Notochord to endoderm signaling is required for pancreas development
Abstract
The role of the notochord in inducing and patterning adjacent neural and mesodermal tissues is well established. We provide evidence that the notochord is also required for one of the earliest known steps in the development of the pancreas, an endodermally derived organ. At a developmental stage in chick embryos when the notochord touches the endoderm, removal of notochord eliminates subsequent expression of several markers of dorsal pancreas bud development, including insulin, glucagon and carboxypeptidase A. Pancreatic gene expression can be initiated and maintained in prepancreatic chick endoderm grown in vitro with notochord. Non-pancreatic endoderm, however, does not express pancreatic genes when recombined with the same notochord. The results suggest that the notochord provides a permissive signal to endoderm to specify pan-creatic fate in a stepwise manner.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
FGF2 and Activin, secreted by the notochord, lead to expression of pancreatic markers by repressing Shh in pancreatic endoderm.
“FGF2 and Activin, secreted by the notochord, lead to the expression of pancreatic markers by repressing expression of Shh in pancreatic endoderm [15-19].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [18]
Cites
A series of normal stages in the development of the chick embryo
Hamburger, V., & Hamilton, H. L. (1951) · Journal of Morphology · doi:10.1002/jmor.1050880104 · Cited by 12,254 · see citing works
Sonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. J. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,285 · see citing works
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154 · see citing works
Insulin-promoter-factor 1 is required for pancreas development in mice
Jonsson, J., Carlsson, L., Edlund, T., & Edlund, H. (1994) · Nature · doi:10.1038/371606a0 · Cited by 1,879 · see citing works
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. M., & Wright, C. V. E. (1996) · Development · doi:10.1242/dev.122.3.983 · Cited by 1,514 · see citing works
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
Liem, K. F., Tremml, G., Roelink, H., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90276-7 · Cited by 1,071 · see citing works
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Brenner‐Morton, S., Baldassare, M., Edlund, H., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 997 · see citing works
Developmental biology of the pancreas
Slack, J. M. W. (1995) · Development · doi:10.1242/dev.121.6.1569 · Cited by 947 · see citing works
IPF1, a homeodomain‐containing transactivator of the insulin gene.
Ohlsson, H., Karlsson, K., & Edlund, H. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06109.x · Cited by 893 · see citing works
Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V. P., Norlin, S., Altaba, A. R. I., Tanabe, Y., Placzek, M., Edlund, H., Jessell, T. M., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90514-2 · Cited by 854 · see citing works
Yamada, T., Placzek, M., Tanaka, H., Dodd, J., & Jessell, T. M. (1991) · Cell · doi:10.1016/0092-8674(91)90247-v · Cited by 707 · see citing works
Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
Ahlgren, U., Pfaff, S. L., Jessell, T. M., Edlund, H., & Edlund, H. (1997) · Nature · doi:10.1038/385257a0 · Cited by 688 · see citing works
Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene <i>Islet-1</i>
Ericson, J., Thor, S., Edlund, T., Jessell, T. M., & Yamada, T. (1992) · Science · doi:10.1126/science.1350865 · Cited by 620 · see citing works
