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Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation
Open accessAbstract
Amyloid beta-peptide (A beta) is a major fibrillar component of neuritic plaques in Alzheimer's disease (AD) brains and is related to the pathogenesis of the disease. We hypothesized that amyloid formation could be inhibited by peptides homologous to A beta (position 17-21) with a similar degree of hydrophobicity, but with a very low propensity to adopt a beta-sheet conformation by incorporating proline residues (anti-beta-sheet peptides or beta-sheet inhibitors). An 11-residue peptide with these characteristics binds to A beta, inhibits A beta fibril formation and partially disaggregates preformed fibrils in vitro. Shorter anti-beta-sheet peptides and analogs containing D-amino acids are also able to inhibit A beta fibrillogenesis. The latter are more resistant to proteolytic degradation and may serve as a starting point to design more efficient peptides derivatives to inhibit amyloidogenesis in vivo.
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Cited by
Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y.-S., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00317-8 · Cited by 1,447
Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro
Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20025 · Cited by 1,254
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
Nilsberth, C., Westlind-Danielsson, A., Eckman, C. B., Condron, M. M., Axelman, K., Forsell, C., Stenh, C., Luthman, J., Teplow, D. B., Younkin, S. G., et al. (2001) · Nature Neuroscience · doi:10.1038/nn0901-887 · Cited by 1,209
Ono, K., & Yamada, M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03707.x · Cited by 320
Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides
Soto, C., Kascsak, R. J., Saborío, G. P., Aucouturier, P., Wisniewski, T., Prelli, F., Kascsak, R., Mendez, E., Harris, D. A., Ironside, J., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(99)11419-3 · Cited by 274
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Metadata
- Authors
- Soto, C., Kindy, M. S., Baumann, M., & Frangione, B.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 226
- Issue
- 3
- Pages
- 672-680
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2092662963
- Cited by
- 431
- References
- 0
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation. https://app.cochat.ai/papers/10.1006/bbrc.1996.1413
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- Soto, C., Kindy, M. S., Baumann, M., & Frangione, B. (1996). Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation. Biochemical and Biophysical Research Communications. https://doi.org/10.1006/bbrc.1996.1413
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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