The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Intracellular BMP Signaling Regulation in Vertebrates: Pathway or Network?
Open accessAbstract
Bone morphogenetic proteins (BMPs), members of the TGF-beta superfamily of secreted signaling molecules, have important functions in many biological contexts. They bind to specific serine/threonine kinase receptors, which transduce the signal to the nucleus through Smad proteins. The question of how BMPs can have such diverse effects while using the same canonical Smad pathway has recently come closer to an answer at the molecular level. Nuclear cofactors have been identified that cooperate with the Smads in regulating specific target genes depending on the cellular context. In addition, the pivotal role BMP signaling plays is underscored by the identification of factors that regulate members of this pathway at the cell surface, in the cytoplasm, and in the nucleus. Many of these factors are BMP-inducible and inhibit the BMP pathway, thus establishing negative feedback loops. Members of the BMP-Smad pathway can also physically interact with components of other signaling pathways to establish crosstalk. Finally, there is accumulating evidence that an alternative pathway involving MAP kinases can transduce BMP signals. The evidence and implications of these findings are discussed with an emphasis on early embryonic development of Xenopus and vertebrates.
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Cites
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Cited by
Bone morphogenetic proteins: a critical review
Bragdon, B., Moseychuk, O., Saldanha, S., King, D., Julian, J., & Nohe, A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.003 · Cited by 691
Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
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An essential role of Bmp4 in the atrioventricular septation of the mouse heart
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Boström, K., Zebboudj, A. F., Yao, Y., Lin, T. S., & Torres, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406868200 · Cited by 112
Metadata
- Authors
- von Bubnoff, A., & Cho, K. W. Y.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 239
- Issue
- 1
- Pages
- 1-14
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1979518793
- Cited by
- 393
- References
- 137
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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