Ahlgren, U., Jonsson, J., & Edlund, H. (1996) · Development · doi:10.1242/dev.122.5.1409 · Cited by 547 · see citing works
An ultrastructural analysis of the developing embryonic pancreas
PICTET, R. L., Clark, W. R., Williams, R. H., & Rutter, W. J. (1972) · Developmental Biology · doi:10.1016/0012-1606(72)90083-8 · Cited by 507 · see citing works
Martı́, E., Bumcrot, D. A., Takada, R., & McMahon, A. P. (1995) · Nature · doi:10.1038/375322a0 · Cited by 491 · see citing works
Lyons, K. M., Hogan, B. L. M., & Robertson, E. J. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00326-i · Cited by 427 · see citing works
Epitheliomesenchymal interaction in pancreatic morphogenesis
Golosow, N., & Grobstein, C. (1962) · Developmental Biology · doi:10.1016/0012-1606(62)90042-8 · Cited by 401 · see citing works
Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs
Valenzuela, P., Quiroga, M., Zaldivar, J., Rutter, W. J., Kirschner, M. W., & Cleveland, D. W. (1981) · Nature · doi:10.1038/289650a0 · Cited by 384 · see citing works
Goulding, M., Lumsden, A., & Gruss, P. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90082-s · Cited by 354 · see citing works
Goulding, M., Lumsden, A., & Gruß, P. (1993) · Development · doi:10.1242/dev.117.3.1001 · Cited by 335 · see citing works
Barth, K. A., & Wilson, S. W. (1995) · Development · doi:10.1242/dev.121.6.1755 · Cited by 332 · see citing works
Early pancreas organogenesis: Morphogenesis, tissue interactions, and mass effects
Wessells, N. K., & Cohen, J. H. (1967) · Developmental Biology · doi:10.1016/0012-1606(67)90042-5 · Cited by 318 · see citing works
Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors
Gittes, G. K., Galante, P. E., Hanahan, D., Rutter, W. J., & Debas, H. T. (1996) · Development · doi:10.1242/dev.122.2.439 · Cited by 316 · see citing works
Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.
Pourquié, O., Coltey, M., Teillet, M., Ordahl, C. P., & Douarin, N. M. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5242 · Cited by 310 · see citing works
Dorsalization of the neural tube by the non-neural ectoderm
Dickinson, M. E., Selleck, M. A. J., McMahon, A. P., & Bronner-Fraser, M. E. (1995) · Development · doi:10.1242/dev.121.7.2099 · Cited by 300 · see citing works
Li, H., Yang, J.-M., Jacobson, R. D., Pasko, D., & Sundin, O. H. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1077 · Cited by 295 · see citing works
Mesodermal patterning by an inducer gradient depends on secondary cell–cell communication
Wilson, P. A., & Melton, D. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00152-4 · Cited by 264 · see citing works
Self-citationOnset of cell-specific gene expression in the developing mouse pancreas.
Gittes, G. K., & Rutter, W. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.3.1128 · Cited by 224 · see citing works
On the origin of pancreatic endocrine cells
Douarin, N. M. L. (1988) · Cell · doi:10.1016/0092-8674(88)90375-3 · Cited by 198 · see citing works
TGF-β signals and a prepattern in Xenopus laevis endodermal development
Henry, G. L., Brivanlou, I. H., Kessler, D. S., Hemmati‐Brivanlou, A., & Melton, D. A. (1996) · Development · doi:10.1242/dev.122.3.1007 · Cited by 193 · see citing works
Self-citationInduction of motor neurons by Sonic hedgehog is independent of floor plate differentiation
Tanabe, Y., Roelink, H., & Jessell, T. M. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00130-8 · Cited by 163 · see citing works
XIHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm
Wright, C. V. E., Schnegelsberg, P. N. J., & Robertis, E. M. D. (1989) · Development · doi:10.1242/dev.105.4.787 · Cited by 162 · see citing works
Pancreatic beta cells express a diverse set of homeobox genes.
