Impact of nutrients on cellular lipid peroxidation and antioxidant defense system
Abstract
A symposium entitled Impact of Nutrients on Cellular Lipid Peroxidation and Antioxidant Defense System was held at the 33rd Annual Meeting of the Society of Toxicology (SOT) at the Loews Anatole Hotel in Dallas, Texas. The symposium was sponsored by the Food Safety Specialty Section and focused on the role of particular nutrients in cellular lipid peroxidation and antioxidant defense system. Emphasis was placed on defining underlying mechanisms for damage and protection, as well as potential ramification in human health issues. The following are extractions of some of the highlights from each presentation.
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The antioxidant properties of vitamin C protect the skin, especially the epidermis, against oxidants generated by ultraviolet radiation and other environmental factors.
“The antioxidant properties of vitamin C protect the skin, especially the epidermis, against oxidants generated by ultraviolet radiation and other environmental factors.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [60]
Vitamin C significantly curtails lipid oxidation by regenerating fat-soluble vitamin E; it regenerates α-tocopherol from α-tocopherol radicals found in cell membranes and lipoproteins.
“Although the direct antioxidant protection provided by vitamin C is limited to aqueous compartments, vitamin C significantly curtails lipid oxidation by regenerating fat-soluble vitamin E; it regenerates α-tocopherol from α-tocopherol radicals found in cell membranes and lipoproteins [60].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [60]
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Flora, S. J. S. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.4.9112 · Cited by 619 · see citing works
Patra, R. C., Swarup, D., & Dwivedi, S. K. (2001) · Toxicology · doi:10.1016/s0300-483x(01)00345-6 · Cited by 433 · see citing works
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Kalia, K., & Flora, S. J. S. (2005) · Journal of Occupational Health · doi:10.1539/joh.47.1 · Cited by 312 · see citing works
Environmental occurrence, health effects and management of lead poisoning
Flora, S. J. S., Flora, G., & Saxena, G. (2006) · Elsevier eBooks · doi:10.1016/b978-044452945-9/50004-x · Cited by 282 · see citing works
Sulfur in human nutrition and applications in medicine.
Parcell, S. (2002) · PubMed · Cited by 239 · see citing works
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Gupta, R. S., Gupta, E. S., Dhakal, B. K., et al. (2004) · Molecules and Cells · doi:10.1016/s1016-8478(23)13017-2 · Cited by 214 · see citing works
Flora, S. J. S., Bhadauria, S., Kannan, G. M., & Singh, N. (2007) · PubMed · Cited by 200 · see citing works
The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice
Weng, D., Lu, Y., Wei, Y., et al. (2006) · Toxicology · doi:10.1016/j.tox.2006.12.010 · Cited by 187 · see citing works
Flora, S. J. S., Pande, M., & Mehta, A. K. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(03)00025-5 · Cited by 171 · see citing works
Effects of vitamin E and/or C on reactive oxygen species-related lead toxicity in the rat sperm
Hsu, P., Liu, M., Hsu, C., et al. (1998) · Toxicology · doi:10.1016/s0300-483x(98)00068-7 · Cited by 167 · see citing works
Palaniappan, M., Thiruppathi, M., Balasubramanian, K., et al. (2005) · Free Radical Research · doi:10.1080/10715760500308154 · Cited by 126 · see citing works
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BackgroundProtective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat
Heidarian, E., & Rafieian‐Kopaei, M. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2013.777931 · Cited by 110 · see citing works
“Lead induces oxidative stress in the body by the generation of reactive oxygen species (ROS) and decreasing the cell antioxidant defense system.”
