The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Gene Structure for Mouse Glutathione Reductase, Including a Putative Mitochondrial Targeting Signal
Abstract
Glutathione reductase (GR) is an important component of cellular antioxidant defense functions. Although GR activities are found in mitochondria and cytoplasm, the sorting mechanisms of mammalian GR into mitochondria have not been elucidated. To identify the mouse GR gene structure, including a sequence for a potential mitochondrial targeting signal (MTS), we screened a mouse genomic library and isolated four contiguous clones that covered the entire coding region of the gene. The coding region is composed of 13 exons. Exon 1 has two in-frame start codons separated by a sequence for an arginine-rich peptide segment. Expression studies, in which Chinese hamster ovary cells were transiently transfected with a plasmid containing the first 78 bp of the mouse exon 1 attached 5' to the human GR cDNA, showed marked and selective increases in mitochondrial GR activities. The data indicate that this 78 bp sequence encodes a potential MTS for GR in mice.
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“and by enzyme-mediated reduction of GSSG by mitochondrially targeted GR (414)”
From Redox regulation of mitochondrial function (2012) · cites this paper as [414]
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Redox regulation of mitochondrial function
Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588
Metadata
- Authors
- Tamura, T., McMicken, H. W., Smith, C. V., & Hansen, T. N.
- Affiliations
- Baylor College of Medicine (US)
- The Ohio State University (US)
- ORCID
- Tamura, Toshiya
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 237
- Issue
- 2
- Pages
- 419-422
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1997811320
- Cited by
- 26
- References
- 13
- Citations by year
- 2026: 1 · 2016: 1 · 2014: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM044263, GM-44263)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24823)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Keywords
- glutathione reductase, mitochondrial targeting signal, gene structure, exon-intron organization, arginine-rich peptides, antioxidant defense
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Exons, Glutathione Reductase, Cricetinae, Humans, Introns, Molecular Sequence Data, Recombinant Proteins, CHO Cells, Sequence Homology, Amino Acid, DNA, Complementary, Protein Sorting Signals, Mice
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