Rudnick, A., Ling, T., Odagiri, H., Rutter, W. J., & German, M. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.12203 · Cited by 154 · see citing works
The role of the neural tube and notochord in development of the axial skeleton of the chick
Watterson, R. L., Fowler, I., & Fowler, B. J. (1954) · American Journal of Anatomy · doi:10.1002/aja.1000950302 · Cited by 152 · see citing works
An early marker of axial pattern in the chick embryo and its respecification by retinoic acid
Sundin, O. H., & Gregor Eichele, C. (1992) · Development · doi:10.1242/dev.114.4.841 · Cited by 144 · see citing works
Gamer, L. W., & Wright, C. V. E. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1275 · Cited by 134 · see citing works
THE DEVELOPMENT OF THE DORSAL AND VENTRAL MAMMALIAN PANCREAS IN VIVO AND IN VITRO
Spooner, B. S., Walther, B. T., & Rutter, W. J. (1970) · The Journal of Cell Biology · doi:10.1083/jcb.47.1.235 · Cited by 128 · see citing works
Patten, B. M. (1964) · Andalas University Repository (Andalas University) · Cited by 122 · see citing works
Turque, N., Plaza, S., Radvanyi, F., Carrière, C., & Saule, S. (1994) · Molecular Endocrinology · doi:10.1210/me.8.7.929 · Cited by 118 · see citing works
Altaba, A. R. I., Placzek, M., Baldassare, M., Dodd, J., & Jessell, T. M. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1216 · Cited by 117 · see citing works
The effects of notochordectomy in Amblystoma mexicanum
Kitchin, I. C. (1949) · Journal of Experimental Zoology · doi:10.1002/jez.1401120303 · Cited by 100 · see citing works
Rosenquist, G. C. (1971) · Developmental Biology · doi:10.1016/0012-1606(71)90131-x · Cited by 97 · see citing works
Nucleotide sequence determination of chicken glucagon precursor cDNA
Hasegawa, S., Terazono, K., Nata, K., Takada, T., Yamamoto, H., & Okamoto, H. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80779-i · Cited by 53 · see citing works
Cloning, sequencing, and expressional analysis of the chick homologue of follistatin
Connolly, D. J., Patel, K., Seleiro, E. A. P., Wilkinson, D. G., & Cooke, J. (1995) · Developmental Genetics · doi:10.1002/dvg.1020170108 · Cited by 53 · see citing works
Knežević, V., Ranson, M., & Mackem, S. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1296 · Cited by 50 · see citing works
A role for CdxA in gut closure and intestinal epithelia differentiation
Frumkin, A., Pillemer, G., Haffner, R., Tarcic, N., Gruenbaum, Y., & Fainsod, A. (1994) · Development · doi:10.1242/dev.120.2.253 · Cited by 43 · see citing works
Etude immunocytologique de la différenciation du pancréas endocrine chez l'embryon de poulet
Dieterlen‐Lièvre, F., & Beaupain, D. (1974) · General and Comparative Endocrinology · doi:10.1016/0016-6480(74)90088-4 · Cited by 36 · see citing works
Etude immunocytologique de la différenciation du pancréas endocrine chez l'embryon de Poulet
Beaupain, D., & Dieterlen‐Lièvre, F. (1974) · General and Comparative Endocrinology · doi:10.1016/0016-6480(74)90040-9 · Cited by 36 · see citing works
Neural development: Patterning cascades in the neural tube
Placzek, M., & Furley, A. J. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00533-x · Cited by 31 · see citing works
Sechrist, J. W., & Marcelle, C. (1996) · Methods in cell biology · doi:10.1016/s0091-679x(08)60635-4 · Cited by 28 · see citing works
Prolonged and simplified in vitro culture of explanted chick embryos
Flamme, I. (1987) · Anatomy and Embryology · doi:10.1007/bf00309751 · Cited by 25 · see citing works
Dieterlen‐Lièvre, F. (1970) · Developmental Biology · doi:10.1016/0012-1606(70)90011-4 · Cited by 24 · see citing works
[Morphological and experimental study of the differentiation of the pancreas in the chick embryo].