α-Tocopherol modulates liver toxicity of the pyrethroid cypermethrin
Aldana, L., Tsutsumi, V., Craigmill, A. L., et al. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(01)00427-1 · Cited by 77 · see citing works
Antioxidant properties of S-adenosyl-l-methionine in Fe2+-initiated oxidations
Caro, A. A., & Cederbaum, A. I. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.015 · Cited by 70 · see citing works
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Awadalla, E. A. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.10.009 · Cited by 70 · see citing works
Shadnia, S., Dasgar, M., Taghikhani, S., et al. (2007) · Toxicology Mechanisms and Methods · doi:10.1080/15376510600860318 · Cited by 65 · see citing works
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Gazzani, G., Papetti, A., Daglia, M., et al. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980301g · Cited by 62 · see citing works
Omaye, S. T., Krinsky, N. I., Kagan, V. E., Mayne, S. T., Liebler, D. C., & Bidlack, W. R. (1997) · Toxicological Sciences · doi:10.1093/toxsci/40.2.163 · Cited by 54 · see citing works
In vitro and ex vivo anti- and prooxidant components of Cichorium intybus
Gazzani, G., Daglia, M., Papetti, A., et al. (2000) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(00)00282-x · Cited by 53 · see citing works
Prieto, A. I., Jos, A. M., Pichardo, S., et al. (2008) · Environmental Toxicology · doi:10.1002/tox.20458 · Cited by 48 · see citing works
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Rana, T., Bera, A. K., Das, S., Pan, D., Bandyopadhyay, S., Bhattacharya, D., De, S., Sikdar, S., & Das, S. K. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.01.027 · Cited by 47 · see citing works
Papel dos nutrientes na peroxidação lipídica e no sistema de defesa antioxidante
Vannucchi, H., Moreira, E. A. M., da Cunha, D. F., et al. (1998) · Medicina (Ribeirão Preto) · doi:10.11606/issn.2176-7262.v31i1p31-44 · Cited by 42 · see citing works
Gupta, R., & Flora, S. J. S. (2006) · Human & Experimental Toxicology · doi:10.1191/0960327106ht636oa · Cited by 41 · see citing works
Sönmez, M. F., Narin, F., Akkuş, D., & Türkmen, A. B. (2012) · Renal Failure · doi:10.3109/0886022x.2011.649678 · Cited by 39 · see citing works
El‐Sokkary, G. H. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00503.x · Cited by 39 · see citing works
Yang, F., Zhuo, L., Ananda, S., et al. (2011) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-011-0377-4 · Cited by 32 · see citing works
Patra, R. C., & Swarup, D. (2004) · Cited by 32 · see citing works
Sahoo, S. S., Patra, R. C., Behera, P. C., & Swarup, D. (2008) · Veterinary Research Communications · doi:10.1007/s11259-008-9176-1 · Cited by 29 · see citing works
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BackgroundJúnior, A. A. J., Chiarello, P. G., Bernardes, M. M., et al. (1998) · Medicina (Ribeirão Preto) · doi:10.11606/issn.2176-7262.v31i3p434-449 · Cited by 24 · see citing works
Fluoride-induced neuronal oxidative stress and its amelioration by antioxidants in developing rats.
Madhusudhan, N., Basha, P. M., Begum, S., et al. (2009) · Fluoride · Cited by 20 · see citing works
Wongsrikeao, P., Nagai, T., Budiyanto, A., et al. (2006) · Molecular Reproduction and Development · doi:10.1002/mrd.20640 · Cited by 20 · see citing works
“On the other hand, vitamin E (a-tocopherol) and vitamin C (ascorbic acid) are low molecular mass antioxidants that interact directly with the oxidizing radicals (Burton and Ingold, 1986; Jones et al., 1995) and protect the cells from reactive oxygen species.”
BackgroundPerocco, P., Mazzullo, M., Broccoli, M., et al. (2000) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(99)00223-5 · Cited by 20 · see citing works
Guzmán‐Guillén, R., Prieto, A. I., Gutiérrez‐Praena, D., et al. (2015) · Environmental Toxicology · doi:10.1002/tox.22152 · Cited by 14 · see citing works
“a lipid-soluble antioxidant which reduces free radicalmediated oxidation of unsaturated fatty acids, thereby protecting biological membranes, lipoproteins, and lipid stores against oxidation (Jones et al., 1995; Hamre et al., 1998; Hung et al., 2007).”
BackgroundInfluentialMohamed, E. T., Mahran, H. A., & Mahmoud, M. S. (2010) · Cited by 13 · see citing works
Hermes-Uliana, C., Frez, F. C. V., Sehaber, C. C., Ramalho, F. V., Neto, F. P. D. S., Cecchini, R., Guarnier, F. A., & Zanoni, J. N. (2018) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2018.05.002 · Cited by 11 · see citing works
Oxidative Stress and Antioxidant Intervention
Schafer, F. Q., Kelley, E. E., & Buettner, G. R. (2002) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812775733_0049 · Cited by 11 · see citing works
Silva, K. M. G., de Moraes, T. A. P., da Silva, E. C. B., et al. (2009) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · doi:10.1590/s0102-09352009000100007 · Cited by 11 · see citing works
El-Shebly, A. A. (2009) · The journal of applied research in veterinary medicine · Cited by 11 · see citing works
Antioxidant Nutrients and Cancer Incidence and Mortality: An Epidemiologic Perspective
Mayne, S. T. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61004-2 · Cited by 11 · see citing works
Nandi, D., Patra, R. C., Ranjan, R., et al. (2008) · University of Zagreb University Computing Centre (SRCE) · Cited by 10 · see citing works
Milech, V., de Oliveira, J. S., de Ataíde, M. W., Coradini, G. P., Mann, T. R., Sarturi, V. Z., Hartmann, H. F., Linhares, M. T., Antunes, B. N., de Andrade, C. M., et al. (2021) · Veterinary Medicine International · doi:10.1155/2021/5515559 · Cited by 9 · see citing works
“Considered one of the main indicators of oxidative damage, GSH plays an important role in protecting cells against changes in an oxidative scenario [47].”
