In Situ and in Vitro Study of Colocalization and Segregation of α-Synuclein, Ubiquitin, and Lipids in Lewy Bodies
Gai, W.P., Yuan, H.X., Li, X.Q., Power, J.T.H., Blumbergs, P.C., Jensen, P.H.·2000·Experimental Neurology
Cited by (272)
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- α-Synuclein Interaction with Lipid Bilayer DiscsMarija Dubackic, Yun Liu, Elizabeth G. Kelley, Crispin J. D. Hetherington, Michael Haertlein, Juliette M. Devos, Sara Snogerup Linse, Emma Sparr, Ulf Olsson · 2022 · Langmuir
- Chaperone proteins identified from synthetic proteasome inhibitor-induced inclusions in PC12 cells by proteomic analysisXing'an Li, Yingjiu Zhang, Yihong Hu, Ming Chang, Tao Liu, Danping Wang, Yu Zhang, Lei Zhang, Linsen Hu · 2008 · Acta Biochimica et Biophysica Sinica
- Ultrastructural diversity and subcellular organization of nigral Lewy pathology in Parkinson’s diseaseAmanda J. Lewis, Lukas van den Heuvel, Marta Di Fabrizio, Kaliya Bandelier, Daria Proniakova, Domenic Burger, Notash Shafiei, Kazadi Ekundayo, Selene Offringa, Evelien Huisman et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Modulation of Alpha-Synuclein Conformational Ensemble and Aggregation Pathways by Dopamine and Related MoleculesAntonino Natalello, Stefania Brocca, Erika Ponzini, Carlo Santambrogio, Rita Grandori · 2023 · Frontiers in Bioscience-Landmark
- Alpha‐Synuclein Demonstrates Varying Binding Affinities With Different Tau IsoformsAnna‐Lisa Fischer, Matthias Schmitz, Tobias Thom, Saima Zafar, Neelam Younas, Susana Correia, Angela da Silva Correia, Sezgi Canaslan, Inga Zerr · 2025 · Journal of Neurochemistry
- A reassessment of the Lewy body.Wing Lok Au, Donald B. Calne · 2005 · PubMed
- Apoptosis vs Nonapoptotic Mechanisms in NeurodegenerationK. A. Jellinger · 2003 · Humana Press eBooks
- Dysregulation of a Heme Oxygenase–Synuclein Axis in Parkinson DiseaseMarisa Cressatti, Hyman M. Schipper · 2022 · NeuroSci
- Etiology and Progression of Parkinson's Disease: Cross-Talk Between Environmental Factors and Genetic VulnerabilityPierre‐Olivier Fernagut · 2016 · Handbook of behavioral neuroscience
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- Mapping the Role of Monomer Conformation in the Amyloid Formation of α-Synuclein Splice VariantsKatherine M. Dewison, Alexander I. P. Taylor, David J. Brockwell, Sheena E. Radford · 2025 · Journal of the American Chemical Society
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- Modeling Parkinson’s pathology in human iPSC dopaminergic neurons uncovers key mechanisms of Lewy body formation and heterogeneityAnne‐Laure Mahul‐Mellier, Lukas van den Heuvel, Maxime Teixeira, Manel L. N. Boussouf, Gaspard Oudinot, Amelie Thonet, Davide Speri, Yllza Jasiqi, Christina H. Ulrich, Razan Sheta et al. · 2026 · Science Advances
- Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated ToxicityPriyanka Singh, Nagesh Y. Kadam, Rajlaxmi Panigrahi, Arpit Mehrotra, Krishna Upadhayay, Madhumita Dey, Arpit Tyagi, Muhammad Aquib, Janni Nielsen, Giulia Kleijwegt et al. · 2025 · ACS Chemical Neuroscience
- Demência com corpúsculos de Lewy: uma entidade distinta com tratamento específico?Mariana Tatsch, Ricardo Nitríni, Mario Rodrigues Louzã · 2002 · Brazilian Journal of Psychiatry
- Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue ModelLouise Alessandra Mesentier-Louro, Camille Goldman, Sebastian Gaese, Alice Buonfiglioli, Dimitrios Kyriakis, Ashley Harlock, Alain Ndayisaba, Emily R. Sartori, Abigail Uchitelev, John F. Fullard et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)Salinas-Rebolledo, Constanza, Blesa, Javier, Valenzuela-Nieto, Guillermo, Schwefel, David, López-González del Rey, Natalia, Méndez-Ruette, Maxs, Burkhalter, Janine, Carrazana, Elizabeth, Díaz-Tejeda, Francisca, Arias Catalán, Ignacio et al. · 2025 · eLife