Dieterlen‐Lièvre, F. (1965) · PubMed · Cited by 11 · see citing works
Sumiya, M., & MIZUNO, T. (1987) · PubMed · Cited by 7 · see citing works
Isolation of a cDNA Encoding Chicken Insulin Precursor
Hasegawa, S., Honda, K., Nata, K., Yonekura, H., OKAMOTO, H., & HIKAMI, Y. (1991) · Nihon Chikusan Gakkaiho · doi:10.2508/chikusan.62.867 · Cited by 2 · see citing works
Flagged first, then by citations
3 of the 59 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets
Lumelsky, N. L., Blondel, O., Laeng, P., Velasco, I., Ravin, R., & McKay, R. D. G. (2001) · Science · doi:10.1126/science.1058866 · Cited by 1,453 · see citing works
Induction of Pancreatic Differentiation by Signals from Blood Vessels
Lammert, E., Cleaver, O. B., & Melton, D. A. (2001) · Science · doi:10.1126/science.1064344 · Cited by 1,048 · see citing works
Self-citationNotochord repression of endodermal Sonic hedgehog permits pancreas development
Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development · doi:10.1101/gad.12.11.1705 · Cited by 628 · see citing works
Self-citationPancreas organogenesis: From bud to plexus to gland
Pan, F. C., & Wright, C. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22584 · Cited by 638 · see citing works
α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
Gromada, J., Franklin, I., & Wollheim, C. B. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0007 · Cited by 574 · see citing works
A bipotential precursor population for pancreas and liver within the embryonic endoderm
Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611 · see citing works
Krapp, A., Knöfler, M., Ledermann, B., Bürki, K., Berney, C., Zoerkler, N., Hagenbüchle, O., & Wellauer, P. K. (1998) · Genes & Development · doi:10.1101/gad.12.23.3752 · Cited by 529 · see citing works
Generation of Insulin‐Producing Islet‐Like Clusters from Human Embryonic Stem Cells
Jiang, J.-J., Au, M., Lu, K., Eshpeter, A., Korbutt, G., Fisk, G. J., & Majumdar, A. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0761 · Cited by 534 · see citing works
Pancreatic organogenesis — developmental mechanisms and implications for therapy
Edlund, H. (2002) · Nature Reviews Genetics · doi:10.1038/nrg841 · Cited by 522 · see citing works
Vertebrate Endoderm Development
Wells, J. M., & Melton, D. A. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.393 · Cited by 522 · see citing works
Self-citationBhushan, A., Itoh, N., Kato, S., Thiery, J. P., Czernichow, P., Bellusci, S., & Scharfmann, R. (2001) · Development · doi:10.1242/dev.128.24.5109 · Cited by 459 · see citing works
Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 449 · see citing works
Structure and function of the notochord: an essential organ for chordate development
Stemple, D. L. (2005) · Development · doi:10.1242/dev.01812 · Cited by 443 · see citing works
Hruban, R., Adsay, N., Albores-saavedra, J., Anver, M., Biankin, A., Boivin, G. P., Furth, E., Furukawa, T., Klein, A., Klimstra, D., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2168 · Cited by 411 · see citing works
Regulation of pancreas development by hedgehog signaling
Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.22.4905 · Cited by 412 · see citing works
Self-citationIntercellular signals regulating pancreas development and functionPreprint
Kim, S. K., & Hebrok, M. (2001) · Genes & Development · doi:10.1101/gad.859401 · Cited by 403 · see citing works
Self-citationMinireview: transcriptional regulation in pancreatic development.
Habener, J., Kemp, D. M., & Thomas, M. K. (2005) · Endocrinology · doi:10.1210/en.2004-1576 · Cited by 437 · see citing works
Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
Li, H., Arber, S., Jessell, T. M., & Edlund, H. (1999) · Nature Genetics · doi:10.1038/12669 · Cited by 377 · see citing works
Gene regulatory factors in pancreatic development
Jensen, J. (2004) · Developmental Dynamics · doi:10.1002/dvdy.10460 · Cited by 397 · see citing works
An illustrated review of early pancreas development in the mouse.
