Cited by 96Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatmentsHereditary Neurological Disorders

Effects of an Inhibitor of Poly(ADP-Ribose) Polymerase, Desmethylselegiline, Trientine, and Lipoic Acid in Transgenic ALS Mice

Andreassen, Ole A., Dedeoglu, Alpaslan, Friedlich, Avi, Ferrante, Kimberly L., Hughes, Duncan, Szabo, Cesar, Beal, M.Flint·2001·Experimental Neurology

Abstract

The development of transgenic mouse models of amyotrophic lateral sclerosis (ALS) allows the testing of neuroprotective agents. We evaluated the effects of five agents in transgenic mice with the G93A Cu,Zn superoxide dismutase mutation. A novel inhibitor of poly(ADP-ribose) polymerase showed no effects on survival. Desmethylselegiline and CGP3466 are agents that exert antiapoptotic effects in vitro by preventing nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase. They had no significant effects on survival in the G93A mice. Trientine, a copper chelator, produced a modest significant increase in survival. Similarly administration of lipoic acid in the diet produced a significant improvement in survival. These results therefore provide evidence for potential therapeutic effects of copper chelators and lipoic acid in the treatment of ALS.

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Registry

Crossref · 10.1006/exnr.2001.7633

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  • α-lipoic acid exerts significant neuroprotective effects in transgenic mouse models of HD and ALS.

    “We found that α-lipoic acid exerts significant neuroprotective effects in transgenic mouse models of HD and ALS128, 187, 188.”

    From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [188]

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Authors
Andreassen, O. A., Dedeoglu, A., Friedlich, A., Ferrante, K. L., Hughes, D., Szabo, C., & Beal, M. F.
Affiliations
  • Harvard University (US)
  • NewYork–Presbyterian Hospital (US)
Venue
Experimental Neurology
Publisher
Elsevier BV
Published
2001-04
Volume
168
Issue
2
Pages
419-424
ISSN
0014-4886 (ISSN-L)
OpenAlex
W2057312726
Cited by
96
References
36
Citations by year
2026: 5 · 2025: 6 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 8 · 2012: 2
FWCI
5.19
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Defense
  • ALS Association
  • National Institute on Aging (P01-AG12292)
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Keywords
amyotrophic lateral sclerosis, PARP inhibitors, triethylenetetramine, copper chelation, alpha-lipoic acid, neuroprotection, survival, apoptosis
MeSH terms
Poly(ADP-ribose) Polymerase Inhibitors, Amphetamines, Amyotrophic Lateral Sclerosis, Animals, Female, Thioctic Acid, Male, Mice, Transgenic, Motor Skills, Survival, Trientine, Weight Loss, Neuroprotective Agents, Mice

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