Distinct Patterns of Cyclin D1 Regulation in Models of Liver Regeneration and Human Liver
Abstract
The expression of cyclin D1 and associated cdks was examined in models of liver regeneration and human liver specimens. In mouse liver after 70% partial hepatectomy, there was > 20-fold induction of cyclin D1 mRNA and protein, beginning prior to peak DNA synthesis. In normal rat liver, basal levels of cyclin D1 protein were significantly higher than in the mouse. After hepatectomy in the rat, cyclin D1 mRNA was induced 6- to 10-fold, while the protein levels changed 20-fold in rat hepatocytes. Immunoprecipitation of cyclin D1 demonstrated its association with cdk4 but not cdk5 in regenerating liver. In human liver biopsy specimens, cyclin D1 protein was detectable in normal liver and induced 2- to 10-fold in mitotically active liver following transplantation. These results suggest that the regulation of cyclin D1 protein in human liver may more closely parallel the mouse than the rat hepatectomy model. Furthermore, cyclin expression in primary cells in culture may differ significantly from that observed in vivo.
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Cyclin D1 is up-regulated during liver regeneration after partial hepatectomy.
“Cyclin D1 is up-regulated during liver regeneration after PH, 7,28,29”
From Interleukin 6 Is Important for Survival After Partial Hepatectomy in Mice (2003) · cites this paper as [28]
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- Authors
- Albrecht, J. H., Hu, M. Y., & Cerra, F. B.
- Affiliations
- University of Minnesota (US)
- ORCID
- Albrecht, J.H.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 209
- Issue
- 2
- Pages
- 648-655
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2043906334
- Cited by
- 95
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 4
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- cyclin D1, liver regeneration, partial hepatectomy, cyclin-dependent kinases, CDK4, cyclin-dependent kinase 5, hepatocytes, hepatocyte growth factor, species differences, cell cycle regulation
- MeSH terms
- Animals, Cells, Cultured, Hepatectomy, Humans, Liver Regeneration, Proto-Oncogene Proteins, RNA, Messenger, Time Factors, Oncogene Proteins, Gene Expression, Cyclins, Protein Serine-Threonine Kinases, Cyclin-Dependent Kinases, Cyclin D1, Cyclin-Dependent Kinase 4, Mice, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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