Jørgensen, M. C., Ahnfelt-Rønne, J., Hald, J., Madsen, O., Serup, P., & Hecksher-Sørensen, J. (2007) · Endocrine reviews · doi:10.1210/er.2007-0016 · Cited by 403 · see citing works
Early mouse endoderm is patterned by soluble factors from adjacent germ layers
Wells, J. M., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.8.1563 · Cited by 366 · see citing works
Self-citationPancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
Harrison, K. A., Thaler, J. P., Pfaff, S. L., Gu, H., & Kehrl, J. H. (1999) · Nature Genetics · doi:10.1038/12674 · Cited by 358 · see citing works
Development of the Human Pancreas From Foregut to Endocrine Commitment
Jennings, R. E., Berry, A. A., Kirkwood-Wilson, R., Roberts, N. A., Hearn, T., Salisbury, R. J., Blaylock, J., Hanley, K. P., & Hanley, N. (2013) · Diabetes · doi:10.2337/db12-1479 · Cited by 285 · see citing works
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
van den Brink, G. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00054.2006 · Cited by 300 · see citing works
Grapin‐Botton, A., Majithia, A. R., & Melton, D. A. (2001) · Genes & Development · doi:10.1101/gad.846001 · Cited by 296 · see citing works
Self-citationPancreas and beta-cell development: from the actual to the possible
Murtaugh, L. C. (2006) · Development · doi:10.1242/dev.02770 · Cited by 284 · see citing works
Endoderm development: from patterning to organogenesis
Grapin‐Botton, A., & Melton, D. A. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01957-5 · Cited by 279 · see citing works
Self-citationThe Pathology and Genetics of Metastatic Pancreatic Cancer
Yachida, S., & Iacobuzio–Donahue, C. A. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.3.413 · Cited by 269 · see citing works
Lack of TCF2/vHNF1 in mice leads to pancreas agenesis.
Haumaître, C., Barbacci, E., Jenny, M., Ott, M., Gradwohl, G., & Cereghini, S. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0405776102 · Cited by 281 · see citing works
Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
Kim, S. K., & Melton, D. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13036 · Cited by 265 · see citing works
Self-citationYoshitomi, H., & Zaret, K. (2004) · Development · doi:10.1242/dev.00960 · Cited by 268 · see citing works
Cirulli, V., & Yebra, M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2142 · Cited by 257 · see citing works
Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.
Martín, M., Gallego-Llamas, J., Ribes, V., Kedinger, M., Niederreither, K., Chambon, P., Dollé, P., & Gradwohl, G. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.035 · Cited by 295 · see citing works
Role of endothelial cells in early pancreas and liver development
Lammert, E., Cleaver, O. B., & Melton, D. A. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00332-5 · Cited by 254 · see citing works
Self-citationHald, J., Hjorth, J., German, M. S., Madsen, O. D., Serup, P., & Jensen, J. N. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00326-9 · Cited by 251 · see citing works
Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate
Kumar, M. E., Jordan, N., Melton, D. A., & Grapin‐Botton, A. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00183-0 · Cited by 247 · see citing works
Self-citationMolecular Regulation of Lung Development
Cardoso, W. V. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.471 · Cited by 241 · see citing works
Signaling and transcriptional control of pancreatic organogenesis
Kim, S. K. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00338-6 · Cited by 239 · see citing works
Self-citationDynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors
Wandzioch, E., & Zaret, K. (2009) · Science · doi:10.1126/science.1174497 · Cited by 249 · see citing works
Genes, Signals, and Lineages in Pancreas Development
Murtaugh, L. C., & Melton, D. A. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.144752 · Cited by 235 · see citing works
Self-citationDirect lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis.
