Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro
Abstract
Inhibition of the accumulation of amyloid beta-peptide (Abeta) and the formation of beta-amyloid fibrils (fAbeta) from Abeta, as well as the destabilization of preformed fAbeta in the central nervous system, would be attractive therapeutic targets for the treatment of Alzheimer's disease (AD). We reported previously that nordihydroguaiaretic acid (NDGA) and wine-related polyphenols inhibit fAbeta formation from Abeta(1-40) and Abeta(1-42) and destabilize preformed fAbeta(1-40) and fAbeta(1-42) dose-dependently in vitro. Using fluorescence spectroscopic analysis with thioflavin T and electron microscopic studies, we examined the effects of curcumin (Cur) and rosmarinic acid (RA) on the formation, extension, and destabilization of fAbeta(1-40) and fAbeta(1-42) at pH 7.5 at 37 degrees C in vitro. We next compared the anti-amyloidogenic activities of Cur and RA with NDGA. Cur and RA dose-dependently inhibited fAbeta formation from Abeta(1-40) and Abeta(1-42), as well as their extension. In addition, they dose-dependently destabilized preformed fAbetas. The overall activities of Cur, RA, and NDGA were similar. The effective concentrations (EC(50)) of Cur, RA, and NDGA for the formation, extension, and destabilization of fAbetas were in the order of 0.1-1 microM. Although the mechanism by which Cur and RA inhibit fAbeta formation from Abeta and destabilize preformed fAbeta in vitro remains unclear, they could be a key molecule for the development of therapeutics for AD.
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Oral curcumin inhibits amyloid beta peptide oligomerization and deposition in the brain in Alzheimer's disease animal models.
“The curcumin oral administration in Alzheimer’s disease animal models determines the inhibition of Amiloid beta (Aβ) peptide oligomerization and deposition in the brain [56].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [56]
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Lobine, D., Sadeer, N., Jugreet, S., Suroowan, S., Keenoo, B. S., Imran, M., Venugopala, K. N., Ibrahim, F. M., Zengin, G., & Mahomoodally, M. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210412095251 · Cited by 32 · see citing works
- Authors
- Ono, K., Hasegawa, K., Naiki, H., & Yamada, M.
- Affiliations
- Kanazawa University (JP)
- University of Fukui (JP)
- Corresponding author
- Yamada, Masahito
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2004-02-13
- Volume
- 75
- Issue
- 6
- Pages
- 742-750
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2048695741
- Cited by
- 1,254
- References
- 58
- Citations by year
- 2026: 18 · 2025: 35 · 2024: 40 · 2023: 48 · 2022: 53 · 2021: 58 · 2020: 66 · 2019: 67 · 2018: 61 · 2017: 64 · 2016: 57 · 2015: 64 · 2014: 60 · 2013: 62 · 2012: 65
- FWCI
- 34.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, rosmarinic acid, nordihydroguaiaretic acid, amyloid-beta, amyloid-beta fibrils, anti-amyloidogenic activity, Alzheimer's disease, fibril destabilization, Aβ(1-40), amyloid-beta 42, thioflavin T
- MeSH terms
- Rosmarinic Acid, Alzheimer Disease, Anti-Inflammatory Agents, Non-Steroidal, Cinnamates, Curcumin, Dose-Response Relationship, Drug, Kinetics, Microscopy, Electron, Microscopy, Polarization, Masoprocol, Peptide Fragments, Platelet Aggregation Inhibitors, Spectrometry, Fluorescence, Thiazoles, Time Factors, Amyloid beta-Peptides, Lipoxygenase Inhibitors, Neurofibrillary Tangles, Benzothiazoles, Depsides, In Vitro Techniques
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