BackgroundAzu, O. (2012) · Journal of AIDS & Clinical Research · doi:10.4172/2155-6113.1000169 · Cited by 13 · see citing works
Kordysh, E. A., Emerit, I., Goldsmith, J. R., et al. (2001) · Archives of Environmental Health An International Journal · doi:10.1080/00039890109604463 · Cited by 7 · see citing works
Interactions Between Nutrients and Growth Factors in Cellular Anabolism and Tissue Repair
Ziegler, T. R., Puckett, A. B., Griffith, D. P., et al. (1997) · Springer eBooks · doi:10.1007/978-1-4612-1876-0_8 · Cited by 6 · see citing works
Tang, Z., Ding, W., WANG, L., et al. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3916 · Cited by 5 · see citing works
“For example, antioxidants, such as VE can scavenge free radicals (8,9) and arrest the lipid peroxidation of lipoproteins that are present within biological membranes (10).”
Durgesh, N. S., ini, & Bhattacharya, L. (2014) · Global Journal of Biology, Agriculture & Health Sciences · Cited by 4 · see citing works
Scherer, F., & Alegre, P. (2008) · Cited by 4 · see citing works
The Effects of Ascorbic Acid and Garlic on Bone Mineralization in Lead Exposed Pregnant Rats
Ebrahimzadeh‐Bideskan, A., Sadeghi, A., Alipour, F., et al. (2015) · Zahedan Journal of Research in Medical Sciences · doi:10.17795/zjrms1280 · Cited by 3 · see citing works
“Therefore, reducing the possibility of lead interacting with critical biomolecules and bolstering the cell’s antioxidant defenses might be associated with the beneficial role of antioxidant nutrients through exogenous supplementation of antioxidant molecules [11, 12].”
El-Shebly, A. A. (2009) · RESEARCH JOURNAL OF FISHERIES AND HYDROBIOLOGY · Cited by 3 · see citing works
Vitamin E and Testicular Damage Protection in Highly Active Antiretroviral Therapy
Azu, O., & Naidu, E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809853-0.00019-5 · Cited by 2 · see citing works
The Effects of Ascorbic Acid and Garlic on Bone Mineralization in Lead Exposed Pregnant Rats
Ebrahimzadeh‐Bideskan, A., Sadeghi, A., Alipour, F., et al. (2015) · Zahedan Journal of Research in Medical Sciences · doi:10.5812/zjrms.1280 · Cited by 1 · see citing works
Patra, R. C., & Swarup, D. (2005) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2005.1130 · Cited by 1 · see citing works
“Tocopherol is a low molecular mass antioxidant that interacts directly with oxidizing radicals, and the status of antioxidant enzymes have been assessed after its supplementation in anoestrus buffaloes (Jones et al., 1995; Kahlon et al., 2003).”
PROGRAMA DE PÓS-GRADUAÇÃO EM GERONTOLOGIA BIOMÉDICA
Morelo, S., & Bosco, D. (2006)
Güvenç, M., Güvenç, A., Yılmaz, Ö., & Tuzcu, M. (2017) · Pakistan Journal of Zoology · doi:10.17582/journal.pjz/2017.49.6.2103.2111
- Authors
- Jones, D.
- Affiliations
- Utah State University (US)
- Corresponding author
- Jones, D
- ORCID
- Jones, D
- Venue
- Fundamental and Applied Toxicology
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 26
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0272-0590 (ISSN-L)
- OpenAlex
- W2065898256
- Cited by
- 60
- References
- 0
- Citations by year
- 2021: 2 · 2018: 2 · 2017: 2 · 2015: 5 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fundamental and Applied Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Keywords
- lipid peroxidation, antioxidant defense, dietary nutrients, oxidative stress, cell damage, human health
- MeSH terms
- Antioxidants, Free Radicals, Glutathione, Humans, Iron, Nutritional Physiological Phenomena, Sulfur, Vitamin E, Lipid Peroxidation
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