Gu, G.-Q., Brown, J. R., & Melton, D. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00330-1 · Cited by 236 · see citing works
Self-citationFrom endoderm formation to liver and pancreas development in zebrafish
Ober, E. A., Field, H. A., & Stainier, D. Y. R. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00327-1 · Cited by 223 · see citing works
Biemar, F., Argenton, F., Schmidtke, R., Epperlein, S., Peers, B., & Driever, W. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0103 · Cited by 224 · see citing works
How to make a functional β-cell
Pagliuca, F., & Melton, D. (2013) · Development · doi:10.1242/dev.093187 · Cited by 215 · see citing works
Self-citationActivin receptor patterning of foregut organogenesis
Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A. (2000) · Genes & Development · doi:10.1101/gad.14.15.1866 · Cited by 212 · see citing works
Self-citationKim, S. K., Selleri, L., Lee, J. S., Zhang, A. Y., Gu, X., Jacobs, Y., & Cleary, M. L. (2002) · Nature Genetics · doi:10.1038/ng860 · Cited by 203 · see citing works
Self-citationFoxa2 is required for the differentiation of pancreatic α-cells
Lee, C. S., Sund, N. J., Behr, R., Herrera, P. L., & Kaestner, K. H. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.10.012 · Cited by 199 · see citing works
Brachyury downstream notochord differentiation in the ascidian embryoPreprint
Takahashi, H., Hotta, K., Erives, A. J., Gregorio, A. D., Zeller, R. W., Levine, M., & Satoh, N. (1999) · Genes & Development · doi:10.1101/gad.13.12.1519 · Cited by 197 · see citing works
Transcriptional dynamics of endodermal organ formation
Sherwood, R. I., Chen, T. A., & Melton, D. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21810 · Cited by 191 · see citing works
Self-citationSordet‐Dessimoz, J., Opoka, R. J., Kordich, J. J., Grapin‐Botton, A., & Wells, J. M. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.10.001 · Cited by 189 · see citing works
Tissue-specific deletion of Foxa2 in pancreatic β cells results in hyperinsulinemic hypoglycemiaPreprint
Sund, N. J., Vatamaniuk, M. Z., Casey, M. A., Ang, S., Magnuson, M. A., Stoffers, D. A., Matschinsky, F. M., & Kaestner, K. H. (2001) · Genes & Development · doi:10.1101/gad.901601 · Cited by 187 · see citing works
Haumaître, C., Lenoir, O., & Scharfmann, R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00413-08 · Cited by 185 · see citing works
Foxa2 Controls Pdx1 Gene Expression in Pancreatic β-Cells In Vivo
Lee, C. S., Sund, N. J., Vatamaniuk, M. Z., Matschinsky, F. M., Stoffers, D. A., & Kaestner, K. H. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2546 · Cited by 184 · see citing works
Jacquemin, P., Lemaigre, F., & Rousseau, G. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00115-5 · Cited by 187 · see citing works
Developmental biology of the pancreas.
Edlund, H. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s5 · Cited by 179 · see citing works
Burke, Z., & Oliver, G. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00240-x · Cited by 177 · see citing works
Insulin expressing cells from differentiated embryonic stem cells are not beta cells
Sipione, S., Eshpeter, A., Lyon, J. G., Korbutt, G. S., & Bleackley, R. C. (2004) · Diabetologia · doi:10.1007/s00125-004-1349-z · Cited by 176 · see citing works
Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis
Ellis, K., Bagwell, J., & Bagnat, M. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201212095 · Cited by 175 · see citing works
Miralles, F., Battelino, T., Czernichow, P., & Scharfmann, R. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.3.827 · Cited by 174 · see citing works
Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats
Li, W., Rukstalis, J. M., Nishimura, W., Tchipashvili, V., Habener, J. F., Sharma, A., & Bonner‐Weir, S. (2010) · Journal of Cell Science · doi:10.1242/jcs.065268 · Cited by 164 · see citing works
Hardikar, A. A., Marcus‐Samuels, B., Geras‐Raaka, E., Raaka, B. M., & Gershengorn, M. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232230100 · Cited by 162 · see citing works
Zaret, K. S., Watts, J. A., Xu, J., Wandzioch, E., Smale, S. T., & Sekiya, T. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.040 · Cited by 159 · see citing works
Fujitani, Y., Fujitani, S., Boyer, D. F., Gannon, M., Kawaguchi, Y., Ray, M., Shiota, M., Stein, R., Magnuson, M., & Wright, C. (2006) · Genes & Development · doi:10.1101/gad.1360106 · Cited by 181 · see citing works
Hedgehog signaling in pancreas development
Hebrok, M. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00331-3 · Cited by 157 · see citing works
Self-citationBardot, E., & Hadjantonakis, A. (2020) · Mechanisms of Development · doi:10.1016/j.mod.2020.103617 · Cited by 144 · see citing works
Leconte, I., Fox, J. C., Baldwin, H. S., Buck, C. A., & Swain, J. L. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199812)213:4 · Cited by 38 · see citing works
Pancreatic β Cell-specific Transcription of thepdx-1 Gene
Gerrish, K., GANNON, M. A., Shih, D. Q., Henderson, E., Stoffel, M., Wright, C. V. E., & Stein, R. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3485 · Cited by 155 · see citing works
Control of Cell Identity in Pancreas Development and Regeneration
Stanger, B. Z., & Hebrok, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.074 · Cited by 154 · see citing works
Self-citationHedgehog signaling regulation of insulin production by pancreatic beta-cells.
