The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Time-Lapse Analysis of Living Mouse Germ Cell Migration
Open accessAbstract
In mouse embryos, the primordial germ cells arise during gastrulation prior to, and distant from, the prospective gonads. Observations of PGCs in culture, and in fixed sections, have suggested, but not proved, that they migrate to the gonad by a process of active migration. The opaque nature of the early mouse embryo has precluded direct observation. Using confocal microscopy, we have filmed living PGCs expressing eGFP in tissue slices from mouse embryos at different stages of development. We find four clearly distinct phases of PGC migration. First, until E9.0-E9.5, PGCs are already highly motile, but do not leave the gut. Second, in the E9.0-E9.5 period, before the mesentery forms, PGCs very rapidly exit the gut, but do not migrate towards the genital ridges. Third, during the E10.0-E10.5 period, PGCs migrate directionally from the dorsal body wall into the genital ridges. In contrast to the prevailing model of germ cell migration, very few, if any, PGCs found in the gut mesentery at E10.5 migrate into the genital ridges. Finally, at E11.5, PGCs are slowing and the direction of movement is dependent on the sex of the embryo. This allows, for the first time, a formal description of the events of PGC migration in the mouse.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The onset of germ cell migration in the mouse embryo
Anderson, R., Copeland, T. K., Schöler, H., Heasman, J., & Wylie, C. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00271-3 · Cited by 313
Self-citationMigratory and postmigratory mouse primordial germ cells behave differently in culture
Donovan, P. (1986) · Cell · doi:10.1016/0092-8674(86)90005-x · Cited by 269
Interactions between primordial germ cells play a role in their migration in mouse embryos
Gomperts, M., Garcia-Castro, M., Wylie, C., & Heasman, J. (1994) · Development · doi:10.1242/dev.120.1.135 · Cited by 236
Self-citationProliferation and migration of primordial germ cells in We/We mouse embryos
Buehr, M., McLaren, A., Bartley, A., & Darling, S. (1993) · Developmental Dynamics · doi:10.1002/aja.1001980304 · Cited by 190
The role of cadherins during primordial germ cell migration and early gonad formation in the mouse
Bendel-Stenzel, M. R., Gomperts, M., Anderson, R., Heasman, J., & Wylie, C. C. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00287-7 · Cited by 161
Self-citationGodin, I., & Wylie, C. C. (1991) · Development · doi:10.1242/dev.113.4.1451 · Cited by 160
Self-citationGodin, I., Wylie, C., & Heasman, J. (1990) · Development · doi:10.1242/dev.108.2.357 · Cited by 159
Self-citationIdentification of genes controlling germ cell migration and embryonic gonad formation in Drosophila
Moore, L. A., Broihier, H. T., Doren, M. V., Lunsford, L. B., & Lehmann, R. (1998) · Development · doi:10.1242/dev.125.4.667 · Cited by 139
The active migration of Drosophila primordial germ cells
Jaglarz, M. K., & Howard, K. R. (1995) · Development · doi:10.1242/dev.121.11.3495 · Cited by 121
Response to fibronectin of mouse primordial germ cells before, during and after migration
ffrench‐Constant, C., Hollingsworth, A., Heasman, J., & Wylie, C. C. (1991) · Development · doi:10.1242/dev.113.4.1365 · Cited by 79
Self-citation
Cited by
The role of m6A modification in the biological functions and diseases
Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
Boisset, J.-C., van Cappellen, W., Andrieu-Soler, C., Galjart, N., Dzierzak, E., & Robin, C. (2010) · Nature · doi:10.1038/nature08764 · Cited by 917
Guidance of Primordial Germ Cell Migration by the Chemokine SDF-1
Doitsidou, M., Reichman-Fried, M., Stebler, J., Köprunner, M., Dörries, J., Meyer, D., Esguerra, C. V., Leung, T., & Raz, E. (2002) · Cell · doi:10.1016/s0092-8674(02)01135-2 · Cited by 697
Primordial germ cells in the mouse
McLaren, A. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00214-8 · Cited by 657
In toto imaging and reconstruction of post-implantation mouse development at the single-cell level
McDole, K., Guignard, L., Amat, F., Berger, A., Malandain, G., Royer, L. A., Turaga, S. C., Branson, K., & Keller, P. J. (2018) · Cell · doi:10.1016/j.cell.2018.09.031 · Cited by 522
Metadata
- Authors
- Molyneaux, K. A., Stallock, J., Schaible, K., & Wylie, C.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 240
- Issue
- 2
- Pages
- 488-498
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2043396979
- Cited by
- 337
- References
- 12
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Time-Lapse Analysis of Living Mouse Germ Cell Migration. https://app.cochat.ai/papers/10.1006/dbio.2001.0436
- The paper
- Molyneaux, K. A., Stallock, J., Schaible, K., & Wylie, C. (2001). Time-Lapse Analysis of Living Mouse Germ Cell Migration. Developmental Biology. https://doi.org/10.1006/dbio.2001.0436
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
