Cited by 1,254Alzheimer's disease research and treatmentsCurcumin's Biomedical ApplicationsMedicinal Plants and Neuroprotection

Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

Ono, Kenjiro, Hasegawa, Kazuhiro, Naiki, Hironobu, Yamada, Masahito·2004·Journal of Neuroscience Research

Abstract

Inhibition of the accumulation of amyloid beta-peptide (Abeta) and the formation of beta-amyloid fibrils (fAbeta) from Abeta, as well as the destabilization of preformed fAbeta in the central nervous system, would be attractive therapeutic targets for the treatment of Alzheimer's disease (AD). We reported previously that nordihydroguaiaretic acid (NDGA) and wine-related polyphenols inhibit fAbeta formation from Abeta(1-40) and Abeta(1-42) and destabilize preformed fAbeta(1-40) and fAbeta(1-42) dose-dependently in vitro. Using fluorescence spectroscopic analysis with thioflavin T and electron microscopic studies, we examined the effects of curcumin (Cur) and rosmarinic acid (RA) on the formation, extension, and destabilization of fAbeta(1-40) and fAbeta(1-42) at pH 7.5 at 37 degrees C in vitro. We next compared the anti-amyloidogenic activities of Cur and RA with NDGA. Cur and RA dose-dependently inhibited fAbeta formation from Abeta(1-40) and Abeta(1-42), as well as their extension. In addition, they dose-dependently destabilized preformed fAbetas. The overall activities of Cur, RA, and NDGA were similar. The effective concentrations (EC(50)) of Cur, RA, and NDGA for the formation, extension, and destabilization of fAbetas were in the order of 0.1-1 microM. Although the mechanism by which Cur and RA inhibit fAbeta formation from Abeta and destabilize preformed fAbeta in vitro remains unclear, they could be a key molecule for the development of therapeutics for AD.

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Crossref · 10.1002/jnr.20025

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  • Oral curcumin inhibits amyloid beta peptide oligomerization and deposition in the brain in Alzheimer's disease animal models.

    “The curcumin oral administration in Alzheimer’s disease animal models determines the inhibition of Amiloid beta (Aβ) peptide oligomerization and deposition in the brain [56].”

    From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [56]

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Authors
Ono, K., Hasegawa, K., Naiki, H., & Yamada, M.
Affiliations
  • Kanazawa University (JP)
  • University of Fukui (JP)
Corresponding author
Yamada, Masahito
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
2004-02-13
Volume
75
Issue
6
Pages
742-750
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
OpenAlex
W2048695741
Cited by
1,254
References
58
Citations by year
2026: 18 · 2025: 35 · 2024: 40 · 2023: 48 · 2022: 53 · 2021: 58 · 2020: 66 · 2019: 67 · 2018: 61 · 2017: 64 · 2016: 57 · 2015: 64 · 2014: 60 · 2013: 62 · 2012: 65
FWCI
34.83
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
curcumin, rosmarinic acid, nordihydroguaiaretic acid, amyloid-beta, amyloid-beta fibrils, anti-amyloidogenic activity, Alzheimer's disease, fibril destabilization, Aβ(1-40), amyloid-beta 42, thioflavin T
MeSH terms
Rosmarinic Acid, Alzheimer Disease, Anti-Inflammatory Agents, Non-Steroidal, Cinnamates, Curcumin, Dose-Response Relationship, Drug, Kinetics, Microscopy, Electron, Microscopy, Polarization, Masoprocol, Peptide Fragments, Platelet Aggregation Inhibitors, Spectrometry, Fluorescence, Thiazoles, Time Factors, Amyloid beta-Peptides, Lipoxygenase Inhibitors, Neurofibrillary Tangles, Benzothiazoles, Depsides, In Vitro Techniques

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