Thomas, M. K., Rastalsky, N., Lee, J. H., & Habener, J. F. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2039 · Cited by 153 · see citing works
Stabilization of β-catenin induces pancreas tumor formation
Heiser, P., Cano, D., Landsman, L., Kim, G. E., Kench, J., Klimstra, D., Taketo, M., Biankin, A., & Hebrok, M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.089 · Cited by 155 · see citing works
Self-citationPeterson, K. J., Cameron, R. A., Tagawa, K., Satoh, N., & Davidson, E. H. (1999) · Development · doi:10.1242/dev.126.1.85 · Cited by 138 · see citing works
Brolén, G., Heins, N., Edsbagge, J., & Semb, H. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2867 · Cited by 140 · see citing works
An endothelial-mesenchymal relay pathway regulates early phases of pancreas development.
Jacquemin, P., Yoshitomi, H., Kashima, Y., Rousseau, G., Lemaigre, F., & Zaret, K. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.023 · Cited by 148 · see citing works
Vaudin, P., Delanoue, R., Davidson, I., Silber, J., & Zider1, A. (1999) · Development · doi:10.1242/dev.126.21.4807 · Cited by 133 · see citing works
The notochord: structure and functions
Corallo, D., Trapani, V., & Bonaldo, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1897-z · Cited by 131 · see citing works
PDX1 is the cornerstone of pancreatic β-cell functions and identity
Ebrahim, N., Shakirova, K. S., & Dashinimaev, E. B. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1091757 · Cited by 129 · see citing works
Stomach Organ and Cell Lineage Differentiation: From Embryogenesis to Adult Homeostasis
Willet, S. G., & Mills, J. C. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.05.006 · Cited by 123 · see citing works
Bayha, E., Jørgensen, M. C., Serup, P., & Grapin‐Botton, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005845 · Cited by 121 · see citing works
Notochord Cells in Intervertebral Disc Development and Degeneration
McCann, M. R., & Séguin, C. A. (2016) · Journal of Developmental Biology · doi:10.3390/jdb4010003 · Cited by 118 · see citing works
Retinoids signal directly to zebrafish endoderm to specify insulin -expressing β-cells
Stafford, D. A., White, R. J., Kinkel, M. D., Linville, A., Schilling, T. F., & Prince, V. (2006) · Development · doi:10.1242/dev.02263 · Cited by 118 · see citing works
Committing Embryonic Stem Cells to Early Endocrine Pancreas In Vitro
Ku, H. T., Zhang, N., Kubo, A., O'Connor, R., Mao, M., Keller, G. M., & Bromberg, J. S. (2004) · Stem Cells · doi:10.1634/stemcells.2004-0027 · Cited by 118 · see citing works
Pancreas: how to get there from the gut?