- Lipid-packing defects are sufficient to modulate membrane insertion and the bound state of α-synucleinMiah J. Turke, Krishna M. Raghavan, Sofiya Maltseva, Daniel Henry Solz Kerr, Erin J. Adams, Ka Yee C. Lee · 2025 · Proceedings of the National Academy of Sciences
- Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and LipidsManuel Flores‐León, Tiago F. Outeiro · 2025 · Movement Disorders
- Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathyManuel Flores‐León, Tiago F. Outeiro · 2025 · FEBS Journal
- Glycoconjugate journal special issue on: the glycobiology of Parkinson’s diseaseInka Brockhausen, John S. Schutzbach, Jiabei Wang, Beth Fishwick, Jennifer Brockhausen · 2021 · Glycoconjugate Journal
- A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversitySenthil T. Kumar, Anne‐Laure Mahul‐Mellier, Ramanath Narayana Hegde, Rani Moons, Pedro Magalhães, Alain Ibáñez de Opakua, Gwladys Rivière, Iman Rostami, Sonia Donzelli, Markus Zweckstetter et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- A dual hit of α-synuclein internalization and immune challenge leads to the formation and maintenance of Lewy body-like inclusions in human dopaminergic neuronsArmin Bayati, Riham Ayoubi, Adriana Aguila, Cornelia E. Zorca, Chanshuai Han, Emily Banks, Emmanuelle Nguyen, Wen Luo, Irina Shlaifer, Esther del Cid‐Pellitero et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrainsLouise Alessandra Mesentier-Louro, Camille Goldman, Sebastian Gaese, Alice Buonfiglioli, Dimitrios Kyriakis, Ashley Harlock, Alain Ndayisaba, Emily Ruth Sartori, Abigail Uchitelev, John F. Fullard et al. · 2026 · Cell stem cell
- Prenatal exposure to methanol as a dopamine system sensitization model in C57BL/6J miceVeronica Mackey, Gladson Muthian, Marquitta Smith, Jennifer M. King, Clivel G. Charlton · 2012 · Life Sciences
- Gene Transfer into the Central and Peripheral Nervous System: Applications for the Treatment of Neurodegenerative Diseases and Peripheral NeuropathiesPierre‐François Pradat, Jacques J. Mallet · 2003 · Biotechnology and Genetic Engineering Reviews
- α-Synuclein enhances bioluminescent activity of firefly luciferase by facilitating luciferin localizationJe-Hoon Kim, Chung Hee Moon, Seunho Jung, Seung R. Paik · 2008 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Upregulation of α-synuclein expression in the rat cerebellum in experimental hepatic encephalopathyI. Suárez, Guillermo Bodega, Benjamı́n Fernández · 2010 · Neuropathology and Applied Neurobiology
- The Role of Copper Ion and the Ubiquitin System in Neurodegenerative DisordersFabio Arnesano · 2010 · Wiley eBooks
- Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodiesHilal Ahmed Lashuel, Anne‐Laure Mahul‐Mellier, Salvatore Novello, Ramanath Narayana Hegde, Yllza Jasiqi, Melek Firat Altay, Sonia Donzelli, Sean M. DeGuire, Ritwik Burai, Pedro Magalhães et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Using yeast as a model system for the genetic dissection of α-synuclein toxicityVicente Sancenón, Sue-Ann Lee, Paul J. Muchowski · 2008 · Elsevier eBooks
- Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain lengthDominika Hajdúchová, Roman Holič, Peter Gajdoš, Milan Čertík, Erika Halášová, Renata Péčová, Michal Pokusa · 2022 · General Physiology and Biophysics
