Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology
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Cerebrospinal fluid tau (CSF-tau) levels were quantified in 8 patients with frontotemporal dementia (FTD), 6 patients with progressive supranuclear palsy (PSP), 3 patients with corticobasal degeneration (CBD), and 6 patients with dementia with Lewy bodies (DLB). The CSF-tau levels were significantly increased in FTD and DLB, but not in PSP and CBD, compared to that previously reported in normal controls. Notably, the CSF-tau level in DLB was as high as that in Alzheimer's disease (AD). Our study suggests that tau may accumulate in the CSF of patients with certain neurodegenerative diseases other than AD and that measurement of CSF-tau may not distinguish AD from DLB.
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Elevated CSF T-tau level is not specific to AD as it may also be elevated in other neurodegenerative diseases.
“However, clinical studies have shown that the elevated CSF T-tau level is not specific to AD as it may also be elevated in other neurodegenerative diseases (Arai et al., 1997; Urakami et al., 2001).”
From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Arai et al., 1997
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Research works printed but not linked: 2
- Trojanowski, J. Q., Clark, C. M., Arai, H., and Lee, V. M-Y. Neuropathol. 3, 185-192. (1996) Alzheimer's disease Review 1, 77-83.
- Saitoh, T., Xia, Y., Chen, X., Masliah, E., Galasko, D., Shults, C., Thal, L. J., Hansen, L. A., and Katzman, R. (1995) Ann. Neu- ogy, (Appel, S., Ed.), Vol. 16, pp. 93-113, Mosby Year Book, New York. rol. 37, 110-112.
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- Authors
- Arai, H., Morikawa, Y.-I., Higuchi, M., Matsui, T., Clark, C. M., Miura, M., Machida, N., Lee, V. M.-Y., Trojanowski, J. Q., & Sasaki, H.
- Affiliations
- Tohoku University (JP)
- University of Pennsylvania (US)
- Mitsubishi Group (Japan) (JP)
- Corresponding author
- Arai, Hiroyuki
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 236
- Issue
- 2
- Pages
- 262-264
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2094261122
- Cited by
- 159
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 9
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebrospinal fluid tau, tau protein, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies, Alzheimer's disease, neurodegenerative diseases, differential diagnosis, biomarkers
- MeSH terms
- Aged, Alzheimer Disease, Dementia, Humans, Middle Aged, Nerve Degeneration, Supranuclear Palsy, Progressive, tau Proteins
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