs by normal rat and human prostate and prostate cancer cells

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Mechanical stimulation in vivo reduces osteocyte expression of sclerostin.

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Chemokines in multiple myeloma

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