- Identification of differentially co-expressed genes with lipid metabolism in Parkinson’s disease by bioinformatics analysisJinxiao Song, Xinyao Wang, Lipeng Dong, Shuo Hui, Ziyu Huang, Ling Fan, Yongtao Zhu, Jingru Zhao · 2025 · Neuroscience
- HMGCR genetic variability in Parkinson’s disease in a Spanish cohort: associations with lipid metabolism and early onsetRafael Díaz Belloso, Miguel Martín‐Bórnez, Daniel Macías‐García, Sergio García‐Díaz, Marta Bonilla‐Toribio, Dolores Buiza‐Rueda, Rocío Pineda Sánchez, Laura Muñoz‐Delgado, Elena Ojeda–Ruiz, Silvia Jesús et al. · 2025 · Journal of Neurology
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- Correlative ultrastructural mapping of Lewy pathology reveals regional diversity in Parkinson’s and dementia with Lewy bodiesNotash Shafiei, Daria Proniakova, Marija Simjanoska, Anniken Mathea Rafnum Sjødal, Daniel A. Stähli, Lukas van den Heuvel, Marta Di Fabrizio, Eve Aaron, Sandor Kasas, Mathis Solal Krause et al. · 2026 · Acta Neuropathologica
- Colocalization of Parkin with α-Synuclein in the Lewy Bodies of Parkinson DiseaseMichael G. Schlossmacher, Matthew P. Frosch, Wei Gai, Nutan Sharma, Miguel Medina, Tomoyo Ochiishi, Hideki Shimura, Nobutaka Hattori, Yoshikuni Mizuno, Bradley T. Hyman et al. · 2002 · Advances in behavioral biology
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- The Aggresome: Proteasomes, Inclusion Bodies, and Protein AggregationJennifer A. Johnston · 2007 · Springer eBooks
- Tyrosine hydroxylase and Lewy body molecules immunoreactivity in the SNC neurons of an AS/AGU mutantratAbdullah G. Al-Kushi, D. Russell, Philip Payne · 2012 · World Journal of Neuroscience
- Acute and chronic administration of 1-methyl-4-phenylpyridiniumPatricia K. Sonsalla, Gail Duffy Zeevalk, Dwight C. German · 2008 · Elsevier eBooks
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- Oligomerization, Degradation and Aggregation Reactions and Products of Synuclein Polypeptides Related to Parkinson’s DiseaseCamelia Vlad · 2011 · KOPS (University of Konstanz)
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- A mutation in protein kinase C-gamma alters SNC neuron morphology and decreases synaptic vesicles in dopaminergic striatal terminals in the AS/AGU ratAbdullah G. Al-Kushi, David Russell, Anthony Philip Payne · 2013 · Journal of Biomedical Science and Engineering
- Accumulating Evidence Suggests that Parkinson’s Disease Is a Prion-Like DisorderNolwen L. Rey, Élodie Angot, Christopher J.R. Dunning, Jennifer A. Steiner, Patrik Brundin · 2013 · Research and perspectives in Alzheimer's disease
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- Yeast Cells as a Discovery Platform for Parkinson's Disease and other Protein Misfolding DiseasesKaren L. Allendoerfer, Linhui Julie Su, Susan Lee Lindquist · 2008 · Elsevier eBooks
- α-synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased uptake into neuronsAmberley D. Stephens, Ana Fernández‐Villegas, Chyi Wei Chung, Oliver Vanderpoorten, Dorothea Pinotsi, Ioanna Mela, Edward Ward, Thomas M. McCoy, R. Cubitt, Alexander F. Routh et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Cross-talk between genetic and environmental factors in Parkinson's diseasePierre‐Olivier Fernagut, Benjamin Dehay · 2025 · Handbook of behavioral neuroscience
- Correlative Ultrastructural Mapping of Lewy Pathology Reveals Regional Diversity in Parkinson’s and Dementia with Lewy bodiesNotash Shafiei, Daria Proniakova, Marija Simjanoska, Anniken Mathea Rafnum Sjødal, Daniel A. Stähli, Lukas van den Heuvel, Marta Di Fabrizio, Eve Aaron, Sandor Kasas, Mathis Solal Krause et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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