Nitric oxide (nitrogen monoxide, NO) stimulates insulin secretion by inducing calcium release from mitochondria
Abstract
Nitric oxide (nitrogen monoxide, NO) acts as messenger molecule in a variety of cells and may also be involved in the insulin secretory pathway of islet beta-cells. We report here that NO at a low micromolar concentration stimulates epinephrine-sensitive insulin secretion from cells of the beta-cell line, INS-1. Insulin secretion is paralleled by a reversible decrease of the mitochondrial membrane potential and by an increase of the cytosolic calcium. Chelation of intracellular, but not of extracellular calcium prevents the NO-induced insulin secretion. These data indicate that NO can stimulate insulin secretion by deenergizing mitochondria and thereby triggering mitochondrial calcium release.
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Insulin resistance is improved by NO at various levels including insulin secretion, mitochondrial function, modulation of inflammation, insulin signaling, and glucose uptake.
“Insulin resistance is improved by NO at various levels including insulin secretion [54,55], mitochondrial function [56], modulation of inflammation [57], insulin signaling [58] and glucose uptake [59].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [54]
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- Authors
- Laffranchi, R., Gogvadze, V., Richter, C., & Spinas, G. A.
- Affiliations
- University of Zurich (CH)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 217
- Issue
- 2
- Pages
- 584-591
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2066215218
- Cited by
- 87
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2015: 2 · 2014: 4 · 2012: 2
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- nitric oxide, insulin secretion, pancreatic beta cells, mitochondrial calcium release, mitochondrial membrane potential, intracellular calcium, epinephrine, INS-1 cells, calcium chelation
- MeSH terms
- Insulin Secretion, Animals, Calcium, Carbonyl Cyanide m-Chlorophenyl Hydrazone, Cell Line, Epinephrine, Insulin, Intracellular Membranes, Islets of Langerhans, Membrane Potentials, Mitochondria, Nitric Oxide, Secretory Rate, Uncoupling Agents, Signal Transduction, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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