CoChat
Sign Up
Cited by 26Redox biology and oxidative stressGlutathione Transferases and PolymorphismsSelenium in Biological Systems

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Gene Structure for Mouse Glutathione Reductase, Including a Putative Mitochondrial Targeting Signal

Tamura, Toshiya, McMicken, Harilyn W., Smith, Charles V., Hansen, Thomas N.·1997·Biochemical and Biophysical Research Communications
DOI 10.1006/bbrc.1997.7153
Open this paper in CoChat — free account

Abstract

Glutathione reductase (GR) is an important component of cellular antioxidant defense functions. Although GR activities are found in mitochondria and cytoplasm, the sorting mechanisms of mammalian GR into mitochondria have not been elucidated. To identify the mouse GR gene structure, including a sequence for a potential mitochondrial targeting signal (MTS), we screened a mouse genomic library and isolated four contiguous clones that covered the entire coding region of the gene. The coding region is composed of 13 exons. Exon 1 has two in-frame start codons separated by a sequence for an arginine-rich peptide segment. Expression studies, in which Chinese hamster ovary cells were transiently transfected with a plasmid containing the first 78 bp of the mouse exon 1 attached 5' to the human GR cDNA, showed marked and selective increases in mitochondrial GR activities. The data indicate that this 78 bp sequence encodes a potential MTS for GR in mice.

Overview

Integrity signals

Registry

Crossref · 10.1006/bbrc.1997.7153

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Creissen, 1992, Plant J., 2, 129, 10.1046/j.1365-313X.1992.t01-52-00999.x · DOI

Cited by

Sorted by citations

See all 26

Related

See all

Metadata

Authors
Tamura, T., McMicken, H. W., Smith, C. V., & Hansen, T. N.
Affiliations
  • Baylor College of Medicine (US)
  • The Ohio State University (US)
ORCID
Tamura, Toshiya
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1997-08
Volume
237
Issue
2
Pages
419-422
ISSN
0006-291X (ISSN-L)
DOI
10.1006/bbrc.1997.7153
OpenAlex
W1997811320
Cited by
26
References
13
Citations by year
2026: 1 · 2016: 1 · 2014: 1
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (R01GM044263, GM-44263)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24823)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Keywords
glutathione reductase, mitochondrial targeting signal, gene structure, exon-intron organization, arginine-rich peptides, antioxidant defense
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, Exons, Glutathione Reductase, Cricetinae, Humans, Introns, Molecular Sequence Data, Recombinant Proteins, CHO Cells, Sequence Homology, Amino Acid, DNA, Complementary, Protein Sorting Signals, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review