The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Increased Caspase 3 and Bax Immunoreactivity Accompany Nuclear GAPDH Translocation and Neuronal Apoptosis in Parkinson's Disease
Open accessAbstract
In situ end labeling combined with YOYO staining was used to mark apoptotic DNA fragmentation and chromatin condensation respectively in human postmortem brain sections. Increased numbers of apoptotic neuronal nuclei were identified in the Parkinson's disease (PD) nigra compared with age-matched controls. Caspase 3 and Bax showed increased immunoreactivity in melanized neurons of the PD nigra compared with controls. Importantly, GAPDH nuclear accumulation was also observed in the PD nigra, suggesting apoptotic rather than necrotic cell death. Interestingly, both Lewy bodies and the intranuclear Marinesco's bodies were GAPDH immunoreactive in the PD brain.
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Metadata
- Authors
- Tatton, N. A.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 166
- Issue
- 1
- Pages
- 29-43
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W1965575645
- Cited by
- 411
- References
- 64
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tatton, N. A. (2000). Increased Caspase 3 and Bax Immunoreactivity Accompany Nuclear GAPDH Translocation and Neuronal Apoptosis in Parkinson's Disease. Experimental Neurology. https://doi.org/10.1006/exnr.2000.7489
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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