Hydrodynamics of ageing Bruch’s membrane: Implications for macular disease
Abstract
The hydrodynamic properties of isolated human Bruch's membrane and choroid were investigated as a function of age and retinal location. Macular and peripheral regions of the fundus showed an exponential decline of hydraulic conductivity with half-lives of 15 and 22 years respectively. Comparison of age profiles for hydraulic conductivity and lipid deposits suggests the involvement of two discrete processes for reduction in transport capability. The first appears to involve 'membrane remodelling' with a programmed decay rate leading to a major reduction in hydraulic conductivity by the fifth decade of life. The second commences in the fourth decade and is apparently dependent on the lipid content of Bruch's membrane.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The movement of water across BrM, as measured with Ussing chambers, decreases with age.
“The movement of water across BrM, as measured with Ussing chambers [60,61,62,63], decreases with age.”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [61]
The citation lists haven’t been fetched yet
Cited by 170
- Authors
- STARITA, C., HUSSAIN, A. A., PAGLIARINI, S., & MARSHALL, J.
- Affiliations
- Guy's Hospital (GB)
- Corresponding author
- STARITA, CARLA
- Venue
- Experimental Eye Research
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 62
- Issue
- 5
- Pages
- 565-572
- ISSN
- 0014-4835 (ISSN-L)
- OpenAlex
- W2025398169
- Cited by
- 170
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 6 · 2012: 15
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Eye Research (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Macular Society
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- Bruch's membrane, aging, choroid, hydraulic conductivity, maculopathy, membrane remodeling, lipid deposits, age-related decline
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Cell Membrane Permeability, Child, Child, Preschool, Choroid, Humans, Infant, Middle Aged, Water, Bruch Membrane
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
