Notochord Patterning of the Endoderm
Open accessAbstract
Endodermally derived organs of the gastrointestinal and respiratory system form at distinct anterioposterior and dorsoventral locations along the vertebrate body axis. This stereotyped program of organ formation depends on the correct patterning of the endodermal epithelium so that organ differentiation and morphogenesis occur at appropriate positions along the gut tube. Whereas some initial patterning of the endoderm is known to occur early, during germ-layer formation and gastrulation, later signaling events, originating from a number of adjacent tissue layers, are essential for the development of endodermal organs. Previous studies have shown that signals arising from the notochord are important for patterning of the ectodermally derived floor plate of the neural tube and the mesodermally derived somites. This review will discuss recent evidence indicating that signals arising from the notochord also play a role in regulating endoderm development.
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FGF2 and Activin, secreted by the notochord, lead to expression of pancreatic markers by repressing Shh in pancreatic endoderm.
“FGF2 and Activin, secreted by the notochord, lead to the expression of pancreatic markers by repressing expression of Shh in pancreatic endoderm [15-19].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [19]
In “Notochord Signals Are Required for Pancreas Development,” the paper says activin-βB and FGF2 mimicked notochord signaling in vitro by inhibiting SHH expression and allowing pancreatic marker expression. “Possible Nature of Notochord Signals” describes them as implicated signals, but the copy does not establish that both are secreted by the notochord. The claim states that point more definitively than the source does. (LLM, conf=0.86)
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Cites
Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759 · see citing works
Notochord to endoderm signaling is required for pancreas development
Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development · doi:10.1242/dev.124.21.4243 · Cited by 405 · see citing works
Halpern, M. E., Thisse, C., Ho, R. K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E. S., Postlethwait, J. H., & Kimmel, C. B. (1995) · Development · doi:10.1242/dev.121.12.4257 · Cited by 178 · see citing works
Axial Mesoderm and Patterning of the Zebrafish Embryo
HALPERN, M. E. (1997) · American Zoologist · doi:10.1093/icb/37.3.311 · Cited by 15 · see citing works
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Research works printed but not linked: 11
- Dawes, B. (1930). The development of the vertebral column in mammals, as illustrated by its development in Mus musculus. Philos. Trans. R. Soc. London B 218, 115-170.
- Eyal-Giladi, H. (1958). The notochord as inductor of the orohy- pophysis in urodeles (Pleurodeles waltii). Proc. K. Med. Wet. (Amsterdam) 61, 224 -234.
- Froriep, A. (1882). Kopfteil der Chorda dorsalis bei menschlichen Embryonen. In "Beitra ¨ge zur Anatomie und Embryologie als Festgabe fu ¨r Jacob Henle, Dargeboten von Seinen Schu ¨lern," pp. 26 -40. Bonn.
- Gradwohl, G., Dierich, A., LeMeur, M., and Guillemot, F. (2000). neurogenin3 is required for the development of the four endo- crine cell lineages of the pancreas. Proc. Natl. Acad. Sci. USA 97, 1607-1611.
- Kim, S. K., and Melton, D. A. (1998). Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. USA 95, 13036 -13041.
- Pourquie, O., Coltey, M., Teillet, M. A., Ordahl, C., and Le Douarin, N. M. (1993). Control of dorsoventral patterning of somitic derivatives by notochord and floor plate. Proc. Natl. Acad. Sci. USA 90, 5242-5246.
- Rudnick, A., Ling, T. Y., Odagiri, H., Rutter, W. J., and German, M. S. (1994). Pancreatic beta cells express a diverse set of homeobox genes. Proc. Natl. Acad. Sci. USA 91, 12203-12207.
- Spemann, H. (1938). "Embryonic Development and Induction." Yale Univ. Press, New Haven, CT.
- Teillet, M. A., Lapointe, F., and Le Douarin, N. M. (1998). The relationships between notochord and floor plate in vertebrate de- velopment revisited. Proc. Natl. Acad. Sci. USA 95, 11733-11738.
- van Straaten, H. W., and Drukker, J. (1987). In "Mesenchymal- Epithelial Interactions in Neural Development" (J. R. Woolf et al., Eds.), pp. 153-162. Springer-Verlag, Berlin.
- Wessels, N. K. (1977). Tissue interactions and cell differentiation. In "Tissue Interactions in Development," pp. 105-121.
Cited by
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Endothelial cells and VEGF in vascular development
Coultas, L., Chawengsaksophak, K., & Rossant, J. (2005) · Nature · doi:10.1038/nature04479 · Cited by 1,016 · see citing works
Hou, J., Charters, A. M., Lee, S. C., Zhao, Y., Wu, M. K., Jones, S. J., Marra, M. A., & Hoodless, P. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-92 · Cited by 56 · see citing works
“FGF2 and Activin, secreted by the notochord, lead to the expression of pancreatic markers by repressing expression of Shh in pancreatic endoderm [15-19].”
Background
- Authors
- Cleaver, O., & Krieg, P. A.
- Affiliations
- Harvard University (US)
- University of Arizona (US)
- Corresponding author
- Krieg, Paul A
- ORCID
- Cleaver, Ondine
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 234
- Issue
- 1
- Pages
- 1-12
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1984953267
- Cited by
- 114
- References
- 4
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 6
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- National Institutes of Health (HL63926)
- National Heart, Lung, and Blood Institute (P01HL063926, HL74763, HL63926)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Renal and related cancers
- Keywords
- notochord, endoderm patterning, dorsoventral patterning, signaling, floor plate, somites, neural tube, digestive system, respiratory system, organ morphogenesis
- MeSH terms
- Ectoderm, Embryonic Induction, Endoderm, Germ Layers, Mesoderm, Notochord, Pancreas, Body Patterning
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