Edlund, H. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00033-2 · Cited by 118 · see citing works
Signals from the neural crest regulate beta-cell mass in the pancreas
Nekrep, N., Wang, J., Miyatsuka, T., & German, M. S. (2008) · Development · doi:10.1242/dev.015859 · Cited by 115 · see citing works
Sonic hedgehog Is Required Early in Pancreatic Islet Development
diIorio, P. J., Moss, J. B., Sbrogna, J. L., Karlstrom, R. O., & Moss, L. G. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0573 · Cited by 115 · see citing works
Notochord Patterning of the Endoderm
Cleaver, O., & Krieg, P. A. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0214 · Cited by 114 · see citing works
Analysis of pancreatic development in living transgenic zebrafish embryos
Huang, H., Vogel, S. S., Liu, N., Melton, D. A., & Lin, S. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00408-7 · Cited by 114 · see citing works
Self-citationDisruption of thetalin gene arrests mouse development at the gastrulation stage
Monkley, S. J., Zhou, X.-H., Kinston, S., Giblett, S. M., Hemmings, L., Priddle, H., Brown, J., Pritchard, C. A., Critchley, D. R., & F�ssler, R. (2000) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 218 · see citing works
Gleiberman, A. S., Fedtsova, N. G., & Rosenfeld, M. G. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9386 · Cited by 112 · see citing works
A conserved role for retinoid signaling in vertebrate pancreas development
Stafford, D. A., Hornbruch, A., Mueller, P. R., & Prince, V. (2004) · Development, Genes and Evolution · doi:10.1007/s00427-004-0420-6 · Cited by 114 · see citing works
The Mesenchyme Controls the Timing of Pancreatic β-Cell Differentiation
Duvillié, B., Attali, M., Bounacer, A., Ravassard, P., Basmaciogullari, A., & Scharfmann, R. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-0839 · Cited by 109 · see citing works
GANNON, M. A., Gamer, L. W., & Wright, C. V. E. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0359 · Cited by 108 · see citing works
Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo
Roy, S., Qiao, T., Wolff, C., & Ingham, P. W. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00402-x · Cited by 107 · see citing works
Control of β-Cell Differentiation by the Pancreatic Mesenchyme
Attali, M., Stetsyuk, V., Basmaciogullari, A., Aiello, V., Zanta-Boussif, M., Duvillié, B., & Scharfmann, R. (2007) · Diabetes · doi:10.2337/db06-1307 · Cited by 91 · see citing works
Scharfmann, R. (2000) · Diabetologia · doi:10.1007/s001250051498 · Cited by 105 · see citing works
Bonal, C., Thorel, F., Ait‐Lounis, A., Reith, W., Trumpp, A., & Herrera, P. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.015 · Cited by 103 · see citing works
Shiraki, N., Yoshida, T., Araki, K., Umezawa, A., Higuchi, Y., Goto, H., Kume, K., & Kume, S. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0608 · Cited by 102 · see citing works
Stem cells to pancreatic beta-cells: new sources for diabetes cell therapy.
Guo, T.-X., & Hebrok, M. (2009) · Endocrine reviews · doi:10.1210/er.2009-0004 · Cited by 108 · see citing works
Self-citationHedgehog signaling regulates expansion of pancreatic epithelial cells
Kawahira, H., Scheel, D. W., Smith, S. B., German, M. S., & Hebrok, M. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.008 · Cited by 97 · see citing works
Self-citationPancreas development and diabetes
St‐Onge, L., Wehr, R., & Grusst, P. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80044-6 · Cited by 97 · see citing works
Negative Regulation of Midline Vascular Development by the Notochord
Reese, D. E., Hall, C. E., & Mikawa, T. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00127-3 · Cited by 95 · see citing works
- Authors
- Kim, S. K., Hebrok, M., & Melton, D. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-11-01
- Volume
- 124
- Issue
- 21
- Pages
- 4243-4252
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1844743435
- Cited by
- 405
- References
- 59
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 12 · 2012: 14
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Renal and related cancers
- Keywords
- notochord, endoderm, pancreatic development, dorsal pancreas, insulin, glucagon, carboxypeptidase A, chick embryo, in vitro recombination
- MeSH terms
- Animals, Cells, Cultured, Chick Embryo, Embryonic Induction, Endoderm, Nerve Tissue Proteins, Notochord, Pancreas, Transcription Factors, Signal Transduction, Biomarkers, Trans-Activators, Homeodomain Proteins, Gene Expression Regulation, Developmental, LIM-Homeodomain Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review